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The rapid growth of medical knowledge and increasing complexity of clinical practice pose challenges. In this context, large language models (LLMs) have demonstrated value; however, inherent limitations remain. Retrieval-augmented…

Purpose: To develop a retrieval-augmented generation (RAG) system powered by LLaMA-4 109B for automated, protocol-aware, and interpretable evaluation of radiotherapy treatment plans. Methods and Materials: We curated a multi-protocol…

Retrieval-Augmented Generation (RAG) has emerged as a critical technique for enhancing large language model (LLM) capabilities. However, practitioners face significant challenges when making RAG deployment decisions. While existing research…

Software Engineering · Computer Science 2025-07-22 Shengming Zhao , Yuchen Shao , Yuheng Huang , Jiayang Song , Zhijie Wang , Chengcheng Wan , Lei Ma

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

Retrieval-Augmented Generation (RAG) merges retrieval methods with deep learning advancements to address the static limitations of large language models (LLMs) by enabling the dynamic integration of up-to-date external information. This…

Information Retrieval · Computer Science 2026-05-19 Yizheng Huang , Jimmy Huang

Large Language Models (LLMs) have demonstrated significant potential in medical Question Answering (QA), yet they remain prone to hallucinations and ungrounded reasoning, limiting their reliability in high-stakes clinical scenarios. While…

Information Retrieval · Computer Science 2026-01-09 Jessica Ryan , Alexander I. Gumilang , Robert Wiliam , Derwin Suhartono

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

Retrieval-Augmented Generation (RAG) enables Large Language Models (LLMs) to extend their existing knowledge by dynamically incorporating external information. However, practical deployment is fundamentally constrained by the LLM's finite…

Information Retrieval · Computer Science 2026-03-24 Jiarui Guo , Yuemeng Xu , Zongwei Lv , Yangyujia Wang , Xiaolin Wang , Kan Liu , Tao Lan , Lin Qu , Tong Yang

Large language models achieve high task performance yet often hallucinate or rely on outdated knowledge. Retrieval-augmented generation (RAG) addresses these gaps by coupling generation with external search. We analyse how hyperparameters…

Machine Learning · Computer Science 2025-05-14 Adel Ammar , Anis Koubaa , Omer Nacar , Wadii Boulila

Recent advancements in retrieval-augmented generation (RAG) have significantly enhanced the ability of large language models (LLMs) to perform complex question-answering (QA) tasks. In this paper, we introduce MedBioRAG, a…

Computation and Language · Computer Science 2025-12-15 Seonok Kim

Objective: To optimize in-context learning in biomedical natural language processing by improving example selection. Methods: We introduce a novel multi-mode retrieval-augmented generation (MMRAG) framework, which integrates four retrieval…

Computation and Language · Computer Science 2025-02-25 Zaifu Zhan , Jun Wang , Shuang Zhou , Jiawen Deng , Rui Zhang

Recent advancements in Retrieval-Augmented Generation (RAG) have enabled Large Language Models to answer financial questions using external knowledge bases of U.S. SEC filings, earnings reports, and regulatory documents. However, existing…

Retrieval-Augmented Generation (RAG) systems for biomedical literature are typically evaluated using ranking metrics like Mean Reciprocal Rank (MRR), which measure how well the system identifies the single most relevant chunk. We argue that…

Artificial Intelligence · Computer Science 2026-03-25 Pouria Mortezaagha , Arya Rahgozar

We propose a simple, unsupervised method that injects pragmatic principles in retrieval-augmented generation (RAG) frameworks such as Dense Passage Retrieval to enhance the utility of retrieved contexts. Our approach first identifies which…

Computation and Language · Computer Science 2025-02-28 Haris Riaz , Ellen Riloff , Mihai Surdeanu

Retrieval-augmented generation (RAG) improves large language model reliability by grounding generated responses in external evidence. However, RAG performance depends on the relevance of retrieved passages, the quality of evidence ranking,…

Information Retrieval · Computer Science 2026-05-05 Fariba Afrin Irany , Sampson Akwafuo

Retrieval-Augmented Generation (RAG) struggles with domain-specific enterprise datasets, often isolated behind firewalls and rich in complex, specialized terminology unseen by LLMs during pre-training. Semantic variability across domains…

Computation and Language · Computer Science 2025-08-06 Kunal Sawarkar , Shivam R. Solanki , Abhilasha Mangal

Retrieval-Augmented Generation (RAG) systems have recently shown remarkable advancements by integrating retrieval mechanisms into language models, enhancing their ability to produce more accurate and contextually relevant responses.…

Computation and Language · Computer Science 2025-01-14 Siran Li , Linus Stenzel , Carsten Eickhoff , Seyed Ali Bahrainian

Retrieval-Augmented Generation (RAG) significantly improves the factuality of Large Language Models (LLMs), yet standard pipelines often lack mechanisms to verify inter- mediate reasoning, leaving them vulnerable to hallucinations in…

Computation and Language · Computer Science 2026-03-12 Eeham Khan , Luis Rodriguez , Marc Queudot

Agentic Retrieval Augmented Generation (RAG) and 'deep research' systems aim to enable autonomous search processes where Large Language Models (LLMs) iteratively refine outputs. However, applying these systems to domain-specific…

Computation and Language · Computer Science 2025-08-08 Samy Ateia , Udo Kruschwitz

Retrieval-Augmented Generation (RAG) has emerged as a powerful paradigm to enhance large language models (LLMs) by conditioning generation on external evidence retrieved at inference time. While RAG addresses critical limitations of…

Information Retrieval · Computer Science 2025-06-03 Chaitanya Sharma