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Single-photon lidar devices are able to collect an ever-increasing amount of time-stamped photons in small time periods due to increasingly larger arrays, generating a memory and computational bottleneck on the data processing side.…

Signal Processing · Electrical Eng. & Systems 2021-05-17 Michael P. Sheehan , Julián Tachella , Mike E. Davies

This thesis centres on the development of multidimensional fluorescence imaging tools, with a particular emphasis on fluorescence lifetime imaging (FLIM) microscopy for application to biological research. The key aspects of this thesis are…

Instrumentation and Detectors · Physics 2017-08-14 Egidijus Auksorius

This paper concerns an inverse problem for fluorescence diffuse optical tomography (FDOT) reconstructing locations of multiple point targets from the measured temporal response functions. The targets are multiple fluorescent point objects…

Numerical Analysis · Mathematics 2024-11-26 Shuli Chen , Junyong Eom , Gen Nakamura , Goro Nishimura

Diffraction imaging of non-equilibrium dynamics at atomic resolution is becoming possible with X-ray free-electron lasers. However, there are unresolved problems with applying this method to objects that are confined in only one dimension.…

Strongly Correlated Electrons · Physics 2018-02-19 Kenneth R. Beyerlein

We show that structural information can be extracted from single molecule localization microscopy (SMLM) data. More precisely, we reinterpret SMLM data as the measures of a phaseless optical diffraction tomography system for which the…

Signal Processing · Electrical Eng. & Systems 2023-07-19 Thanh-An Pham , Emmanuel Soubies , Ferréol Soulez , Michael Unser

Spectroscopy detected in the time domain entails many techniques, such as FTIR, pump-probe, FT-Raman, and 2DES, and applications, such as molecule characterization, excited state dynamics studies, or spectra classifications. Surprisingly,…

Optics · Physics 2024-05-21 Luca Bolzonello , Niek F van Hulst , Andreas Jakobsson

Multiview light sheet fluorescence microscopy (LSFM) allows to image developing organisms in 3D at unprecedented temporal resolution over long periods of time. The resulting massive amounts of raw image data requires extensive processing…

Quantitative Methods · Quantitative Biology 2015-08-12 Christopher Schmied , Peter Steinbach , Tobias Pietzsch , Stephan Preibisch , Pavel Tomancak

In this paper, we propose a novel dense surfel mapping system that scales well in different environments with only CPU computation. Using a sparse SLAM system to estimate camera poses, the proposed mapping system can fuse intensity images…

Robotics · Computer Science 2019-09-11 Kaixuan Wang , Fei Gao , Shaojie Shen

Modern high-throughput single-cell immune profiling technologies, such as flow and mass cytometry and single-cell RNA sequencing can readily measure the expression of a large number of protein or gene features across the millions of cells…

Quantitative Methods · Quantitative Biology 2022-07-05 Vishal Athreya Baskaran , Jolene Ranek , Siyuan Shan , Natalie Stanley , Junier B. Oliva

Scanning Transmission Electron Microscopy (STEM) has become the main stay for materials characterization on atomic level, with applications ranging from visualization of localized and extended defects to mapping order parameter fields. In…

Instrumentation and Detectors · Physics 2019-01-15 Xin Li , Ondrej Dyck , Sergei V. Kalinin , Stephen Jesse

Many optimally scaling quantum simulation algorithms employ controlled time evolution of the Hamiltonian, which is typically the major bottleneck for their efficient implementation. This work establishes a compression protocol for encoding…

Quantum Physics · Physics 2026-04-09 Erenay Karacan

Fluorescence lifetime imaging microscopy (FLIM) is a well-established technique with numerous imaging applications. Yet, one of the limitations of FLIM is that it provides information about the emitting state only. Here, we present an…

Biological Physics · Physics 2023-10-27 Pavel Malý , Dita Strachotová , Aleš Holoubek , Petr Heřman

With applications ranging from metabolomics to histopathology, quantitative phase microscopy (QPM) is a powerful label-free imaging modality. Despite significant advances in fast multiplexed imaging sensors and deep-learning-based inverse…

An alternative approach to ultrasound computed tomography (USCT) for medical imaging is proposed, with the intent to (i) shorten acquisition time for devices with a large number of emitters, (ii) eliminate the calibration step, and (iii)…

Medical Physics · Physics 2022-01-25 Ines Elisa Ulrich , Christian Boehm , Andrea Zunino , Cyrill Bösch , Andreas Fichtner

Efficiently selecting an appropriate spike stream data length to extract precise information is the key to the spike vision tasks. To address this issue, we propose a dynamic timing representation for spike streams. Based on multi-layers…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Lujie Xia , Ziluo Ding , Rui Zhao , Jiyuan Zhang , Lei Ma , Zhaofei Yu , Tiejun Huang , Ruiqin Xiong

In many laboratories, conventional bright-field transmission microscopes are available to study the structure and organization principles of fibrous tissue samples, but they usually provide only 2D information. To access the third…

Demands are increasing to measure per-flow statistics in the data plane of high-speed switches. Measuring flows with exact counting is infeasible due to processing and memory constraints, but a sketch is a promising candidate for collecting…

Networking and Internet Architecture · Computer Science 2021-11-05 SunYoung Kim , Changhun Jung , RhongHo Jang , David Mohaisen , DaeHun Nyang

Least-squares reverse time migration is well-known for its capability to generate artifact-free true-amplitude subsurface images through fitting observed data in the least-squares sense. However, when applied to realistic imaging problems,…

Geophysics · Physics 2020-03-04 Mengmeng Yang , Zhilong Fang , Philipp Witte , Felix J. Herrmann

Fluorescence Lifetime Imaging Microscopy in the time domain is typically performed by recording the arrival time of photons either by using electronic time tagging or a gated detector. As such the temporal resolution is limited by the…

Time series forecasting (TSF) is critical across domains such as finance, meteorology, and energy. While extending the lookback window theoretically provides richer historical context, in practice, it often introduces irrelevant noise and…

Machine Learning · Computer Science 2026-04-03 Xiang Ao , Yinyu Tan , Mengru Chen