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Accessing longitudinal multimodal Electronic Healthcare Records (EHRs) is challenging due to privacy concerns, which hinders the use of ML for healthcare applications. Synthetic EHRs generation bypasses the need to share sensitive real…

Computation and Language · Computer Science 2022-11-04 Zifeng Wang , Jimeng Sun

Hidden Markov Models (HMMs) are foundational tools for modeling sequential data with latent Markovian structure, yet fitting them to real-world data remains computationally challenging. In this work, we show that pre-trained large language…

Machine Learning · Computer Science 2026-04-27 Yijia Dai , Zhaolin Gao , Yahya Sattar , Sarah Dean , Jennifer J. Sun

In hospitals, data are siloed to specific information systems that make the same information available under different modalities such as the different medical imaging exams the patient undergoes (CT scans, MRI, PET, Ultrasound, etc.) and…

Computer Vision and Pattern Recognition · Computer Science 2021-02-03 Tristan Sylvain , Francis Dutil , Tess Berthier , Lisa Di Jorio , Margaux Luck , Devon Hjelm , Yoshua Bengio

The recent rapid advancements in language models (LMs) have garnered attention in medical time series-text multimodal learning. However, existing contrastive learning-based and prompt-based LM approaches tend to be biased, often assigning a…

Machine Learning · Computer Science 2025-09-09 Jiexia Ye , Weiqi Zhang , Ziyue Li , Jia Li , Meng Zhao , Fugee Tsung

Rapid advancements in imaging techniques and analytical methods over the past decade have revolutionized our ability to comprehensively probe the biological world at multiple scales, pinpointing the type, quantity, location, and even…

Artificial Intelligence · Computer Science 2025-10-02 Shanghang Zhang , Gaole Dai , Tiejun Huang , Jianxu Chen

This research examines the use of Large Language Models (LLMs) in predicting time series, with a specific focus on the LLMTIME model. Despite the established effectiveness of LLMs in tasks such as text generation, language translation, and…

Machine Learning · Computer Science 2024-08-12 Rui Cao , Qiao Wang

Analysis of longitudinal Electronic Health Record (EHR) data is an important goal for precision medicine. Difficulty in applying Machine Learning (ML) methods, either predictive or unsupervised, stems in part from the heterogeneity and…

Quantitative Methods · Quantitative Biology 2022-04-18 Alan D. Kaplan , Uttara Tipnis , Jean C. Beckham , Nathan A. Kimbrel , David W. Oslin , Benjamin H. McMahon

Large language models (LLMs) have shown remarkable in-context learning (ICL) capabilities, yet their potential for sequential decision-making remains underexplored. In this paper, we study the ICL capabilities of LLMs in sequential…

Machine Learning · Computer Science 2026-05-12 Minmin Zhang , Sina Aghaei , Soroush Saghafian

Self-supervised learning (SSL) for clinical time series data has received significant attention in recent literature, since these data are highly rich and provide important information about a patient's physiological state. However, most…

Machine Learning · Computer Science 2023-07-21 Aniruddh Raghu , Payal Chandak , Ridwan Alam , John Guttag , Collin M. Stultz

Multi-turn dialogues and context-intensive tasks challenge Large Language Models (LLMs) to integrate long histories without sacrificing generation quality. Although prefix LLMs can better exploit historical context via bidirectional…

Computation and Language · Computer Science 2026-02-18 HaoYuan Hu , Mingcong Lu , Di Luo , XinYa Wu , Jiangcai Zhu , Taoye Yin , Zheng Li , Hao Wang , Shusheng Zhang , KeZun Zhang , KaiLai Shao , Chao Chen , Feng Wang

Simultaneous speech translation (SST) outputs translations in parallel with streaming speech input, balancing translation quality and latency. While large language models (LLMs) have been extended to handle the speech modality, streaming…

Computation and Language · Computer Science 2025-04-23 Keqi Deng , Wenxi Chen , Xie Chen , Philip C. Woodland

Large language models (LLMs) show promise for improving the efficiency of qualitative analysis in large, multi-site health-services research. Yet methodological guidance for LLM integration into qualitative analysis and evidence of their…

Computation and Language · Computer Science 2026-01-22 Sasha Ronaghi , Emma-Louise Aveling , Maria Levis , Rachel Lauren Ross , Emily Alsentzer , Sara Singer

Accurate beam prediction is a key enabler for next-generation wireless communication systems. In this paper, we propose a multimodal large language model (LLM)-based beam prediction framework that effectively utilizes contextual…

Signal Processing · Electrical Eng. & Systems 2026-03-24 Tianhao Mao , Le Liang , Jie Yang , Xiao Li , Shi Jin , Geoffrey Ye Li

Unstructured data in Electronic Health Records (EHRs) often contains critical information -- complementary to imaging -- that could inform radiologists' diagnoses. But the large volume of notes often associated with patients together with…

Computation and Language · Computer Science 2024-06-12 Hiba Ahsan , Denis Jered McInerney , Jisoo Kim , Christopher Potter , Geoffrey Young , Silvio Amir , Byron C. Wallace

Analysis of multivariate healthcare time series data is inherently challenging: irregular sampling, noisy and missing values, and heterogeneous patient groups with different dynamics violating exchangeability. In addition, interpretability…

Machine Learning · Computer Science 2023-11-15 Onur Poyraz , Pekka Marttinen

Increased use of sensor signals from wearable devices as rich sources of physiological data has sparked growing interest in developing health monitoring systems to identify changes in an individual's health profile. Indeed, machine learning…

Machine Learning · Computer Science 2022-10-17 Magda Amiridi , Gregory Darnell , Sean Jewell

We propose a fully data-driven approach to designing mutual information (MI) estimators. Since any MI estimator is a function of the observed sample from two random variables, we parameterize this function with a neural network (MIST) and…

Machine Learning · Computer Science 2026-02-24 German Gritsai , Megan Richards , Maxime Méloux , Kyunghyun Cho , Maxime Peyrard

Large Language Model (LLM)-based systems present new opportunities for autonomous health monitoring in sensor-rich industrial environments. This study explores the potential of LLMs to detect and classify faults directly from sensor data,…

Artificial Intelligence · Computer Science 2025-09-30 Xian Yeow Lee , Lasitha Vidyaratne , Ahmed Farahat , Chetan Gupta

In a research context, image acquisition will often involve a pre-defined static protocol and the data will be of high quality. If we are to build applications that work in hospitals without significant operational changes in care delivery,…

Computer Vision and Pattern Recognition · Computer Science 2018-07-18 Thomas Varsavsky , Zach Eaton-Rosen , Carole H. Sudre , Parashkev Nachev , M. Jorge Cardoso

While Large Language Models (LLMs) have exhibited remarkable emergent capabilities through extensive pre-training, they still face critical limitations in generalizing to specialized domains and handling diverse linguistic variations, known…

Computation and Language · Computer Science 2025-05-28 Jinwu Hu , Zhitian Zhang , Guohao Chen , Xutao Wen , Chao Shuai , Wei Luo , Bin Xiao , Yuanqing Li , Mingkui Tan