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Diffusion models are a new class of generative models, and have dramatically promoted image generation with unprecedented quality and diversity. Existing diffusion models mainly try to reconstruct input image from a corrupted one with a…

Computer Vision and Pattern Recognition · Computer Science 2024-06-05 Ling Yang , Jingwei Liu , Shenda Hong , Zhilong Zhang , Zhilin Huang , Zheming Cai , Wentao Zhang , Bin Cui

The rapid advancement of single-cell ATAC sequencing (scATAC-seq) technologies holds great promise for investigating the heterogeneity of epigenetic landscapes at the cellular level. The amplification process in scATAC-seq experiments often…

Genomics · Quantitative Biology 2024-08-28 Lei Huang , Lei Xiong , Na Sun , Zunpeng Liu , Ka-Chun Wong , Manolis Kellis

This paper reports on the development of \textbf{a novel style guided diffusion model (SGDiff)} which overcomes certain weaknesses inherent in existing models for image synthesis. The proposed SGDiff combines image modality with a…

Computer Vision and Pattern Recognition · Computer Science 2023-08-16 Zhengwentai Sun , Yanghong Zhou , Honghong He , P. Y. Mok

Denoising Diffusion Probabilistic Models have shown extraordinary ability on various generative tasks. However, their slow inference speed renders them impractical in speech synthesis. This paper proposes a linear diffusion model (LinDiff)…

Sound · Computer Science 2023-06-13 Haogeng Liu , Tao Wang , Jie Cao , Ran He , Jianhua Tao

Diffusion models have gained prominence in generating high-quality sequences of text. Nevertheless, current approaches predominantly represent discrete text within a continuous diffusion space, which incurs substantial computational…

Machine Learning · Computer Science 2023-10-17 Shansan Gong , Mukai Li , Jiangtao Feng , Zhiyong Wu , Lingpeng Kong

The recent advancement of spatial transcriptomics (ST) allows to characterize spatial gene expression within tissue for discovery research. However, current ST platforms suffer from low resolution, hindering in-depth understanding of…

Image and Video Processing · Electrical Eng. & Systems 2025-11-05 Xiaofei Wang , Xingxu Huang , Stephen J. Price , Chao Li

The challenge in controlling stochastic systems in which low-probability events can set the system on catastrophic trajectories is to develop a robust ability to respond to such events without significantly compromising the optimality of…

Populations and Evolution · Quantitative Biology 2020-10-28 Dalit Engelhardt

Histo-genomic multimodal survival prediction has garnered growing attention for its remarkable model performance and potential contributions to precision medicine. However, a significant challenge in clinical practice arises when only…

Machine Learning · Computer Science 2025-03-17 Fengchun Liu , Linghan Cai , Zhikang Wang , Zhiyuan Fan , Jin-gang Yu , Hao Chen , Yongbing Zhang

We introduce MxDiffusion, a hybrid physics- and data-driven diffusion-based framework that enables efficient and highly accurate generation of photonic structures from target optical properties. The improved accuracy is achieved through a…

Optics · Physics 2026-02-20 Sujoy Mondal , Taehyuk Park , Sudipta Biswas , Alan X. Wang , Wenshan Cai

Understanding the neural basis of behavior is a fundamental goal in neuroscience. Current research in large-scale neuro-behavioral data analysis often relies on decoding models, which quantify behavioral information in neural data but lack…

Neurons and Cognition · Quantitative Biology 2024-11-27 Yule Wang , Chengrui Li , Weihan Li , Anqi Wu

Diffusion models achieve remarkable success in processing images and text, and have been extended to special domains such as time series forecasting (TSF). Existing diffusion-based approaches for TSF primarily focus on modeling…

Computation and Language · Computer Science 2025-04-29 Chen Su , Yuanhe Tian , Yan Song

While multimodal survival prediction models are increasingly more accurate, their complexity often reduces interpretability, limiting insight into how different data sources influence predictions. To address this, we introduce DIMAFx, an…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Aniek Eijpe , Soufyan Lakbir , Melis Erdal Cesur , Sara P. Oliveira , Angelos Chatzimparmpas , Sanne Abeln , Wilson Silva

Diffusion models have recently emerged as powerful tools for missing data imputation by modeling the joint distribution of observed and unobserved variables. However, existing methods, typically based on stochastic denoising diffusion…

Artificial Intelligence · Computer Science 2025-08-06 Youran Zhou , Mohamed Reda Bouadjenek , Sunil Aryal

Generative models have the potential to accelerate key steps in the discovery of novel molecular therapeutics and materials. Diffusion models have recently emerged as a powerful approach, excelling at unconditional sample generation and,…

Biomolecules · Quantitative Biology 2024-07-17 Leo Klarner , Tim G. J. Rudner , Garrett M. Morris , Charlotte M. Deane , Yee Whye Teh

Single image super-resolution (SISR) aims to reconstruct high-resolution (HR) images from the given low-resolution (LR) ones, which is an ill-posed problem because one LR image corresponds to multiple HR images. Recently, learning-based…

Computer Vision and Pattern Recognition · Computer Science 2021-05-19 Haoying Li , Yifan Yang , Meng Chang , Huajun Feng , Zhihai Xu , Qi Li , Yueting Chen

We study the problem of domain adaptation under distribution shift, where the shift is due to a change in the distribution of an unobserved, latent variable that confounds both the covariates and the labels. In this setting, neither the…

Recent advances in vision-language pre-training have enabled machines to perform better in multimodal object discrimination (e.g., image-text semantic alignment) and image synthesis (e.g., text-to-image generation). On the other hand,…

Computer Vision and Pattern Recognition · Computer Science 2023-06-02 Xiao Dong , Runhui Huang , Xiaoyong Wei , Zequn Jie , Jianxing Yu , Jian Yin , Xiaodan Liang

Generative diffusion priors have recently achieved state-of-the-art performance in natural image super-resolution, demonstrating a powerful capability to synthesize photorealistic details. However, their direct application to remote sensing…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Enzhuo Zhang , Sijie Zhao , Dilxat Muhtar , Zhenshi Li , Xueliang Zhang , Pengfeng Xiao

The accurate prediction of drug responses remains a formidable challenge, particularly at the single-cell level and in clinical treatment contexts. Some studies employ transfer learning techniques to predict drug responses in individual…

Machine Learning · Computer Science 2025-06-03 Ran Song , Yinpu Bai , Hui Liu

Effective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models…

Machine Learning · Computer Science 2025-03-04 Guanlue Li , Chenran Jiang , Ziqi Gao , Yu Liu , Chenyang Liu , Jiean Chen , Yong Huang , Jia Li