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This study introduces a deep learning framework for the inferential exploration of latent representations in 3D brain MRI, leveraging a simple convolutional autoencoder with a hierarchical encoder and a compact latent space. Trained on…

Applications · Statistics 2026-05-25 J. M. Gorriz , F. Segovia , C. Jimenez , J. E. Arco , F. J. Martinez , J Ramirez , S. Abulikemu , J. Suckling

Latent diffusion models (LDMs) enable high-fidelity synthesis by operating in learned latent spaces. However, training state-of-the-art LDMs requires complex staging: a tokenizer must be trained first, before the diffusion model can be…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Shivam Duggal , Xingjian Bai , Zongze Wu , Richard Zhang , Eli Shechtman , Antonio Torralba , Phillip Isola , William T. Freeman

When dealing with clinical text classification on a small dataset recent studies have confirmed that a well-tuned multilayer perceptron outperforms other generative classifiers, including deep learning ones. To increase the performance of…

Machine Learning · Computer Science 2022-09-27 Thanh-Dung Le , Rita Noumeir , Jerome Rambaud , Guillaume Sans , Philippe Jouvet

In the relentless efforts in enhancing medical diagnostics, the integration of state-of-the-art machine learning methodologies has emerged as a promising research area. In molecular biology, there has been an explosion of data generated…

Machine Learning · Computer Science 2024-05-17 Ibrahim Al-Hurani , Abedalrhman Alkhateeb , Salama Ikki

Autoencoders exhibit impressive abilities to embed the data manifold into a low-dimensional latent space, making them a staple of representation learning methods. However, without explicit supervision, which is often unavailable, the…

Machine Learning · Computer Science 2023-01-12 Felix Leeb , Stefan Bauer , Michel Besserve , Bernhard Schölkopf

Latent diffusion has become the default paradigm for visual generation, yet we observe a persistent reconstruction-generation trade-off as latent dimensionality increases: higher-capacity autoencoders improve reconstruction fidelity but…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Bolin Lai , Xudong Wang , Saketh Rambhatla , James M. Rehg , Zsolt Kira , Rohit Girdhar , Ishan Misra

The robustness of supervised deep learning-based medical image classification is significantly undermined by label noise. Although several methods have been proposed to enhance classification performance in the presence of noisy labels,…

Machine Learning · Computer Science 2024-10-28 Bidur Khanal , Tianhong Dai , Binod Bhattarai , Cristian Linte

The steep computational cost of diffusion models at inference hinders their use as fast physics emulators. In the context of image and video generation, this computational drawback has been addressed by generating in the latent space of an…

Machine Learning · Computer Science 2025-11-04 François Rozet , Ruben Ohana , Michael McCabe , Gilles Louppe , François Lanusse , Shirley Ho

Discriminative classifiers have become a foundational tool in deep learning for medical imaging, excelling at learning separable features of complex data distributions. However, these models often need careful design, augmentation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Gian Mario Favero , Parham Saremi , Emily Kaczmarek , Brennan Nichyporuk , Tal Arbel

Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

Exploiting deep learning in medical imaging faces critical challenges, including strict privacy constraints, heterogeneous imaging devices with varying acquisition properties, and class imbalance due to the uneven prevalence of pathologies.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Martina Pavan , Matteo Caligiuri , Francesco Barbato , Pietro Zanuttigh

We introduce Mediffusion -- a new method for semi-supervised learning with explainable classification based on a joint diffusion model. The medical imaging domain faces unique challenges due to scarce data labelling -- insufficient for…

Computer Vision and Pattern Recognition · Computer Science 2024-11-15 Joanna Kaleta , Paweł Skierś , Jan Dubiński , Przemysław Korzeniowski , Kamil Deja

Many real-world classification problems have imbalanced frequency of class labels; a well-known issue known as the "class imbalance" problem. Classic classification algorithms tend to be biased towards the majority class, leaving the…

Multi-modal foundation models are typically trained on millions of pairs of natural images and text captions, frequently obtained through web-crawling approaches. Although such models depict excellent generative capabilities, they do not…

Computer Vision and Pattern Recognition · Computer Science 2023-01-03 Pierre Chambon , Christian Bluethgen , Curtis P. Langlotz , Akshay Chaudhari

Medical image classification is one of the most critical problems in the image recognition area. One of the major challenges in this field is the scarcity of labelled training data. Additionally, there is often class imbalance in datasets…

Image and Video Processing · Electrical Eng. & Systems 2022-09-29 Khushboo Mehra , Hassan Soliman , Soumya Ranjan Sahoo

While diffusion Multimodal Large Language Models (dMLLMs) have recently achieved remarkable strides in multimodal generation, the development of interpretability mechanisms has lagged behind their architectural evolution. Unlike traditional…

Artificial Intelligence · Computer Science 2026-04-14 Haomin Zuo , Yidi Li , Luoxiao Yang , Xiaofeng Zhang

Data limitation is one of the most common issues in training machine learning classifiers for medical applications. Due to ethical concerns and data privacy, the number of people that can be recruited to such experiments is generally…

Audio and Speech Processing · Electrical Eng. & Systems 2020-04-14 Bahman Mirheidari , Yilin Pan , Daniel Blackburn , Ronan O'Malley , Traci Walker , Annalena Venneri , Markus Reuber , Heidi Christensen

Generative models have been very popular in the recent years for their image generation capabilities. GAN-based models are highly regarded for their disentangled latent space, which is a key feature contributing to their success in…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Yusuf Dalva , Pinar Yanardag

Image generative models, particularly diffusion-based models, have surged in popularity due to their remarkable ability to synthesize highly realistic images. However, since these models are data-driven, they inherit biases from the…

Machine Learning · Computer Science 2025-03-18 Lin-Chun Huang , Ching Chieh Tsao , Fang-Yi Su , Jung-Hsien Chiang

Medical image data are usually imbalanced across different classes. One-class classification has attracted increasing attention to address the data imbalance problem by distinguishing the samples of the minority class from the majority…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Long Gao , Chang Liu , Dooman Arefan , Ashok Panigrahy , Shandong Wu