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Large language models (LLMs) have demonstrated strong capabilities in medical question answering; however, purely parametric models often suffer from knowledge gaps and limited factual grounding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2026-04-09 Nusrat Sultana , Abdullah Muhammad Moosa , Kazi Afzalur Rahman , Sajal Chandra Banik

Retrieval-Augmented Generation (RAG) systems critically depend on retrieval quality, yet no systematic comparison of modern retrieval methods exists for heterogeneous documents containing both text and tabular data. We benchmark ten…

Information Retrieval · Computer Science 2026-04-03 Meftun Akarsu , Recep Kaan Karaman , Christopher Mierbach

Biomedical question-answering (QA) systems require effective retrieval and generation components to ensure accuracy, efficiency, and scalability. This study systematically examines a Retrieval-Augmented Generation (RAG) system for…

Information Retrieval · Computer Science 2026-01-14 Linus Stuhlmann , Michael Alexander Saxer , Jonathan Fürst

The rapidly growth of biomedical literature creates challenges acquiring specific medical information. Current biomedical question-answering systems primarily focus on short-form answers, failing to provide comprehensive explanations…

Computation and Language · Computer Science 2026-01-05 Lovely Yeswanth Panchumarthi , Sumalatha Saleti , Sai Prasad Gudari , Atharva Negi , Praveen Raj Budime , Harsit Upadhya

Retrieval-Augmented Generation (RAG) is a prevalent approach to infuse a private knowledge base of documents with Large Language Models (LLM) to build Generative Q\&A (Question-Answering) systems. However, RAG accuracy becomes increasingly…

Information Retrieval · Computer Science 2025-03-10 Kunal Sawarkar , Abhilasha Mangal , Shivam Raj Solanki

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical…

Computation and Language · Computer Science 2026-02-12 Liz Li , Wei Zhu

A Comparison of Independent and Joint Fine-tuning Strategies for Retrieval-Augmented Generation Download PDF Neal Gregory Lawton, Alfy Samuel, Anoop Kumar, Daben Liu Published: 20 Aug 2025, Retrieval augmented generation (RAG) is a popular…

Computation and Language · Computer Science 2025-10-21 Neal Gregory Lawton , Alfy Samuel , Anoop Kumar , Daben Liu

While large language models (LLMs) have achieved state-of-the-art performance on a wide range of medical question answering (QA) tasks, they still face challenges with hallucinations and outdated knowledge. Retrieval-augmented generation…

Computation and Language · Computer Science 2024-02-26 Guangzhi Xiong , Qiao Jin , Zhiyong Lu , Aidong Zhang

Biomedical semantic question answering rooted in information retrieval can play a crucial role in keeping up to date with vast, rapidly evolving and ever-growing biomedical literature. A robust system can help researchers, healthcare…

Information Retrieval · Computer Science 2025-07-09 Shashank Verma , Fengyi Jiang , Xiangning Xue

Retrieval-augmented generation (RAG) has emerged as a promising approach to enhance the performance of large language models (LLMs) in knowledge-intensive tasks such as those from medical domain. However, the sensitive nature of the medical…

Computation and Language · Computer Science 2024-11-15 Nghia Trung Ngo , Chien Van Nguyen , Franck Dernoncourt , Thien Huu Nguyen

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models…

Retrieval-Augmented Generation (RAG) is a powerful technique for enriching Large Language Models (LLMs) with external knowledge, allowing for factually grounded responses, a critical requirement in high-stakes domains such as healthcare.…

Computation and Language · Computer Science 2025-10-07 Eduardo Martínez Rivera , Filippo Menolascina

Retrieval-augmented generation (RAG) is a common way to ground language models in external documents and up-to-date information. Classical retrieval systems relied on lexical methods such as BM25, which rank documents by term overlap with…

Computation and Language · Computer Science 2026-03-05 Martin Asenov , Kenza Benkirane , Dan Goldwater , Aneiss Ghodsi

Given the growing trend of many organizations integrating Retrieval Augmented Generation (RAG) into their operations, we assess RAG on domain-specific data and test state-of-the-art models across various optimization techniques. We…

Artificial Intelligence · Computer Science 2024-11-14 Anum Afzal , Juraj Vladika , Gentrit Fazlija , Andrei Staradubets , Florian Matthes

Retrieval-augmented generation (RAG) has emerged as an approach to augment large language models (LLMs) by reducing their reliance on static knowledge and improving answer factuality. RAG retrieves relevant context snippets and generates an…

Computation and Language · Computer Science 2025-02-21 Juraj Vladika , Florian Matthes

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Organizations increasingly rely on proprietary enterprise data, including HR records, structured reports, and tabular documents, for critical decision-making. While Large Language Models (LLMs) have strong generative capabilities, they are…

Computation and Language · Computer Science 2025-07-17 Chandana Cheerla

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Medical retrieval-augmented generation (RAG) systems typically operate on text chunks extracted from biomedical literature, discarding the rich visual content (tables, figures, structured layouts) of original document pages. We propose…

Artificial Intelligence · Computer Science 2026-05-01 Xupeng Chen , Binbin Shi , Chenqian Le , Jiaqi Zhang , Kewen Wang , Ran Gong , Jinhan Zhang , Chihang Wang

This systematic review of the research literature on retrieval-augmented generation (RAG) provides a focused analysis of the most highly cited studies published between 2020 and May 2025. A total of 128 articles met our inclusion criteria.…

Digital Libraries · Computer Science 2025-09-10 Andrew Brown , Muhammad Roman , Barry Devereux
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