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Diffusion Probabilistic Models (DPMs) have demonstrated significant potential in 3D medical image segmentation tasks. However, their high computational cost and inability to fully capture global 3D contextual information limit their…

Image and Video Processing · Electrical Eng. & Systems 2025-04-17 Kangbo Ma

Classical methods in robot motion planning, such as sampling-based and optimization-based methods, often struggle with scalability towards higher-dimensional state spaces and complex environments. Diffusion models, known for their…

Robotics · Computer Science 2026-03-20 Edward Sandra , Lander Vanroye , Dries Dirckx , Ruben Cartuyvels , Jan Swevers , Wilm Decré

Multiplex imaging is revolutionizing pathology by enabling the simultaneous visualization of multiple biomarkers within tissue samples, providing molecular-level insights that traditional hematoxylin and eosin (H&E) staining cannot provide.…

Image and Video Processing · Electrical Eng. & Systems 2026-01-06 Hyun-Jic Oh , Junsik Kim , Zhiyi Shi , Yichen Wu , Yu-An Chen , Peter K Sorger , Hanspeter Pfister , Won-Ki Jeong

Diffusion models are widely used in image generation because they can generate high-quality and realistic samples. This is in contrast to generative adversarial networks (GANs) and variational autoencoders (VAEs), which have some…

Computer Vision and Pattern Recognition · Computer Science 2025-08-21 Xudong Ling , Chaorong Li , Fengqing Qin , Peng Yang , Yuanyuan Huang

Conditional diffusion models have made impressive progress in the field of image processing, but the characteristics of constructing data distribution pathways make it difficult to exploit the intrinsic correlation between tasks in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Chengjie Huang , Jiafeng Yan , Jing Li , Lu Bai

Diffusion models have led to the revolutionizing of generative modeling in numerous image synthesis tasks. Nevertheless, it is not trivial to directly apply diffusion models for synthesizing an image of a target person wearing a given…

Computer Vision and Pattern Recognition · Computer Science 2024-09-13 Siqi Wan , Yehao Li , Jingwen Chen , Yingwei Pan , Ting Yao , Yang Cao , Tao Mei

Gene regulation is a dynamic process that connects genotype and phenotype. Given the difficulty of physically mapping mammalian gene circuitry, we require new computational methods to learn regulatory rules. Natural language is a valuable…

Quantitative Methods · Quantitative Biology 2022-10-27 William Connell , Umair Khan , Michael J. Keiser

Offline reinforcement learning (RL) aims to learn policies from pre-existing datasets without further interactions, making it a challenging task. Q-learning algorithms struggle with extrapolation errors in offline settings, while supervised…

Artificial Intelligence · Computer Science 2025-01-03 Zhengbang Zhu , Minghuan Liu , Liyuan Mao , Bingyi Kang , Minkai Xu , Yong Yu , Stefano Ermon , Weinan Zhang

Virtual cell modeling aims to predict cellular responses to diverse perturbations but faces challenges from biological complexity, multimodal data heterogeneity, and the need for interdisciplinary expertise. We introduce CellForge, a…

The effectiveness of super resolution (SR) models hinges on their ability to recover high frequency structure without introducing artifacts. Diffusion based approaches have recently advanced the state of the art in SR. However, most…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Maryam Heidari , Nantheera Anantrasirichai , Alin Achim

Diffusion models have emerged as powerful generative models for graph generation, yet their use for conditional graph generation remains a fundamental challenge. In particular, guiding diffusion models on graphs under arbitrary reward…

Machine Learning · Computer Science 2025-05-27 Victor M. Tenorio , Nicolas Zilberstein , Santiago Segarra , Antonio G. Marques

Single-cell RNA sequencing (scRNA-seq) data are important for studying the laws of life at single-cell level. However, it is still challenging to obtain enough high-quality scRNA-seq data. To mitigate the limited availability of data,…

Quantitative Methods · Quantitative Biology 2024-03-06 Erpai Luo , Minsheng Hao , Lei Wei , Xuegong Zhang

We introduce MultiDiff, a novel approach for consistent novel view synthesis of scenes from a single RGB image. The task of synthesizing novel views from a single reference image is highly ill-posed by nature, as there exist multiple,…

Computer Vision and Pattern Recognition · Computer Science 2024-06-27 Norman Müller , Katja Schwarz , Barbara Roessle , Lorenzo Porzi , Samuel Rota Bulò , Matthias Nießner , Peter Kontschieder

Deep MRI reconstruction is commonly performed with conditional models that de-alias undersampled acquisitions to recover images consistent with fully-sampled data. Since conditional models are trained with knowledge of the imaging operator,…

Image and Video Processing · Electrical Eng. & Systems 2023-09-19 Alper Güngör , Salman UH Dar , Şaban Öztürk , Yilmaz Korkmaz , Gokberk Elmas , Muzaffer Özbey , Tolga Çukur

Creating novel images by fusing visual cues from multiple sources is a fundamental yet underexplored problem in image-to-image generation, with broad applications in artistic creation, virtual reality and visual media. Existing methods…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Zeren Xiong , Yue Yu , Zedong Zhang , Shuo Chen , Jian Yang , Jun Li

Identifying subtle phenotypic variations in cellular images is critical for advancing biological research and accelerating drug discovery. These variations are often masked by the inherent cellular heterogeneity, making it challenging to…

Computer Vision and Pattern Recognition · Computer Science 2026-01-28 Anis Bourou , Biel Castaño Segade , Thomas Boyer , Valérie Mezger , Auguste Genovesio

Masked diffusion models (MDMs) have achieved notable progress in modeling discrete data, while their potential in molecular generation remains underexplored. In this work, we explore their potential and introduce the surprising result that…

Machine Learning · Computer Science 2025-09-29 Hyunjin Seo , Taewon Kim , Sihyun Yu , SungSoo Ahn

Recent progress has shown that video diffusion models (VDMs) can be repurposed for diverse multimodal graphics tasks. However, existing methods often train separate models for each problem setting, which fixes the input-output mapping and…

Computer Vision and Pattern Recognition · Computer Science 2026-05-04 Houyuan Chen , Hong Li , Xianghao Kong , Tianrui Zhu , Shaocong Xu , Weiqing Xiao , Yuwei Guo , Chongjie Ye , Lvmin Zhang , Hao Zhao , Anyi Rao

Single-cell RNA sequencing (scRNA-seq), especially temporally resolved datasets, enables genome-wide profiling of gene expression dynamics at single-cell resolution across discrete time points. However, current technologies provide only…

Genomics · Quantitative Biology 2025-11-19 Yue Ling , Peiqi Zhang , Zhenyi Zhang , Peijie Zhou

Cell-based, mathematical modeling of collective cell behavior has become a prominent tool in developmental biology. Cell-based models represent individual cells as single particles or as sets of interconnected particles, and predict the…

Cell Behavior · Quantitative Biology 2019-03-12 Henri B. Wolff , Lance A. Davidson , Roeland M. H. Merks