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Causal indirect and direct effects provide an interpretable method for decomposing the total effect of an exposure on an outcome into the effect through a mediator and the effect through all other pathways. When the mediator is a biomarker,…

Methodology · Statistics 2021-08-02 Ariel Chernofsky , Ronald J. Bosch , Judith J. Lok

Continuous Conditional Generative Modeling (CCGM) estimates high-dimensional data distributions, such as images, conditioned on scalar continuous variables (aka regression labels). While Continuous Conditional Generative Adversarial…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Xin Ding , Yongwei Wang , Kao Zhang , Z. Jane Wang

We consider the problem of identifying intermediate variables (or mediators) that regulate the effect of a treatment on a response variable. While there has been significant research on this classical topic, little work has been done when…

Methodology · Statistics 2021-07-29 Abhishek Chakrabortty , Preetam Nandy , Hongzhe Li

Diffusion models (DMs) are a type of generative model that has a huge impact on image synthesis and beyond. They achieve state-of-the-art generation results in various generative tasks. A great diversity of conditioning inputs, such as text…

Machine Learning · Computer Science 2024-02-02 Weiguo Lu , Xuan Wu , Deng Ding , Jinqiao Duan , Jirong Zhuang , Gangnan Yuan

Predictive modeling uncovers knowledge and insights regarding a hypothesized data generating mechanism (DGM). Results from different studies on a complex DGM, derived from different data sets, and using complicated models and algorithms,…

Methodology · Statistics 2022-11-21 Anna L. Smith , Tian Zheng , Andrew Gelman

Aleatoric uncertainty quantification seeks for distributional knowledge of random responses, which is important for reliability analysis and robustness improvement in machine learning applications. Previous research on aleatoric uncertainty…

Machine Learning · Computer Science 2022-06-10 Ziyi Huang , Henry Lam , Haofeng Zhang

Practitioners in diverse fields such as healthcare, economics and education are eager to apply machine learning to improve decision making. The cost and impracticality of performing experiments and a recent monumental increase in electronic…

Machine Learning · Computer Science 2023-08-01 Fredrik D. Johansson , Uri Shalit , Nathan Kallus , David Sontag

Climate change is intensifying rainfall extremes, making high-resolution precipitation projections crucial for society to better prepare for impacts such as flooding. However, current Global Climate Models (GCMs) operate at spatial…

Machine Learning · Computer Science 2024-12-20 Ran Lyu , Linhan Wang , Yanshen Sun , Hedanqiu Bai , Chang-Tien Lu

This paper proposes an efficient approach to learning disentangled representations with causal mechanisms based on the difference of conditional probabilities in original and new distributions. We approximate the difference with models'…

Machine Learning · Computer Science 2024-01-03 Yuanpeng Li , Joel Hestness , Mohamed Elhoseiny , Liang Zhao , Kenneth Church

Multimodal learning integrates diverse modalities but suffers from modality imbalance, where dominant modalities suppress weaker ones due to inconsistent convergence rates. Existing methods predominantly rely on static modulation or…

Machine Learning · Computer Science 2026-02-11 Zhaocheng Liu , Zhiwen Yu , Xiaoqing Liu

Accurate estimation of counterfactual outcomes in high-dimensional data is crucial for decision-making and understanding causal relationships and intervention outcomes in various domains, including healthcare, economics, and social…

Machine Learning · Computer Science 2024-07-31 Jiageng Zhu , Hanchen Xie , Jiazhi Li , Wael Abd-Almageed

Discrete diffusion models (DDMs) are a powerful class of generative models for categorical data, but they typically require many function evaluations for a single sample, making inference expensive. Existing acceleration methods either rely…

Machine Learning · Computer Science 2025-12-16 Yansong Gao , Yu Sun

We propose a difference-in-differences (DiD) framework with mediation for possibly multivalued discrete or continuous treatments and mediators, aimed at identifying the direct effect of the treatment on the outcome (net of effects operating…

Econometrics · Economics 2026-03-02 Martin Huber , Sarina Joy Oberhänsli

Method validation and study design in causal inference rely on synthetic data with known counterfactuals. Existing simulators trade off distributional realism, the ability to capture mixed-type and multimodal tabular data, against causal…

Methodology · Statistics 2026-03-05 Qi Zhang , Harsh Parikh , Ashley Naimi , Razieh Nabi , Christopher Kim , Timothy Lash

The success of large generative models has driven a paradigm shift, leveraging massive multi-source data to enhance model capabilities. However, the interaction among these sources remains theoretically underexplored. This paper takes the…

Machine Learning · Computer Science 2025-07-09 Rongzhen Wang , Yan Zhang , Chenyu Zheng , Chongxuan Li , Guoqiang Wu

In real-world scenarios, datasets collected from randomized experiments are often constrained by size, due to limitations in time and budget. As a result, leveraging large observational datasets becomes a more attractive option for…

Machine Learning · Statistics 2024-03-19 Danyang Wang , Chengchun Shi , Shikai Luo , Will Wei Sun

We propose a deep generative approach to sampling from a conditional distribution based on a unified formulation of conditional distribution and generalized nonparametric regression function using the noise-outsourcing lemma. The proposed…

Statistics Theory · Mathematics 2021-10-22 Xingyu Zhou , Yuling Jiao , Jin Liu , Jian Huang

We discuss causal mediation analyses for survival data and propose a new approach based on the additive hazards model. The emphasis is on a dynamic point of view, that is, understanding how the direct and indirect effects develop over time.…

Predicting potential outcomes of interventions from observational data is crucial for decision-making in medicine, but the task is challenging due to the fundamental problem of causal inference. Existing methods are largely limited to point…

Machine Learning · Computer Science 2024-10-14 Yuchen Ma , Valentyn Melnychuk , Jonas Schweisthal , Stefan Feuerriegel

We introduce a framework for learning robust visual representations that generalize to new viewpoints, backgrounds, and scene contexts. Discriminative models often learn naturally occurring spurious correlations, which cause them to fail on…

Computer Vision and Pattern Recognition · Computer Science 2021-03-30 Chengzhi Mao , Augustine Cha , Amogh Gupta , Hao Wang , Junfeng Yang , Carl Vondrick