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Machine Learning-assisted directed evolution (MLDE) is a powerful tool for efficiently navigating antibody fitness landscapes. Many structure-aware MLDE pipelines rely on a single conformation or a single committee across all conformations,…

Machine Learning · Computer Science 2025-12-03 Mia Adler , Carrie Liang , Brian Peng , Oleg Presnyakov , Justin M. Baker , Jannelle Lauffer , Himani Sharma , Barry Merriman

We present the quantum-selected configuration interaction-tailored coupled-cluster (QSCI-TCC) method, a hybrid quantum-classical scheme that tailors coupled-cluster (CC) theory with a quantum-selected configuration interaction (QSCI) wave…

Chemical Physics · Physics 2025-06-23 Luca Erhart , Yuichiro Yoshida , Wataru Mizukami

Large language models can fail in critic interaction not only by answering incorrectly, but also by abandoning an initially correct scientific solution after user criticism. This is especially risky in scientific reasoning, where user…

Machine Learning · Computer Science 2026-05-20 Wanghan Xu , Yuhao Zhou , Hengyuan Zhao , Shuo Li , Dianzhi Yu , Zhenfei Yin , Yaowen Hu , Fengli Xu , Wanli Ouyang , Wenlong Zhang , Lei Bai

Diffusion-based Molecular Communication (MC) is inherently challenged by severe inter-symbol interference (ISI). This is significantly amplified in mobile scenarios, where the channel impulse response (CIR) becomes time-varying and…

Emerging Technologies · Computer Science 2025-11-13 Abdulkadir Bilge , Eren Akyol , Murat Kuscu

Enabling multiple autonomous machines to perform reliably requires the development of efficient cooperative control algorithms. This paper presents a survey of algorithms that have been developed for controlling and coordinating autonomous…

Reranking improves recommendation quality by modeling item interactions. However, existing methods often decouple ranking and reranking, leading to weak listwise evaluation models that suffer from combinatorial sparsity and limited…

Information Retrieval · Computer Science 2025-11-27 Guoxiao Zhang , Tan Qu , Ao Li , DongLin Ni , Qianlong Xie , Xingxing Wang

We present three modifications to our recently introduced fast randomized iteration method for full configuration interaction (FCI-FRI) and investigate their effects on the method's performance for Ne, H$_2$O, and N$_2$. The initiator…

Computational Physics · Physics 2023-10-03 Samuel M. Greene , Robert J. Webber , Jonathan Weare , Timothy C. Berkelbach

This paper introduces Relative Predictive Coding (RPC), a new contrastive representation learning objective that maintains a good balance among training stability, minibatch size sensitivity, and downstream task performance. The key to the…

Machine Learning · Computer Science 2021-04-14 Yao-Hung Hubert Tsai , Martin Q. Ma , Muqiao Yang , Han Zhao , Louis-Philippe Morency , Ruslan Salakhutdinov

We have combined our adaptive configuration interaction (ACI) [J.B. Schriber and F.A. Evangelista, J. Chem. Phys. 144, 161106 (2016)] with a density-fitted implementation of the second-order perturbative multireference driven similarity…

Chemical Physics · Physics 2018-08-29 Jeffrey B. Schriber , Kevin P. Hannon , Francesco A. Evangelista

As the final stage of the multi-stage recommender system (MRS), reranking directly affects users' experience and satisfaction, thus playing a critical role in MRS. Despite the improvement achieved in the existing work, three issues are yet…

Information Retrieval · Computer Science 2022-04-21 Yunjia Xi , Weiwen Liu , Jieming Zhu , Xilong Zhao , Xinyi Dai , Ruiming Tang , Weinan Zhang , Rui Zhang , Yong Yu

An externally corrected coupled cluster (CC) method, where an adaptive configuration interaction (ACI) wave function provides the external cluster amplitudes, named ACI-CC, is presented. By exploiting the connection between configuration…

Chemical Physics · Physics 2023-09-27 Gustavo J. R. Aroeira , Madeline M. Davis , Justin M. Turney , Henry F. Schaefer

Existing research efforts for multi-interest candidate matching in recommender systems mainly focus on improving model architecture or incorporating additional information, neglecting the importance of training schemes. This work revisits…

Information Retrieval · Computer Science 2023-08-01 Yueqi Xie , Jingqi Gao , Peilin Zhou , Qichen Ye , Yining Hua , Jaeboum Kim , Fangzhao Wu , Sunghun Kim

Industrial ranking systems, such as advertising systems, rank items by aggregating multiple objectives into one final objective to satisfy user demand and commercial intent. Cascade architecture, composed of retrieval, pre-ranking, and…

Information Retrieval · Computer Science 2022-11-04 Siyu Gu , Xiangrong Sheng

Proactive intent prediction is a critical capability in modern e-commerce chatbots, enabling "zero-query" recommendations by anticipating user needs from behavioral and contextual signals. However, existing industrial systems face two…

Information Retrieval · Computer Science 2026-02-16 Junhua Liu , Yang Jihao , Cheng Chang , Kunrong LI , Bin Fu , Kwan Hui Lim

Contrastive representation learning seeks to acquire useful representations by estimating the shared information between multiple views of data. Here, the choice of data augmentation is sensitive to the quality of learned representations:…

Machine Learning · Statistics 2023-01-18 Kyungmin Lee , Jinwoo Shin

Computational protein-protein interaction (PPI) prediction techniques can contribute greatly in reducing time, cost and false-positive interactions compared to experimental approaches. Sequence is one of the key and primary information of…

Machine Learning · Computer Science 2022-03-29 Soumyadeep Debnath , Ayatullah Faruk Mollah

Deep regression models typically learn in an end-to-end fashion without explicitly emphasizing a regression-aware representation. Consequently, the learned representations exhibit fragmentation and fail to capture the continuous nature of…

Machine Learning · Computer Science 2023-10-11 Kaiwen Zha , Peng Cao , Jeany Son , Yuzhe Yang , Dina Katabi

The Configuration Interaction (CI) method using orbitals centered on the nucleus has recently been applied to calculate the interactions of positrons interacting with atoms. Computational investigations of the convergence properties of…

Atomic Physics · Physics 2007-05-23 J. Mitroy , M. W. J. Bromley

Compound-Protein Interaction (CPI) prediction aims to predict the pattern and strength of compound-protein interactions for rational drug discovery. Existing deep learning-based methods utilize only the single modality of protein sequences…

Biomolecules · Quantitative Biology 2024-02-14 Lirong Wu , Yufei Huang , Cheng Tan , Zhangyang Gao , Bozhen Hu , Haitao Lin , Zicheng Liu , Stan Z. Li

Although conceptually related, variable selection and relative importance (RI) analysis have been treated quite differently in the literature. While RI is typically used for post-hoc model explanation, this paper explores its potential for…

Machine Learning · Statistics 2026-04-24 Tien-En Chang , Argon Chen
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