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Related papers: BioResearcher: Scenario-Guided Multi-Agent for Tra…

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Conventional biomedical research is increasingly labor-intensive due to the exponential growth of scientific literature and datasets. Artificial intelligence (AI), particularly Large Language Models (LLMs), has the potential to…

Multiagent Systems · Computer Science 2025-07-08 Yi Luo , Linghang Shi , Yihao Li , Aobo Zhuang , Yeyun Gong , Ling Liu , Chen Lin

Frontier scientific reasoning is rapidly emerging as a key foundation for advancing AI agents in automated scientific discovery. Deep research agents offer a promising approach to this challenge. These models develop robust problem-solving…

Artificial Intelligence · Computer Science 2026-05-27 Tianshi Zheng , Rui Wang , Xiyun Li , Kelvin Kiu Wai Tam , Newt Nguyen Kim Hue Nam , Wei Fan , Yangqiu Song , Tianqing Fang

Agentic systems have recently emerged as a promising tool to automate literature-based ideation. However, current systems often remain black-box, with limited transparency or control for researchers. Our work introduces TrustResearcher, a…

Multiagent Systems · Computer Science 2026-01-27 Jiawei Zhou , Ruicheng Zhu , Mengshi Chen , Jianwei Wang , Kai Wang

We present M-Reason, a demonstration system for transparent, agent-based reasoning and evidence integration in the biomedical domain, with a focus on cancer research. M-Reason leverages recent advances in large language models (LLMs) and…

Artificial Intelligence · Computer Science 2025-10-08 Oskar Wysocki , Magdalena Wysocka , Mauricio Jacobo , Harriet Unsworth , André Freitas

Large Language Models (LLMs) and LLM-based agents show great promise in accelerating scientific research. Existing benchmarks for measuring this potential and guiding future development continue to evolve from pure recall and rote knowledge…

Recent developments in Large Language Model (LLM)-based agents have shown impressive capabilities spanning multiple domains, exemplified by deep research systems that demonstrate superior performance on complex information-seeking and…

Computation and Language · Computer Science 2025-09-03 Ailing Yu , Lan Yao , Jingnan Liu , Zhe Chen , Jiajun Yin , Yuan Wang , Xinhao Liao , Zhiling Ye , Ji Li , Yun Yue , Hansong Xiao , Hualei Zhou , Chunxiao Guo , Peng Wei , Junwei Liu , Jinjie Gu

Biomedical discovery often requires connecting broad biomedical knowledge with specific experimental or clinical data. Background knowledge suggests relevant mechanisms but is usually too general to map directly onto dataset variables,…

Artificial Intelligence · Computer Science 2026-05-27 Qingyuan Zeng , Ziyang Chen , Pengxiang Cai , Zixin Guan , Anglin Liu , Lang Qin , Xinyao Lai , Jintai Chen

Creating end-to-end bioinformatics workflows requires diverse domain expertise, which poses challenges for both junior and senior researchers as it demands a deep understanding of both genomics concepts and computational techniques. While…

Scientific research follows multi-turn, multi-step workflows that require proactively searching the literature, consulting figures and tables, and integrating evidence across papers to align experimental settings and support reproducible…

Computation and Language · Computer Science 2026-04-08 Xuan Dong , Huanyang Zheng , Tianhao Niu , Zhe Han , Pengzhan Li , Bofei Liu , Zhengyang Liu , Guancheng Li , Qingfu Zhu , Wanxiang Che

Emergency departments worldwide face rising patient volumes, workforce shortages, and variability in triage decisions that threaten the delivery of timely and accurate care. Current triage methods rely primarily on vital signs, routine…

Quantitative Methods · Quantitative Biology 2025-10-21 Kerem Delikoyun , Qianyu Chen , Win Sen Kuan , John Tshon Yit Soong , Matthew Edward Cove , Oliver Hayden

This paper introduces BioAgent Bench, a benchmark dataset and an evaluation suite designed for measuring the performance and robustness of AI agents in common bioinformatics tasks. The benchmark contains curated end-to-end tasks (e.g.,…

Artificial Intelligence · Computer Science 2026-05-08 Dionizije Fa , Marko Culjak , Bruno Pandza , Mateo Cupic

Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents. Tasks such as drug…

Artificial Intelligence · Computer Science 2025-12-15 Tim Cofala , Christian Kalfar , Jingge Xiao , Johanna Schrader , Michelle Tang , Wolfgang Nejdl

Rare diseases affect over 300 million individuals worldwide, yet timely and accurate diagnosis remains an urgent challenge. Patients often endure a prolonged diagnostic odyssey exceeding five years, marked by repeated referrals,…

Computation and Language · Computer Science 2026-02-17 Weike Zhao , Chaoyi Wu , Yanjie Fan , Xiaoman Zhang , Pengcheng Qiu , Yuze Sun , Xiao Zhou , Yanfeng Wang , Xin Sun , Ya Zhang , Yongguo Yu , Kun Sun , Weidi Xie

Agentic systems augment large language models with external tools and iterative decision making, enabling complex tasks such as deep research, function calling, and coding. However, their long and intricate execution traces make failure…

Recent advances in deep-research systems have demonstrated the potential for AI agents to autonomously discover and synthesize knowledge from external sources. In this paper, we introduce WebResearcher, a novel framework for building such…

Search intelligence is evolving from Deep Research to Wide Research, a paradigm essential for retrieving and synthesizing comprehensive information under complex constraints in parallel. However, progress in this field is impeded by the…

Computation and Language · Computer Science 2026-02-04 Ziyang Huang , Haolin Ren , Xiaowei Yuan , Jiawei Wang , Zhongtao Jiang , Kun Xu , Shizhu He , Jun Zhao , Kang Liu

Engineered image-based biomarkers offer a clinically interpretable alternative to black-box AI in computational pathology, yet their discovery remains largely intuition-driven, guided by fragmented literature rather than rigorous biological…

Precision therapeutics require multimodal adaptive models that generate personalized treatment recommendations. We introduce TxAgent, an AI agent that leverages multi-step reasoning and real-time biomedical knowledge retrieval across a…

Artificial Intelligence · Computer Science 2025-03-17 Shanghua Gao , Richard Zhu , Zhenglun Kong , Ayush Noori , Xiaorui Su , Curtis Ginder , Theodoros Tsiligkaridis , Marinka Zitnik

LLM agents are rapidly becoming the practical interface for task automation, yet the ecosystem lacks a principled way to choose among an exploding space of deployable configurations. Existing LLM leaderboards and tool/agent benchmarks…

Artificial Intelligence · Computer Science 2026-03-05 Yunxiao Shi , Wujiang Xu , Tingwei Chen , Haoning Shang , Ling Yang , Yunfeng Wan , Zhuo Cao , Xing Zi , Dimitris N. Metaxas , Min Xu

Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the…

Computation and Language · Computer Science 2024-07-23 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu
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