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Clinical trials are critical for advancing medical treatments but remain prohibitively expensive and time-consuming. Accurate prediction of clinical trial outcomes can significantly reduce research and development costs and accelerate drug…

Machine Learning · Computer Science 2025-06-06 Fengze Liu , Haoyu Wang , Joonhyuk Cho , Dan Roth , Andrew W. Lo

Can we leverage LLMs to model the process of discovering novel language model (LM) architectures? Inspired by real research, we propose a multi-agent LLM approach that simulates the conventional stages of research, from ideation and…

Artificial Intelligence · Computer Science 2025-06-26 Junyan Cheng , Peter Clark , Kyle Richardson

The performance of large language models (LLMs) depends on how they are prompted, with choices spanning both the high-level prompting pattern (e.g., Zero-Shot, CoT, ReAct, ReWOO) and the specific prompt content (instructions and few-shot…

Machine Learning · Computer Science 2025-11-05 Claudio Spiess , Mandana Vaziri , Louis Mandel , Martin Hirzel

Historically, scientific discovery has been a lengthy and costly process, demanding substantial time and resources from initial conception to final results. To accelerate scientific discovery, reduce research costs, and improve research…

Human-Computer Interaction · Computer Science 2025-06-18 Samuel Schmidgall , Yusheng Su , Ze Wang , Ximeng Sun , Jialian Wu , Xiaodong Yu , Jiang Liu , Michael Moor , Zicheng Liu , Emad Barsoum

The reasoning capabilities of large language models (LLMs) have significantly advanced their performance by enabling in-depth understanding of diverse tasks. With growing interest in applying LLMs to the time series domain, this has proven…

Artificial Intelligence · Computer Science 2025-06-03 Jiahui Zhou , Dan Li , Lin Li , Zhuomin Chen , Shunyu Wu , Haozheng Ye , Jian Lou , Costas J. Spanos

The inherent capabilities of a language model (LM) and the reasoning strategies it employs jointly determine its performance in reasoning tasks. While test-time scaling is regarded as an effective approach to tackling complex reasoning…

Computation and Language · Computer Science 2025-05-27 Zhihong Pan , Kai Zhang , Yuze Zhao , Yupeng Han

Large language Model (LLM)-assisted algorithm discovery is an iterative, black-box optimization process over programs to approximatively solve a target task, where an LLM proposes candidate programs and an external evaluator provides task…

Machine Learning · Computer Science 2026-02-04 Timothee Leleu , Sudeera Gunathilaka , Federico Ghimenti , Surya Ganguli

Large Language Models (LLMs) often exhibit strong linguistic abilities while remaining unreliable on multi-step reasoning tasks, particularly when deployed without additional training or fine-tuning. In this work, we study inference-time…

Computation and Language · Computer Science 2026-03-24 Vinay Sharma , Manish Jain

Large language models (LLMs) have recently achieved remarkable results in complex multi-step tasks, such as mathematical reasoning and agentic software engineering. However, they often struggle to maintain consistent performance across…

Recent advancements in software engineering agents have demonstrated promising capabilities in automating program improvements. However, their reliance on closed-source or resource-intensive models introduces significant deployment…

Software Engineering · Computer Science 2025-04-09 Yingwei Ma , Yongbin Li , Yihong Dong , Xue Jiang , Rongyu Cao , Jue Chen , Fei Huang , Binhua Li

Recently, test-time scaling has garnered significant attention from the research community, largely due to the substantial advancements of the o1 model released by OpenAI. By allocating more computational resources during the inference…

The rapid advancement of large language models (LLMs) has enabled role-playing language agents to demonstrate significant potential in various applications. However, relying solely on prompts and contextual inputs often proves insufficient…

Computation and Language · Computer Science 2025-07-24 Xiaoyu Zhan , Xinyu Fu , Hao Sun , Yuanqi Li , Jie Guo , Yanwen Guo

The combination of LLM agents with external tools enables models to solve complex tasks beyond their knowledge base. Human-designed tools are inflexible and restricted to solutions within the scope of pre-existing tools created by experts.…

Artificial Intelligence · Computer Science 2025-11-18 Mohd Ariful Haque , Justin Williams , Sunzida Siddique , Md. Hujaifa Islam , Hasmot Ali , Kishor Datta Gupta , Roy George

With the continuous advancement of Large Language Models (LLMs), intelligent agents are becoming increasingly vital. However, these agents often fail in environments governed by implicit rules--hidden constraints that cannot be observed…

Artificial Intelligence · Computer Science 2026-05-26 Wentong Chen , Xin Cong , Zhong Zhang , Yaxi Lu , Siyuan Zhao , Yesai Wu , Qinyu Luo , Haotian Chen , Yankai Lin , Zhiyuan Liu , Maosong Sun

Recent advances in large language models (LLMs) have propelled research in natural language interfaces to databases. However, most state-of-the-art text-to-SQL systems still depend on complex, multi-stage pipelines. This work proposes a…

Artificial Intelligence · Computer Science 2025-06-03 Fernando Granado , Roberto Lotufo , Jayr Pereira

Large language models (LLMs) have dramatically enhanced the field of language intelligence, as demonstrably evidenced by their formidable empirical performance across a spectrum of complex reasoning tasks. Additionally, theoretical proofs…

Computation and Language · Computer Science 2023-11-21 Zhuosheng Zhang , Yao Yao , Aston Zhang , Xiangru Tang , Xinbei Ma , Zhiwei He , Yiming Wang , Mark Gerstein , Rui Wang , Gongshen Liu , Hai Zhao

Most existing prompting methods suffer from the issues of generalizability and consistency, as they often rely on instance-specific solutions that may not be applicable to other instances and lack task-level consistency across the selected…

Computation and Language · Computer Science 2024-11-12 Chang Gao , Haiyun Jiang , Deng Cai , Shuming Shi , Wai Lam

As LLMs are increasingly deployed as agents, agentic reasoning - the ability to combine tool use, especially search, and reasoning - becomes a critical skill. However, it is hard to disentangle agentic reasoning when evaluated in complex…

Artificial Intelligence · Computer Science 2025-10-03 Hanlin Zhu , Tianyu Guo , Song Mei , Stuart Russell , Nikhil Ghosh , Alberto Bietti , Jiantao Jiao

Test-Time Scaling (TTS) improves the performance of Large Language Models (LLMs) by using additional inference-time computation to explore multiple reasoning paths through search. Yet how to allocate a fixed rollout budget most effectively…

Machine Learning · Computer Science 2025-10-21 Xinglin Wang , Yiwei Li , Shaoxiong Feng , Peiwen Yuan , Yueqi Zhang , Jiayi Shi , Chuyi Tan , Boyuan Pan , Yao Hu , Kan Li

Recent advancements in Large Language Models (LLMs) have created new opportunities to enhance performance on complex reasoning tasks by leveraging test-time computation. However, existing scaling methods have key limitations: parallel…

Artificial Intelligence · Computer Science 2025-12-04 Jiefeng Chen , Jie Ren , Xinyun Chen , Chengrun Yang , Ruoxi Sun , Jinsung Yoon , Sercan Ö Arık
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