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Clinical trials are critical for advancing medical treatments but remain prohibitively expensive and time-consuming. Accurate prediction of clinical trial outcomes can significantly reduce research and development costs and accelerate drug…

Machine Learning · Computer Science 2025-06-06 Fengze Liu , Haoyu Wang , Joonhyuk Cho , Dan Roth , Andrew W. Lo

Large language models (LLMs) remain unreliable for high-stakes claim verification due to hallucinations and shallow reasoning. While retrieval-augmented generation (RAG) and multi-agent debate (MAD) address this, they are limited by…

Computation and Language · Computer Science 2026-05-13 Masnun Nuha Chowdhury , Nusrat Jahan Beg , Umme Hunny Khan , Syed Rifat Raiyan , Md Kamrul Hasan , Hasan Mahmud

Large Language Model (LLM)-based recommendation systems have demonstrated remarkable capabilities in understanding user preferences and generating personalized suggestions. However, existing approaches face critical challenges in…

Information Retrieval · Computer Science 2026-04-24 Sushant Mehta

Evaluating large language models (LLMs) has recently emerged as a critical issue for safe and trustworthy application of LLMs in the medical domain. Although a variety of static medical question-answering (QA) benchmarks have been proposed,…

Computation and Language · Computer Science 2025-12-12 Gyutaek Oh , Sangjoon Park , Byung-Hoon Kim

The adoption of large language models (LLMs) in healthcare has attracted significant research interest. However, their performance in healthcare remains under-investigated and potentially limited, due to i) they lack rich domain-specific…

Artificial Intelligence · Computer Science 2024-05-21 Zishan Gu , Fenglin Liu , Changchang Yin , Ping Zhang

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

While state-of-the-art language models (LMs) surpass the vast majority of humans in certain domains, their reasoning remains largely opaque, undermining trust in their output. Furthermore, while autoregressive LMs can output explicit…

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

Computation and Language · Computer Science 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Misdiagnosis causes significant harm to healthcare systems worldwide, leading to increased costs and patient risks. MedRAG is a smart multimodal healthcare copilot equipped with powerful large language model (LLM) reasoning, designed to…

Artificial Intelligence · Computer Science 2025-06-04 Xuejiao Zhao , Siyan Liu , Su-Yin Yang , Chunyan Miao

Recent advances in autonomous digital agents from industry (e.g., Manus AI and Gemini's research mode) highlight potential for structured tasks by autonomous decision-making and task decomposition; however, it remains unclear to what extent…

Artificial Intelligence · Computer Science 2025-09-03 Yen-Che Chien , Kuang-Da Wang , Wei-Yao Wang , Wen-Chih Peng

The rapid spread of memes makes harmful content detection increasingly crucial, as effective identification can curb the circulation of misinformation. However, existing methods rely heavily on high-volume annotated data, which leads to…

Machine Learning · Computer Science 2026-05-06 Zihan Ding , Ziyuan Yang , Yi Zhang

Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields. While Retrieval-Augmented Generation…

Computation and Language · Computer Science 2026-03-25 Wenhao Wu , Zhentao Tang , Yafu Li , Shixiong Kai , Mingxuan Yuan , Chunlin Chen , Zhi Wang

Advanced Persistent Threats (APTs) pose critical challenges to modern cybersecurity due to their multi-stage and stealthy nature. While provenance-based detection approaches show promise in capturing causal attack semantics, current threat…

Cryptography and Security · Computer Science 2026-03-11 Wenhao Yan , Ning An , Linxu Li , Bingsheng Bi , Bo Jiang , Zhigang Lu , Baoxu Liu , Junrong Liu , Cong Dong

Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Multimodal Retrieval-Augmented Generation (MRAG) enhances large language models (LLMs) by integrating multimodal data (text, images, videos) into retrieval and generation processes, overcoming the limitations of text-only…

Information Retrieval · Computer Science 2025-04-15 Lang Mei , Siyu Mo , Zhihan Yang , Chong Chen

Multimodal Retrieval-Augmented Generation (MRAG) systems enhance LMMs by integrating external multimodal databases, but introduce unexplored privacy vulnerabilities. While text-based RAG privacy risks have been studied, multimodal data…

Cryptography and Security · Computer Science 2025-05-21 Jiankun Zhang , Shenglai Zeng , Jie Ren , Tianqi Zheng , Hui Liu , Xianfeng Tang , Hui Liu , Yi Chang

Retrieval-Augmented Generation (RAG) enables large language models (LLMs) to access external knowledge sources, but the effectiveness of RAG relies on the coordination between the retriever and the generator. Since these components are…

Computation and Language · Computer Science 2025-09-24 Junlin Wang , Zehao Wu , Shaowei Lu , Yanlan Li , Xinghao Huang

Large-scale single-cell and Perturb-seq investigations routinely involve clustering cells and subsequently annotating each cluster with Gene-Ontology (GO) terms to elucidate the underlying biological programs. However, both stages,…

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi