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We develop nested variational inference (NVI), a family of methods that learn proposals for nested importance samplers by minimizing an forward or reverse KL divergence at each level of nesting. NVI is applicable to many commonly-used…

Machine Learning · Statistics 2021-06-22 Heiko Zimmermann , Hao Wu , Babak Esmaeili , Jan-Willem van de Meent

The integration of deep learning approaches in biomedical research has been transformative, enabling breakthroughs in various applications. Despite these strides, its application in protein inference is impeded by the scarcity of…

Machine Learning · Computer Science 2026-05-07 Zheng Ma , Jiazhen Chen , Lei Xin , Ali Ghodsi

Bayesian inference for complex models with an intractable likelihood can be tackled using algorithms performing many calls to computer simulators. These approaches are collectively known as "simulation-based inference" (SBI). Recent SBI…

Reconstructing the structural connectivity between interacting units from observed activity is a challenge across many different disciplines. The fundamental first step is to establish whether or to what extent the interactions between the…

Neurons and Cognition · Quantitative Biology 2016-11-02 Elliot A. Martin , Jaroslav Hlinka , Jörn Davidsen

In this paper the application of uncertainty modeling to convolutional neural networks is evaluated. A novel method for adjusting the network's predictions based on uncertainty information is introduced. This allows the network to be either…

Computer Vision and Pattern Recognition · Computer Science 2016-12-23 Rene Grzeszick , Sebastian Sudholt , Gernot A. Fink

Given a set of human's decisions that are observed, inverse optimization has been developed and utilized to infer the underlying decision making problem. The majority of existing studies assumes that the decision making problem is with a…

Machine Learning · Statistics 2018-08-03 Chaosheng Dong , Bo Zeng

Neural Processes (NPs) are deep probabilistic models that represent stochastic processes by conditioning their prior distributions on a set of context points. Despite their advantages in uncertainty estimation for complex distributions, NPs…

Machine Learning · Computer Science 2025-06-04 Xuesong Wang , He Zhao , Edwin V. Bonilla

Forensic examination of evidence like firearms and toolmarks, traditionally involves a visual and therefore subjective assessment of similarity of two questioned items. Statistical models are used to overcome this subjectivity and allow…

Human-Computer Interaction · Computer Science 2021-11-03 Ganesh Krishnan , Heike Hofmann

The analysis of decision making under uncertainty is closely related to the analysis of probabilistic inference. Indeed, much of the research into efficient methods for probabilistic inference in expert systems has been motivated by the…

Artificial Intelligence · Computer Science 2013-03-25 Ross D. Shachter , Mark Alan Peot

Bayesian networks (BNs) are attractive, because they are graphical and interpretable machine learning models. However, exact inference on BNs is time-consuming, especially for complex problems. To improve the efficiency, we propose a fast…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-03-14 Jiantong Jiang , Zeyi Wen , Atif Mansoor , Ajmal Mian

Advances in neural imaging have enabled neuroscientists to study how large neural populations conspire to produce perception, behavior and cognition. Despite many advances in optical methods, there exists a fundamental tradeoff between…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Esther Whang , Skyler Thomas , Ji Yi , Adam S. Charles

Approximate variational inference has shown to be a powerful tool for modeling unknown complex probability distributions. Recent advances in the field allow us to learn probabilistic models of sequences that actively exploit spatial and…

Machine Learning · Statistics 2016-06-15 Maximilian Soelch , Justin Bayer , Marvin Ludersdorfer , Patrick van der Smagt

Natural Language Inference (NLI) aims to determine the logic relationships (i.e., entailment, neutral and contradiction) between a pair of premise and hypothesis. Recently, the alignment mechanism effectively helps NLI by capturing the…

Computation and Language · Computer Science 2019-11-12 Zhen Cheng , Zaixiang Zheng , Xin-Yu Dai , Shujian Huang , Jiajun Chen

Attempts to replicate probabilistic reasoning in expert systems have typically overlooked a critical ingredient of that process. Probabilistic analysis typically requires extensive judgments regarding interdependencies among hypotheses and…

Artificial Intelligence · Computer Science 2013-04-15 Marvin S. Cohen

Despite the promise of Neural Posterior Estimation (NPE) methods in astronomy, the adaptation of NPE into the routine inference workflow has been slow. We identify three critical issues: the need for custom featurizer networks tailored to…

Instrumentation and Methods for Astrophysics · Physics 2023-12-25 Keming Zhang , Joshua S. Bloom , Stéfan van der Walt , Nina Hernitschek

High degrees of disagreement among annotators can exist for ambiguous objects, e.g. in medical images, underscoring the challenges of establishing ground truth annotations in object detection tasks. Despite this, all existing object…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Zhi Qin Tan , Owen Addison , Yunpeng Li

Robust environment perception is essential for decision-making on robots operating in complex domains. Principled treatment of uncertainty sources in a robot's observation model is necessary for accurate mapping and object detection. This…

Computer Vision and Pattern Recognition · Computer Science 2016-07-15 Shayegan Omidshafiei , Brett T. Lopez , Jonathan P. How , John Vian

We devise a novel inference algorithm to effectively solve the cancer progression model reconstruction problem. Our empirical analysis of the accuracy and convergence rate of our algorithm, CAncer PRogression Inference (CAPRI), shows that…

A grand challenge in machine learning is the development of computational algorithms that match or outperform humans in perceptual inference tasks that are complicated by nuisance variation. For instance, visual object recognition involves…

Machine Learning · Statistics 2015-04-03 Ankit B. Patel , Tan Nguyen , Richard G. Baraniuk

Existing methods for estimating uncertainty in deep learning tend to require multiple forward passes, making them unsuitable for applications where computational resources are limited. To solve this, we perform probabilistic reasoning over…

Machine Learning · Statistics 2020-12-08 Javier Antorán , James Urquhart Allingham , José Miguel Hernández-Lobato