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Popular technologies for generating spatially resolved transcriptomic data measure gene expression at the resolution of a "spot", i.e., a small tissue region 55 microns in diameter. Each spot can contain many cells of different types. In…
The pre-ranking stage plays a pivotal role in large-scale recommender systems but faces an intrinsic trade-off between model expressiveness and computational efficiency. Owing to the massive candidate pool and strict latency constraints,…
Real-world object detection systems, such as those in autonomous driving and surveillance, must continuously learn new object categories and simultaneously adapt to changing environmental conditions. Existing approaches, Class Incremental…
In this work, we introduce DUET (Dual-model Efficient Two-stage inference), a collaborative inference framework in which a capable model and a lightweight model work together to solve a task. Relying on a single large model to perform…
Multiview Self-Supervised Learning (MSSL) is based on learning invariances with respect to a set of input transformations. However, invariance partially or totally removes transformation-related information from the representations, which…
Zero-shot learning (ZSL) aims to predict unseen classes whose samples have never appeared during training. One of the most effective and widely used semantic information for zero-shot image classification are attributes which are…
Spatial transcriptomics (ST) is an emerging technology that enables researchers to investigate the molecular relationships underlying tissue morphology. However, acquiring ST data remains prohibitively expensive, and traditional fixed-grid…
Domain-Incremental Learning (DIL) involves the progressive adaptation of a model to new concepts across different domains. While recent advances in pre-trained models provide a solid foundation for DIL, learning new concepts often results…
Spatial Transcriptomics (ST) merges the benefits of pathology images and gene expression, linking molecular profiles with tissue structure to analyze spot-level function comprehensively. Predicting gene expression from histology images is a…
Spatial transcriptomics (ST) maps gene expression within tissue at individual spots, making it a valuable resource for multimodal representation learning. Additionally, ST inherently contains rich hierarchical information both across and…
Spatial transcriptomics (ST) provides essential spatial context by mapping gene expression within tissue, enabling detailed study of cellular heterogeneity and tissue organization. However, aligning ST data with histology images poses…
Pathology foundation models learn morphological representations through self-supervised pretraining on large-scale whole-slide images, yet they do not explicitly capture the underlying molecular state of the tissue. Spatial transcriptomics…
Spatial transcriptomics (ST) provides crucial insights into tissue micro-environments, but is limited to its high cost and complexity. As an alternative, predicting gene expression from pathology whole slide images (WSI) is gaining…
The development of single-cell and spatial transcriptomics has revolutionized our capacity to investigate cellular properties, functions, and interactions in both cellular and spatial contexts. However, the analysis of single-cell and…
Spatial Transcriptomics (ST) is a technology that measures gene expression profiles within tissue sections while retaining spatial context. It reveals localized gene expression patterns and tissue heterogeneity, both of which are essential…
The performance of an LLM depends heavily on the relevance of its training data to the downstream evaluation task. However, in practice, the data involved in an unseen evaluation task is often unknown (e.g., conversations between an LLM and…
Single-cell spatial transcriptomics (ST) offers a unique approach to measuring gene expression profiles and spatial cell locations simultaneously. However, most existing ST methods assume that cells in closer spatial proximity exhibit more…
Prompt tuning methods have achieved remarkable success in parameter-efficient fine-tuning on large pre-trained models. However, their application to dual-modal fusion-based visual-language pre-trained models (VLPMs), such as GLIP, has…
Spatial transcriptomics (ST) reveals spatial heterogeneity of gene expression, yet its resolution is limited by current platforms. Recent methods enhance resolution via H&E-stained histology, but three major challenges persist: (1)…
Spatial transcriptomics (ST) provides spatially resolved measurements of gene expression, enabling characterization of the molecular landscape of human tissue beyond histological assessment as well as localized readouts that can be aligned…