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Advancements in high-throughput technologies have led to a shift from traditional hypothesis-driven methodologies to data-driven approaches. Multi-omics refers to the integrative analysis of data derived from multiple 'omes', such as…

Genomics · Quantitative Biology 2024-10-17 Ahmad Hussein , Mukesh Prasad , Ali Braytee

Inference is crucial in modern astronomical research, where hidden astrophysical features and patterns are often estimated from indirect and noisy measurements. Inferring the posterior of hidden features, conditioned on the observed…

Instrumentation and Methods for Astrophysics · Physics 2022-06-29 He Sun , Katherine L. Bouman , Paul Tiede , Jason J. Wang , Sarah Blunt , Dimitri Mawet

Many models in natural language processing define probabilistic distributions over linguistic structures. We argue that (1) the quality of a model' s posterior distribution can and should be directly evaluated, as to whether probabilities…

Computation and Language · Computer Science 2015-09-03 Khanh Nguyen , Brendan O'Connor

The trustworthiness of neural networks is often challenged because they lack the ability to express uncertainty and explain their skill. This can be problematic given the increasing use of neural networks in high stakes decision-making such…

Atmospheric and Oceanic Physics · Physics 2022-12-07 Mariana C. A. Clare , Maike Sonnewald , Redouane Lguensat , Julie Deshayes , Venkatramani Balaji

Deep neural networks are revolutionizing the way complex systems are developed. However, these automatically-generated networks are opaque to humans, making it difficult to reason about them and guarantee their correctness. Here, we propose…

Artificial Intelligence · Computer Science 2020-08-11 Yuval Jacoby , Clark Barrett , Guy Katz

Simulation-based inference (SBI) is an established approach for performing Bayesian inference on scientific simulators. SBI so far works best on low-dimensional parametric models. However, it is difficult to infer function-valued…

Machine Learning · Computer Science 2025-11-17 Guy Moss , Leah Sophie Muhle , Reinhard Drews , Jakob H. Macke , Cornelius Schröder

In this paper we examine the problem of inference in Bayesian Networks with discrete random variables that have very large or even unbounded domains. For example, in a domain where we are trying to identify a person, we may have variables…

Artificial Intelligence · Computer Science 2012-12-12 Rita Sharma , David L Poole

We consider the optimization of an uncertain objective over continuous and multi-dimensional decision spaces in problems in which we are only provided with observational data. We propose a novel algorithmic framework that is tractable,…

Machine Learning · Statistics 2018-10-30 Dimitris Bertsimas , Christopher McCord

An important challenge in statistical analysis lies in controlling the estimation bias when handling the ever-increasing data size and model complexity of modern data settings. In this paper, we propose a reliable estimation and inference…

Mutual information (MI) is a fundamental measure of statistical dependence between two variables, yet accurate estimation from finite data remains notoriously difficult. No estimator is universally reliable, and common approaches fail in…

Data Analysis, Statistics and Probability · Physics 2025-10-02 Eslam Abdelaleem , K. Michael Martini , Ilya Nemenman

Explainable AI (XAI) aims to provide interpretations for predictions made by learning machines, such as deep neural networks, in order to make the machines more transparent for the user and furthermore trustworthy also for applications in…

Machine Learning · Computer Science 2020-06-17 Kirill Bykov , Marina M. -C. Höhne , Klaus-Robert Müller , Shinichi Nakajima , Marius Kloft

We show a proof of principle for warping, a method to interpret the inner working of neural networks in the context of gene expression analysis. Warping is an efficient way to gain insight to the inner workings of neural nets and make them…

Genomics · Quantitative Biology 2017-08-17 Trofimov Assya , Lemieux Sebastien , Perreault Claude

Methods for understanding the decisions of and mechanisms underlying deep neural networks (DNNs) typically rely on building intuition by emphasizing sensory or semantic features of individual examples. For instance, methods aim to visualize…

Computers and Society · Computer Science 2020-10-26 Matthew L. Leavitt , Ari Morcos

We present probabilistic neural programs, a framework for program induction that permits flexible specification of both a computational model and inference algorithm while simultaneously enabling the use of deep neural networks.…

Neural and Evolutionary Computing · Computer Science 2016-12-05 Kenton W. Murray , Jayant Krishnamurthy

The last decades saw dramatic progress in brain research. These advances were often buttressed by probing single variables to make circumscribed discoveries, typically through null hypothesis significance testing. New ways for generating…

Neurons and Cognition · Quantitative Biology 2019-03-26 Danilo Bzdok , John Ioannidis

Robust Ordinal Regression (ROR) is a way of dealing with Multiple Criteria Decision Aiding (MCDA), by considering all sets of parameters of an assumed preference model, that are compatible with preference information given by the Decision…

Optimization and Control · Mathematics 2012-06-28 Salvatore Corrente , Salvatore Greco , Roman Slowinski

Faster inference of deep learning models is highly demanded on edge devices and even servers, for both financial and environmental reasons. To address this issue, we propose SoftNeuro, a novel, high-performance inference framework with…

Machine Learning · Computer Science 2021-10-13 Masaki Hilaga , Yasuhiro Kuroda , Hitoshi Matsuo , Tatsuya Kawaguchi , Gabriel Ogawa , Hiroshi Miyake , Yusuke Kozawa

Count data are collected in many scientific and engineering tasks including image processing, single-cell RNA sequencing and ecological studies. Such data sets often contain missing values, for example because some ecological sites cannot…

Methodology · Statistics 2018-10-25 Geneviève Robin , Julie Josse , Eric Moulines , Sylvain Sardy

The inability of artificial neural networks to assess the uncertainty of their predictions is an impediment to their widespread use. We distinguish two types of learnable uncertainty: model uncertainty due to a lack of training data and…

Machine Learning · Computer Science 2022-06-14 Hans Weytjens , Jochen De Weerdt

We introduce universal neural likelihood inference (UNLI): enabling a single model to provide data-grounded, conditional likelihood predictions for arbitrary targets given any collection of observed features, across diverse domains and…

Machine Learning · Computer Science 2026-02-05 Shreyas Bhat Brahmavar , Yang Li , Qiyang Liu , Shashank Srivastava , Junier Oliva