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Contemporary large language models (LLMs) may have utility for processing unstructured, narrative free-text clinical data contained in electronic health records (EHRs) -- a particularly important use-case for mental health where a majority…

Artificial Intelligence · Computer Science 2024-04-01 Niall Taylor , Andrey Kormilitzin , Isabelle Lorge , Alejo Nevado-Holgado , Dan W Joyce

Timeseries regression models often struggle to leverage large volumes of labeled multimodal data, particularly when the data are irregularly sampled or contain missing values. This is common in domains like healthcare and predictive…

Machine Learning · Computer Science 2026-05-18 Antoine Honoré , Ming Xiao

Background and Objectives: Multidrug Resistance (MDR) is a critical global health issue, causing increased hospital stays, healthcare costs, and mortality. This study proposes an interpretable Machine Learning (ML) framework for MDR…

Multimodal time series forecasting has garnered significant attention for its potential to provide more accurate predictions than traditional single-modality models by leveraging rich information inherent in other modalities. However, due…

Machine Learning · Computer Science 2026-02-26 Jiafeng Lin , Yuxuan Wang , Huakun Luo , Zhongyi Pei , Jianmin Wang

Recent advances in large language models (LLMs) have shown potential in clinical text summarization, but their ability to handle long patient trajectories with multi-modal data spread across time remains underexplored. This study…

Computation and Language · Computer Science 2025-09-08 Maya Kruse , Shiyue Hu , Nicholas Derby , Yifu Wu , Samantha Stonbraker , Bingsheng Yao , Dakuo Wang , Elizabeth Goldberg , Yanjun Gao

A two-stage adaptive optimal design is an attractive option for increasing the efficiency of clinical trials. In these designs, based on interim data, the locally optimal dose is chosen for further exploration, which induces dependencies…

Methodology · Statistics 2019-05-24 Zhantao Lin , Nancy Flournoy , William F. Rosenberger

The scientific reasoning ability of large language models (LLMs) has recently attracted significant attention. Time series, as a fundamental modality in scientific data, presents unique challenges that are often overlooked in current…

Forecasting the short-term spread of an ongoing disease outbreak is a formidable challenge due to the complexity of contributing factors, some of which can be characterized through interlinked, multi-modality variables such as…

Machine Learning · Computer Science 2024-04-11 Hongru Du , Jianan Zhao , Yang Zhao , Shaochong Xu , Xihong Lin , Yiran Chen , Lauren M. Gardner , Hao Frank Yang

Radiology report generation (RRG) models typically focus on individual exams, often overlooking the integration of historical visual or textual data, which is crucial for patient follow-ups. Traditional methods usually struggle with long…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Tengfei Liu , Jiapu Wang , Yongli Hu , Mingjie Li , Junfei Yi , Xiaojun Chang , Junbin Gao , Baocai Yin

Irregularly sampled multivariate time series (ISMTS) are prevalent in reality. Most existing methods treat ISMTS as synchronized regularly sampled time series with missing values, neglecting that the irregularities are primarily attributed…

Machine Learning · Computer Science 2024-12-03 Jiexi Liu , Meng Cao , Songcan Chen

In an era defined by the explosive growth of data and rapid technological advancements, Multimodal Large Language Models (MLLMs) stand at the forefront of artificial intelligence (AI) systems. Designed to seamlessly integrate diverse data…

Reasoning-augmented machine learning systems have shown improved performance in various domains, including image generation. However, existing reasoning-based methods for image generation either restrict reasoning to a single modality…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Yapeng Mi , Yanpeng Zhao , Hengli Li , Chenxi Li , Huimin Wu , Xiaojian Ma , Song-Chun Zhu , Ying Nian Wu , Qing Li

A crucial component for clinical risk prediction is developing a reliable prediction model is collecting high-quality time series clinical events. In this work, we release such a dataset that consists of 22,588,586 Clinical Time Series…

Artificial Intelligence · Computer Science 2025-11-19 Jing Wang , Xing Niu , Tong Zhang , Jie Shen , Juyong Kim , Jeremy C. Weiss

Predicting patient features from single-cell data can help identify cellular states implicated in health and disease. Linear models and average cell type expressions are typically favored for this task for their efficiency and robustness,…

Machine Learning · Computer Science 2024-03-11 Jan P. Engelmann , Alessandro Palma , Jakub M. Tomczak , Fabian J. Theis , Francesco Paolo Casale

Time series anomaly detection is critical for supply chain management to take proactive operations, but faces challenges: classical unsupervised anomaly detection based on exploiting data patterns often yields results misaligned with…

Machine Learning · Computer Science 2026-01-28 Haoting Zhang , Shekhar Jain

Large Language Models (LLMs) have achieved remarkable success in various fields, prompting several studies to explore their potential in recommendation systems. However, these attempts have so far resulted in only modest improvements over…

Information Retrieval · Computer Science 2024-09-20 Junyi Chen , Lu Chi , Bingyue Peng , Zehuan Yuan

Electronic health records (EHR) is an inherently multimodal register of the patient's health status characterized by static data and multivariate time series (MTS). While MTS are a valuable tool for clinical prediction, their fusion with…

Rich Electronic Health Records (EHR), have created opportunities to improve clinical processes using machine learning methods. Prediction of the same patient events at different time horizons can have very different applications and…

Machine Learning · Computer Science 2023-03-07 Hao Liu , Muhan Zhang , Zehao Dong , Lecheng Kong , Yixin Chen , Bradley Fritz , Dacheng Tao , Christopher King

Humans possess the capability to comprehend diverse modalities and seamlessly transfer information between them. In this work, we introduce ModaVerse, a Multi-modal Large Language Model (MLLM) capable of comprehending and transforming…

Computer Vision and Pattern Recognition · Computer Science 2024-04-05 Xinyu Wang , Bohan Zhuang , Qi Wu

Motivated by the substantial achievements observed in Large Language Models (LLMs) in the field of natural language processing, recent research has commenced investigations into the application of LLMs for complex, long-horizon sequential…

Robotics · Computer Science 2023-08-29 Zhehua Zhou , Jiayang Song , Kunpeng Yao , Zhan Shu , Lei Ma
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