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Protein design aims to compose amino-acid sequences that fold into stable three-dimensional structures while satisfying targeted functional properties. The field is increasingly shifting toward vibe protein design, where a single model is…

We introduce ISO-Bench, a benchmark for coding agents to test their capabilities on real-world inference optimization tasks. These tasks were taken from vLLM and SGLang, two of the most popular LLM serving frameworks. Each task provides an…

Machine Learning · Computer Science 2026-02-24 Ayush Nangia , Shikhar Mishra , Aman Gokrani , Paras Chopra

The rapid evolution of Multi-modality Large Language Models (MLLMs) has catalyzed a shift in computer vision from specialized models to general-purpose foundation models. Nevertheless, there is still an inadequacy in assessing the abilities…

Computer Vision and Pattern Recognition · Computer Science 2024-01-02 Haoning Wu , Zicheng Zhang , Erli Zhang , Chaofeng Chen , Liang Liao , Annan Wang , Chunyi Li , Wenxiu Sun , Qiong Yan , Guangtao Zhai , Weisi Lin

The adoption of machine learning (ML) and deep learning methods has revolutionized molecular medicine by driving breakthroughs in genomics, transcriptomics, drug discovery, and biological systems modeling. The increasing quantity,…

While Large Language Models (LLMs) show significant potential in hardware engineering, current benchmarks suffer from saturation and limited task diversity, failing to reflect LLMs' performance in real industrial workflows. To address this…

Artificial Intelligence · Computer Science 2026-02-03 Zhongkai Yu , Chenyang Zhou , Yichen Lin , Hejia Zhang , Haotian Ye , Junxia Cui , Zaifeng Pan , Jishen Zhao , Yufei Ding

Nucleotide sequences constitute the fundamental genetic basis of biological systems, rendering viral genomic analysis critical for biomedical advancement. Despite progress in biological foundation models, specifically nucleotide foundation…

Machine Learning · Computer Science 2026-05-26 Dongxin Ye , Fang Hu , Han Hu , Shu Hu , Yang Tan , Wanli Ouyang , Stan Z. Li , Jie Cui , Nanqing Dong

We introduce AInsteinBench, a large-scale benchmark for evaluating whether large language model (LLM) agents can operate as scientific computing development agents within real research software ecosystems. Unlike existing scientific…

Recent large language models (LLMs) have demonstrated significant advancements, particularly in their ability to serve as agents thereby surpassing their traditional role as chatbots. These agents can leverage their planning and tool…

Machine Learning · Computer Science 2025-02-13 Yixing Jiang , Kameron C. Black , Gloria Geng , Danny Park , James Zou , Andrew Y. Ng , Jonathan H. Chen

Large Language Models (LLMs) and Large Vision-Language Models (LVLMs) have demonstrated impressive language/vision reasoning abilities, igniting the recent trend of building agents for targeted applications such as shopping assistants or AI…

Artificial Intelligence · Computer Science 2025-04-14 Liqiang Jing , Zhehui Huang , Xiaoyang Wang , Wenlin Yao , Wenhao Yu , Kaixin Ma , Hongming Zhang , Xinya Du , Dong Yu

The advances made by Large Language Models (LLMs) have led to the pursuit of LLM agents that can solve intricate, multi-step reasoning tasks. As with any research pursuit, benchmarking and evaluation are key corner stones to efficient and…

Artificial Intelligence · Computer Science 2024-04-10 Luca Gioacchini , Giuseppe Siracusano , Davide Sanvito , Kiril Gashteovski , David Friede , Roberto Bifulco , Carolin Lawrence

Recent advancements in machine learning have significantly improved the identification of disease-associated genes from gene expression datasets. However, these processes often require extensive expertise and manual effort, limiting their…

Machine Learning · Computer Science 2025-04-09 Haoyang Liu , Shuyu Chen , Ye Zhang , Haohan Wang

Medical imaging benchmarks often evaluate VLMs on pre-selected 2D images, slices, crops, or patches, making evaluation closer to visual recognition. Real clinical workflows impose a different burden: readers must search through complete…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Weixiang Shen , Chengzhi Shen , Yanzhu Hu , Che Liu , Junde Wu , Jiayuan Zhu , Xiao Han , Zongyue Li , Jingpei Wu , Min Xu , Daguang Xu , Yueming Jin , Benedikt Wiestler , Daniel Rueckert , Jiazhen Pan

As LLMs achieved breakthroughs in general reasoning, their proficiency in specialized scientific domains reveals pronounced gaps in existing benchmarks due to data contamination, insufficient complexity, and prohibitive human labor costs.…

Artificial Intelligence · Computer Science 2026-02-27 Peiyao Xiao , Xiaogang Li , Chengliang Xu , Jiayi Wang , Ben Wang , Zichao Chen , Zeyu Wang , Kejun Yu , Yueqian Chen , Xulin Liu , Wende Xiao , Bing Zhao , Hu Wei

The generative capabilities of Large Language Models (LLMs) are rapidly expanding from static code to dynamic, interactive visual artifacts. This progress is bottlenecked by a critical evaluation gap: established benchmarks focus on…

Large vision-language models (LVLMs) exhibit remarkable capabilities in cross-modal tasks but face significant safety challenges, which undermine their reliability in real-world applications. Efforts have been made to build LVLM safety…

Computation and Language · Computer Science 2026-01-28 Xiangyang Zhu , Yuan Tian , Zicheng Zhang , Qi Jia , Chunyi Li , Renrui Zhang , Heng Li , Zongrui Wang , Wei Sun

LLMs have achieved significant performance progress in various NLP applications. However, LLMs still struggle to meet the strict requirements for accuracy and reliability in the medical field and face many challenges in clinical…

Computation and Language · Computer Science 2024-10-11 Weixiang Yan , Haitian Liu , Tengxiao Wu , Qian Chen , Wen Wang , Haoyuan Chai , Jiayi Wang , Weishan Zhao , Yixin Zhang , Renjun Zhang , Li Zhu , Xuandong Zhao

Multimodal Large Language Models (MLLMs) are increasingly applied in Personalized Image Aesthetic Assessment (PIAA) as a scalable alternative to expert evaluations. However, their predictions may reflect subtle biases influenced by…

Computation and Language · Computer Science 2025-09-16 Kun Li , Lai-Man Po , Hongzheng Yang , Xuyuan Xu , Kangcheng Liu , Yuzhi Zhao

As multimodal large language models (MLLMs) advance, MLLM-based virtual agents have demonstrated remarkable performance. However, existing benchmarks face significant limitations, including uncontrollable task complexity, extensive manual…

Computer Vision and Pattern Recognition · Computer Science 2025-06-11 Wendong Bu , Yang Wu , Qifan Yu , Minghe Gao , Bingchen Miao , Zhenkui Zhang , Kaihang Pan , Yunfei Li , Mengze Li , Wei Ji , Juncheng Li , Siliang Tang , Yueting Zhuang

Autonomous agents powered by large language models (LLMs) promise to accelerate scientific discovery end-to-end, but rigorously evaluating their capacity for verifiable discovery remains a central challenge. Existing benchmarks face a…

Artificial Intelligence · Computer Science 2026-02-04 Zhen Wang , Fan Bai , Zhongyan Luo , Jinyan Su , Kaiser Sun , Xinle Yu , Jieyuan Liu , Kun Zhou , Claire Cardie , Mark Dredze , Eric P. Xing , Zhiting Hu

We introduce PhysicianBench, a benchmark for evaluating LLM agents on physician tasks grounded in real clinical setting within electronic health record (EHR) environments. Existing medical agent benchmarks primarily focus on static…