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Building precise simulations of the real world and invoking numerical solvers to answer quantitative problems is an essential requirement in engineering and science. We present FEABench, a benchmark to evaluate the ability of large language…

Artificial Intelligence · Computer Science 2025-04-09 Nayantara Mudur , Hao Cui , Subhashini Venugopalan , Paul Raccuglia , Michael P. Brenner , Peter Norgaard

The ability to distinguish subtle differences between visually similar images is essential for diverse domains such as industrial anomaly detection, medical imaging, and aerial surveillance. While comparative reasoning benchmarks for…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Minkyu Kim , Sangheon Lee , Dongmin Park

Unlocking the next generation of biotechnology and therapeutic innovation demands overcoming the inherent complexity and resource-intensity of conventional protein engineering methods. Recent GenAI-powered computational techniques often…

The modeling of bio-molecular system across molecular scales remains a central challenge in scientific research. Large language models (LLMs) are increasingly applied to bio-molecular discovery, yet systematic evaluation across multi-scale…

Machine Learning · Computer Science 2026-04-07 Yaxin Xu , Yue Zhou , Tianyu Zhao , Fengwei An , Zhixiang Ren

Recent advances in multimodal large language models (LLMs) have highlighted their potential for medical and surgical applications. However, existing surgical datasets predominantly adopt a Visual Question Answering (VQA) format with…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Tae-Min Choi , Tae Kyeong Jeong , Garam Kim , Jaemin Lee , Yeongyoon Koh , In Cheul Choi , Jae-Ho Chung , Jong Woong Park , Juyoun Park

Large multimodal models (LMMs) have recently gained attention due to their effectiveness to understand and generate descriptions of visual content. Most existing LMMs are in English language. While few recent works explore multilingual…

Large language models are now integrated into many scientific workflows, accelerating data analysis, hypothesis generation, and design space exploration. In parallel with this growth, there is a growing need to carefully evaluate whether…

We present a new approach for benchmarking Large Language Model (LLM) capabilities on research-level mathematics. Existing benchmarks largely rely on static, hand-curated sets of contest or textbook-style problems as proxies for…

Artificial Intelligence · Computer Science 2026-03-02 Antoine Peyronnet , Fabian Gloeckle , Amaury Hayat

Although large visual-language models (LVLMs) have demonstrated strong performance in multimodal tasks, errors may occasionally arise due to biases during the reasoning process. Recently, reward models (RMs) have become increasingly pivotal…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Jiacheng Ruan , Wenzhen Yuan , Xian Gao , Ye Guo , Daoxin Zhang , Zhe Xu , Yao Hu , Ting Liu , Yuzhuo Fu

Joint vision-language models have shown great performance over a diverse set of tasks. However, little is known about their limitations, as the high dimensional space learned by these models makes it difficult to identify semantic errors.…

Computer Vision and Pattern Recognition · Computer Science 2023-06-01 Santiago Castro , Oana Ignat , Rada Mihalcea

Protein language models (pLMs) have shown strong potential for zero-shot prediction of missense variant effects, yet systematic benchmarking on viral proteins remains limited, a critical gap given the need for proactive tools that can…

Quantitative Methods · Quantitative Biology 2026-05-20 Yichen Zhou , Jonathan Golob , Amir Karimi , Stefan Bauer , Patrick Schwab

Large language models (LLMs) have demonstrated several emergent behaviors with scale, including reasoning and fluency in long-form text generation. However, they continue to struggle with tasks requiring precise spatial and positional…

Machine Learning · Computer Science 2025-12-05 Kerry Luo , Michael Fu , Joshua Peguero , Husnain Malik , Anvay Patil , Joyce Lin , Megan Van Overborg , Ryan Sarmiento , Kevin Zhu

Video generation assessment is essential for ensuring that generative models produce visually realistic, high-quality videos while aligning with human expectations. Current video generation benchmarks fall into two main categories:…

Computer Vision and Pattern Recognition · Computer Science 2025-04-30 Hui Han , Siyuan Li , Jiaqi Chen , Yiwen Yuan , Yuling Wu , Chak Tou Leong , Hanwen Du , Junchen Fu , Youhua Li , Jie Zhang , Chi Zhang , Li-jia Li , Yongxin Ni

Deep learning has transformed protein design, enabling accurate structure prediction, sequence optimization, and de novo protein generation. Advances in single-chain protein structure prediction via AlphaFold2, RoseTTAFold, ESMFold, and…

Machine Learning · Computer Science 2025-02-27 Gregory W. Kyro , Tianyin Qiu , Victor S. Batista

There is a pressing need for better development methods and tools to keep up with the growing demand and increasing complexity of new software systems. New types of user interfaces, the need for intelligent components, sustainability…

Software Engineering · Computer Science 2026-04-14 Jordi Cabot

While large language models (LLMs) have shown remarkable potential in automating various tasks in digital chip design, the field of Photonic Integrated Circuits (PICs)-a promising solution to advanced chip designs-remains relatively…

Machine Learning · Computer Science 2025-02-07 Yuchao Wu , Xiaofei Yu , Hao Chen , Yang Luo , Yeyu Tong , Yuzhe Ma

The biomedical domain has sparked a significant interest in the field of Natural Language Processing (NLP), which has seen substantial advancements with pre-trained language models (PLMs). However, comparing these models has proven…

Despite the transformative potential of Large Language Models (LLMs) in hardware design, a comprehensive evaluation of their capabilities in design verification remains underexplored. Current efforts predominantly focus on RTL generation…

Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…

Soft Condensed Matter · Physics 2024-02-08 A. Ghafarollahi , M. J. Buehler

Current benchmarks for Large Language Models (LLMs) primarily focus on performance metrics, often failing to capture the nuanced behavioral characteristics that differentiate them. This paper introduces a novel ``Behavioral Fingerprinting''…

Computation and Language · Computer Science 2025-09-08 Zehua Pei , Hui-Ling Zhen , Ying Zhang , Zhiyuan Yang , Xing Li , Xianzhi Yu , Mingxuan Yuan , Bei Yu