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Introspection of deep supervised predictive models trained on functional and structural brain imaging may uncover novel markers of Alzheimer's disease (AD). However, supervised training is prone to learning from spurious features (shortcut…

Machine Learning · Computer Science 2022-05-24 Alex Fedorov , Lei Wu , Tristan Sylvain , Margaux Luck , Thomas P. DeRamus , Dmitry Bleklov , Sergey M. Plis , Vince D. Calhoun

Normative modelling is an emerging method for understanding the underlying heterogeneity within brain disorders like Alzheimer Disease (AD) by quantifying how each patient deviates from the expected normative pattern that has been learned…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data. However, conventional fusion approaches often rely on…

Machine Learning · Computer Science 2026-04-14 Farica Zhuang , Shu Yang , Dinara Aliyeva , Zixuan Wen , Duy Duong-Tran , Christos Davatzikos , Tianlong Chen , Song Wang , Li Shen

Normative models in neuroimaging learn the brain patterns of healthy population distribution and estimate how disease subjects like Alzheimer's Disease (AD) deviate from the norm. Existing variational autoencoder (VAE)-based normative…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

Multimodal remote sensing classification often suffers from missing modalities caused by sensor failures and environmental interference, leading to severe performance degradation. In this work, we rethink missing-modality learning from a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Qinghao Gao , Jiahui Qu , Wenqian Dong

Multi-modal learning has shown exceptional performance in various tasks, especially in medical applications, where it integrates diverse medical information for comprehensive diagnostic evidence. However, there still are several challenges…

Machine Learning · Computer Science 2024-11-19 Lin Fan , Yafei Ou , Cenyang Zheng , Pengyu Dai , Tamotsu Kamishima , Masayuki Ikebe , Kenji Suzuki , Xun Gong

Cross-modal Retrieval methods build similarity relations between vision and language modalities by jointly learning a common representation space. However, the predictions are often unreliable due to the Aleatoric uncertainty, which is…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Hao Li , Jingkuan Song , Lianli Gao , Xiaosu Zhu , Heng Tao Shen

As a crucial extension of entity alignment (EA), multi-modal entity alignment (MMEA) aims to identify identical entities across disparate knowledge graphs (KGs) by exploiting associated visual information. However, existing MMEA approaches…

Artificial Intelligence · Computer Science 2023-08-02 Zhuo Chen , Lingbing Guo , Yin Fang , Yichi Zhang , Jiaoyan Chen , Jeff Z. Pan , Yangning Li , Huajun Chen , Wen Zhang

Developing effective multimodal data fusion strategies has become increasingly essential for improving the predictive power of statistical machine learning methods across a wide range of applications, from autonomous driving to medical…

Machine Learning · Computer Science 2025-07-29 Ziyi Liang , Annie Qu , Babak Shahbaba

Normative modeling learns a healthy reference distribution and quantifies subject-specific deviations to capture heterogeneous disease effects. In Alzheimers disease (AD), multimodal neuroimaging offers complementary signals but VAE-based…

Machine Learning · Computer Science 2026-02-10 Sayantan Kumar , Peijie Qiu , Aristeidis Sotiras

Ophthalmologists typically require multimodal data sources to improve diagnostic accuracy in clinical decisions. However, due to medical device shortages, low-quality data and data privacy concerns, missing data modalities are common in…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Chengzhi Liu , Zile Huang , Zhe Chen , Feilong Tang , Yu Tian , Zhongxing Xu , Zihong Luo , Yalin Zheng , Yanda Meng

Audio and omni-modal large language models exhibit impressive cross-modal reasoning capabilities. However, applying standard reinforcement learning post-training algorithms to these models exposes a critical structural vulnerability:…

Computation and Language · Computer Science 2026-05-28 Cihan Xiao , Yiwen Shao , Chenxing Li , Xiang He , Zhenwen Liang , Steve Yves , Sanjeev Khudanpur , Liefeng Bo

Standard multi-modal models assume the use of the same modalities in training and inference stages. However, in practice, the environment in which multi-modal models operate may not satisfy such assumption. As such, their performances…

Computer Vision and Pattern Recognition · Computer Science 2023-03-31 Sangmin Woo , Sumin Lee , Yeonju Park , Muhammad Adi Nugroho , Changick Kim

Missing input sequences are common in medical imaging data, posing a challenge for deep learning models reliant on complete input data. In this work, inspired by MultiMAE [2], we develop a masked autoencoder (MAE) paradigm for multi-modal,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Ayhan Can Erdur , Christian Beischl , Daniel Scholz , Jiazhen Pan , Benedikt Wiestler , Daniel Rueckert , Jan C Peeken

Multimodal fusion is susceptible to modality imbalance, where dominant modalities overshadow weak ones, easily leading to biased learning and suboptimal fusion, especially for incomplete modality conditions. To address this problem, we…

Machine Learning · Computer Science 2026-03-20 Xiang Shi , Rui Zhang , Jiawei Liu , Yinpeng Liu , Qikai Cheng , Wei Lu

Multimodal Sentiment Analysis (MSA) aims to infer human sentiment from textual, acoustic, and visual signals. In real-world scenarios, however, multimodal inputs are often compromised by dynamic noise or modality missingness. Existing…

Artificial Intelligence · Computer Science 2026-04-09 Yitong Zhu , Yuxuan Jiang , Guanxuan Jiang , Bojing Hou , Peng Yuan Zhou , Ge Lin Kan , Yuyang Wang

Reliable Alzheimer's disease (AD) diagnosis increasingly relies on multimodal assessments combining structural Magnetic Resonance Imaging (MRI) and Electronic Health Records (EHR). However, deploying these models is bottlenecked by modality…

Computer Vision and Pattern Recognition · Computer Science 2026-03-04 Guanchen Wu , Zhe Huang , Yuzhang Xie , Runze Yan , Akul Chopra , Deqiang Qiu , Xiao Hu , Fei Wang , Carl Yang

Pre-trained vision language models have shown remarkable performance on visual recognition tasks, but they typically assume the availability of complete multimodal inputs during both training and inference. In real-world scenarios, however,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Shu Zhao , Nilesh Ahuja , Tan Yu , Tianyi Shen , Vijaykrishnan Narayanan

Making sense of multiple modalities can yield a more comprehensive description of real-world phenomena. However, learning the co-representation of diverse modalities is still a long-standing endeavor in emerging machine learning…

Artificial Intelligence · Computer Science 2022-12-21 Jinzhao Zhou , Yiqun Duan , Zhihong Chen , Yu-Cheng Chang , Chin-Teng Lin

Diagnosing dementia, particularly for Alzheimer's Disease (AD) and frontotemporal dementia (FTD), is complex due to overlapping symptoms. While magnetic resonance imaging (MRI) and positron emission tomography (PET) data are critical for…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Yitong Li , Morteza Ghahremani , Youssef Wally , Christian Wachinger