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The rapid worldwide spread of the severe acute respiratory syndrome (SARS) demonstrated the potential threat an infectious disease poses in a closely interconnected and interdependent world. Here we introduce a probabilistic model which…

Disordered Systems and Neural Networks · Physics 2009-11-10 L. Hufnagel , D. Brockmann , T. Geisel

Infectious diseases remain one of the major causes of human mortality and suffering. Mathematical models have been established as an important tool for capturing the features that drive the spread of the disease, predicting the progression…

The dynamics of contact networks and epidemics of infectious diseases often occur on comparable time scales. Ignoring one of these time scales may provide an incomplete understanding of the population dynamics of the infection process. We…

Populations and Evolution · Quantitative Biology 2021-02-09 Luis E C Rocha , Naoki Masuda

Characterizing sexual contact networks is essential for understanding sexually transmitted infections, but principled parameter inference for mechanistic network models remains challenging. We develop a discrete-time simulation framework…

Methodology · Statistics 2025-09-30 Till Hoffmann , Jukka-Pekka Onnela

We study contact epidemic models for the spread of infective diseases in finite populations. The size dependence enters in the infection rate. The dynamics of such models is then analyzed within the deterministic approximation, as well as…

Populations and Evolution · Quantitative Biology 2020-04-07 Ph. Blanchard , S. Nicolis

Effective intervention strategies for epidemics rely on the identification of their origin and on the robustness of the predictions made by network disease models. We introduce a Bayesian uncertainty quantification framework to infer model…

Populations and Evolution · Quantitative Biology 2020-04-02 Karen Larson , Clark Bowman , Zhizhong Chen , Panagiotis Hadjidoukas , Costas Papadimitriou , Petros Koumoutsakos , Anastasios Matzavinos

Mathematical models of infectious diseases, which are in principle analytically tractable, use two general approaches. The first approach, generally known as compartmental modeling, addresses the time evolution of disease propagation at the…

Populations and Evolution · Quantitative Biology 2010-09-16 Pierre-André Noël , Bahman Davoudi , Robert C. Brunham , Louis J. Dubé , Babak Pourbohloul

Ultrametric matrices are a class of covariance matrices that arise in latent tree models. As a parameter space in a statistical model, the set of ultrametric matrices is neither convex nor a smooth manifold. Focus in the literature has…

Methodology · Statistics 2025-04-28 Tsung-Hung Yao , Zhenke Wu , Karthik Bharath , Veerabhadran Baladandayuthapani

Human mobility, contact patterns, and their interplay are key aspects of our social behavior that shape the spread of infectious diseases across different regions. In the light of new evidence and data sets about these two elements,…

Physics and Society · Physics 2021-07-26 Wesley Cota , David Soriano-Paños , Alex Arenas , Silvio C. Ferreira , Jesús Gómez-Gardeñes

Motivated by examples from genetic association studies, this paper considers the model selection problem in a general complex linear model system and in a Bayesian framework. We discuss formulating model selection problems and incorporating…

Methodology · Statistics 2014-03-14 Xiaoquan Wen

Contact patterns in populations fundamentally influence the spread of infectious diseases. Current mathematical methods for epidemiological forecasting on networks largely assume that contacts between individuals are fixed, at least for the…

Populations and Evolution · Quantitative Biology 2007-05-23 Erik Volz , Lauren Ancel Meyers

The importance of modeling the spread of epidemics through a population has led to the development of mathematical models for infectious disease propagation. A number of empirical studies have collected and analyzed data on contacts between…

Social and Information Networks · Computer Science 2017-07-28 Rehan Ahmad , Kevin S. Xu

Synthetic contact networks are useful for modeling epidemic spread and social transmission, but data to infer realistic contact patterns that take account of assortative connections at the geographic and economic levels is limited. We…

Social and Information Networks · Computer Science 2024-06-24 Alexander Y. Tulchinsky , Fardad Haghpanah , Alisa Hamilton , Nodar Kipshidze , Eili Y. Klein

The study of infectious disease epidemiology for multi-type disease pathogens requires modelling techniques that account for the complex interactions existing between strains across geography and time. In this paper, we propose a novel…

Methodology · Statistics 2026-05-06 Matthew Adeoye , Simon E. F. Spencer , Xavier Didelot

Forecasting transmission of infectious diseases, especially for vector-borne diseases, poses unique challenges for researchers. Behaviors of and interactions between viruses, vectors, hosts, and the environment each play a part in…

Applications · Statistics 2020-06-02 Stephen A Lauer , Alexandria C Brown , Nicholas G Reich

Mathematical epidemiological models have a broad use, including both qualitative and quantitative applications. With the increasing availability of data, large-scale quantitative disease spread models can nowadays be formulated. Such models…

Methodology · Statistics 2021-08-10 Stefan Engblom , Robin Eriksson , Stefan Widgren

We study the impact of contact heterogeneity on epidemic dynamics. A system characterized by multiple susceptible populations is considered. The description of the spread of an infectious disease is obtained through the study of a system of…

Physics and Society · Physics 2021-11-11 Andrea Medaglia , Mattia Zanella

A susceptible-infected-susceptible (SIS) model of multiple contagions on multilayer networks is developed to incorporate different spreading channels and disease mutations. The basic reproduction number for this model is estimated…

Physics and Society · Physics 2020-03-31 Petar Jovanovski , Igor Tomovski , Ljupco Kocarev

When modeling the dynamics of infectious disease, the incorporation of contact network information allows for the capture of the non-randomness and heterogeneity of realistic contact patterns. Oftentimes, it is assumed that the underlying…

Populations and Evolution · Quantitative Biology 2024-04-17 Maxwell H. Wang , Jukka-Pekka Onnela

Social contact patterns are a key input to many infectious disease models. Contact surveys, where participants are asked to provide information on their recent close and casual contacts with others, are one of the standard methods to…

Populations and Evolution · Quantitative Biology 2025-11-07 Thomas J. Harris , Prescott C. Alexander , Anh B. D. Pham , Joseph Tuccillo , Nicholas Geard , Cameron Zachreson
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