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Local climate information is crucial for impact assessment and decision-making, yet coarse global climate simulations cannot capture small-scale phenomena. Current statistical downscaling methods infer these phenomena as temporally…

Machine Learning · Computer Science 2025-09-24 Jonathan Schmidt , Luca Schmidt , Felix Strnad , Nicole Ludwig , Philipp Hennig

Finding frequently occurring subgraph patterns or network motifs in neural architectures is crucial for optimizing efficiency, accelerating design, and uncovering structural insights. However, as the subgraph size increases,…

Machine Learning · Computer Science 2026-02-04 Yikang Yang , Zhengxin Yang , Minghao Luo , Luzhou Peng , Hongxiao Li , Wanling Gao , Lei Wang , Jianfeng Zhan

Recently, diffusion models have achieved great success in image synthesis. However, when it comes to the layout-to-image generation where an image often has a complex scene of multiple objects, how to make strong control over both the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Guangcong Zheng , Xianpan Zhou , Xuewei Li , Zhongang Qi , Ying Shan , Xi Li

Accurate medical image segmentation is essential for effective diagnosis and treatment planning but is often challenged by domain shifts caused by variations in imaging devices, acquisition conditions, and patient-specific attributes.…

Image and Video Processing · Electrical Eng. & Systems 2024-12-06 Jie Bao , Zhixin Zhou , Wen Jung Li , Rui Luo

We introduce FLAG-4D, a novel framework for generating novel views of dynamic scenes by reconstructing how 3D Gaussian primitives evolve through space and time. Existing methods typically rely on a single Multilayer Perceptron (MLP) to…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Guan Yuan Tan , Ngoc Tuan Vu , Arghya Pal , Sailaja Rajanala , Raphael Phan C. -W. , Mettu Srinivas , Chee-Ming Ting

Small-molecule drug discovery requires simultaneous optimization of numerous properties of candidate molecules. These properties can be investigated through the analysis of high-dimensional biological signatures, such as cell morphology and…

Machine Learning · Computer Science 2026-05-28 Łukasz Janisiów , Sebastian Musiał , Bartosz Zieliński , Dawid Rymarczyk , Tomasz Danel

Diffusion models demonstrate remarkable capabilities in capturing complex data distributions and have achieved compelling results in many generative tasks. While they have recently been extended to dense prediction tasks such as depth…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Haorui Ji , Taojun Lin , Hongdong Li

Linearized string representations serve as the foundation of scalable autoregressive molecular generation; however, they introduce a fundamental modality mismatch where a single molecular graph maps to multiple distinct sequences. This…

Machine Learning · Computer Science 2026-03-27 Xinyu Wang , Fei Dou , Jinbo Bi , Minghu Song

Surgical segmentation is pivotal for scene understanding yet remains hindered by annotation scarcity and semantic inconsistency across diverse procedures. Existing approaches typically fine-tune natural foundation models (e.g., SAM) with…

Computer Vision and Pattern Recognition · Computer Science 2025-12-10 Qing Xu , Kun Yuan , Yuxiang Luo , Yuhao Zhai , Wenting Duan , Nassir Navab , Zhen Chen

Predicting how genetic perturbations change cellular state is a core problem for building controllable models of gene regulation. Perturbations targeting the same gene can produce different transcriptional responses depending on their…

Genomics · Quantitative Biology 2026-02-12 Boyang Fu , George Dasoulas , Sameer Gabbita , Xiang Lin , Shanghua Gao , Xiaorui Su , Soumya Ghosh , Marinka Zitnik

Single-cell spatial transcriptomics (ST) offers a unique approach to measuring gene expression profiles and spatial cell locations simultaneously. However, most existing ST methods assume that cells in closer spatial proximity exhibit more…

Genomics · Quantitative Biology 2025-06-10 Xiongtao Xiao , Xiaofeng Chen , Feiyan Jiang , Songming Zhang , Wenming Cao , Cheng Tan , Zhangyang Gao , Zhongshan Li

Generating molecular structures with desired properties is a critical task with broad applications in drug discovery and materials design. We propose 3M-Diffusion, a novel multi-modal molecular graph generation method, to generate diverse,…

Machine Learning · Computer Science 2024-10-04 Huaisheng Zhu , Teng Xiao , Vasant G Honavar

While learned image compression (LIC) focuses on efficient data transmission, generative image compression (GIC) extends this framework by integrating generative modeling to produce photo-realistic reconstructed images. In this paper, we…

Image and Video Processing · Electrical Eng. & Systems 2025-05-28 Minghao Han , Weiyi You , Jinhua Zhang , Leheng Zhang , Ce Zhu , Shuhang Gu

We present a novel generative modeling framework,Wavelet-Fourier-Diffusion, which adapts the diffusion paradigm to hybrid frequency representations in order to synthesize high-quality, high-fidelity images with improved spatial…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Andrew Kiruluta , Andreas Lemos

The rapid development of digital pathology and modern deep learning has facilitated the emergence of pathology foundation models that are expected to solve general pathology problems under various disease conditions in one unified model,…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 Yutong Sun , Sichen Zhu , Peng Qiu

The paradigm shift toward structure-driven molecule generation has been propelled by advances in deep generative models, such as variational auto-encoders and diffusion models. However, these generative models for molecular design remain…

Machine Learning · Computer Science 2026-04-17 Peidong Liu , Wenbo Zhang , Wei Ju , Jiancheng Lv , Xianggen Liu

Diffusion models have recently received increasing research attention for their remarkable transfer abilities in semantic segmentation tasks. However, generating fine-grained segmentation masks with diffusion models often requires…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Koichi Namekata , Amirmojtaba Sabour , Sanja Fidler , Seung Wook Kim

Identifying genes that display spatial patterns is critical to investigating expression interactions within a spatial context and further dissecting biological understanding of complex mechanistic functionality. Despite the increase in…

Methodology · Statistics 2025-10-06 Mingcong Wu , Yang Li , Shuangge Ma , Mengyun Wu

We introduce $\textbf{F}$uture $\textbf{LA}$tent $\textbf{RE}$presentation Alignment ($\textbf{FLARE}$), a novel framework that integrates predictive latent world modeling into robot policy learning. By aligning features from a diffusion…

Diffusion models recently developed for generative AI tasks can produce high-quality samples while still maintaining diversity among samples to promote mode coverage, providing a promising path for learning stochastic closure models.…

Machine Learning · Computer Science 2026-02-20 Xinghao Dong , Huchen Yang , Jin-long Wu