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At the cellular scale, biochemical processes are governed by random interactions between reactant molecules with small copy counts, leading to behavior that is inherently stochastic. Such systems are often modeled as continuous-time Markov…

Data Structures and Algorithms · Computer Science 2015-09-02 Kevin R. Sanft , Hans G. Othmer

Simulated annealing (SA) is a well-known algorithm for solving combinatorial optimization problems. However, the computation time of SA increases rapidly, as the size of the problem grows. Recently, a stochastic simulated annealing (SSA)…

Hardware Architecture · Computer Science 2026-01-27 Duckgyu Shin , Naoya Onizawa , Warren J. Gross , Takahiro Hanyu

Due to the limited number of bits in floating-point or fixed-point arithmetic, rounding is a necessary step in many computations. Although rounding methods can be tailored for different applications, round-off errors are generally…

Numerical Analysis · Mathematics 2020-06-02 Lu Xia , Martijn Anthonissen , Michiel Hochstenbach , Barry Koren

Comprehensive simulations of the entire biochemistry of cells have great potential to help physicians treat disease and help engineers design biological machines. But such simulations must model networks of millions of molecular species and…

Molecular Networks · Quantitative Biology 2020-05-22 Arthur P. Goldberg , David R. Jefferson , John A. P. Sekar , Jonathan R. Karr

Large-scale numerical computations make increasing use of low-precision (LP) floating point formats and mixed precision arithmetic, which can be enhanced by the technique of stochastic rounding (SR), that is, rounding an intermediate…

Numerical Analysis · Mathematics 2025-04-30 Andrew Fitzgibbon , Stephen Felix

Classical probabilistic rounding error analysis is particularly well suited to stochastic rounding (SR), and it yields strong results when dealing with floating-point algorithms that rely heavily on summation. For many numerical linear…

Numerical Analysis · Mathematics 2025-02-26 El-Mehdi El Arar , Massimiliano Fasi , Silviu-Ioan Filip , Mantas Mikaitis

Modern computer architectures support low-precision arithmetic, which present opportunities for the adoption of mixed-precision algorithms to achieve high computational throughput and reduce energy consumption. As a growing number of…

Computation · Statistics 2024-12-02 Sahil Bhola , Karthik Duraisamy

Stochastic rounding (SR) is a probabilistic method used to round numbers to floating-point and fixed-point representations. In length $n$ summation, the worst-case error of SR grows as $\sqrt{n}$ with high probability, unlike for standard…

Numerical Analysis · Mathematics 2026-03-09 El-Mehdi El Arar , Massimiliano Fasi , Silviu-Ioan Filip , Mantas Mikaitis

In this paper, we evaluate stochastic-computing simulated annealing (SC-SA) for solving large-scale combinatorial optimization problems. SC-SA is designed using stochastic computing, where the computatoin is reazlied using random bitstream,…

Optimization and Control · Mathematics 2026-03-24 Kota Katsuki , Duckgyu Shin , Naoya Onizawa , Takahiro Hanyu

Traditional optimization methods rely on the use of single-precision floating point arithmetic, which can be costly in terms of memory size and computing power. However, mixed precision optimization techniques leverage the use of both…

Machine Learning · Computer Science 2023-09-25 Basile Lewandowski , Atli Kosson

Stochastic approximation (SA) is a powerful and scalable computational method for iteratively estimating the solution of optimization problems in the presence of randomness, particularly well-suited for large-scale and streaming data…

Statistics Theory · Mathematics 2023-10-03 Meimei Liu , Zuofeng Shang , Yun Yang

In recent years, several particle-based stochastic simulation algorithms (PSSA) have been developed to study the spatially resolved dynamics of biochemical networks at a molecular scale. A challenge all these approaches have to address is…

Quantitative Methods · Quantitative Biology 2011-07-04 Thorsten Prüstel , Martin Meier-Schellersheim

Stochastic rounding (SR) is a probabilistic rounding mode that mitigates errors in large-scale numerical computations, especially when prone to stagnation effects. Beyond numerical analysis, SR has shown significant benefits in practical…

Numerical Analysis · Mathematics 2026-03-26 El-Mehdi El Arar , Massimiliano Fasi , Silviu-Ioan Filip , Mantas Mikaitis

Stochastic approximation (SA) that involves multiple coupled sequences, known as multiple-sequence SA (MSSA), finds diverse applications in the fields of signal processing and machine learning. However, existing theoretical understandings…

Machine Learning · Computer Science 2024-10-18 Yue Huang , Zhaoxian Wu , Shiqian Ma , Qing Ling

The stochastic simulation of large-scale biochemical reaction networks is of great importance for systems biology since it enables the study of inherently stochastic biological mechanisms at the whole cell scale. Stochastic Simulation…

Molecular Networks · Quantitative Biology 2017-10-30 Elias S. Manolakos , Elias Kouskoumvekakis

Stochastic approximation (SA) algorithms have been widely applied in minimization problems when the loss functions and/or the gradient information are only accessible through noisy evaluations. Stochastic gradient (SG) descent---a…

Optimization and Control · Mathematics 2019-08-26 Jingyi Zhu , Long Wang , James C. Spall

Training Deep Neural Networks (DNNs) can be computationally demanding, particularly when dealing with large models. Recent work has aimed to mitigate this computational challenge by introducing 8-bit floating-point (FP8) formats for…

Hardware Architecture · Computer Science 2024-09-27 Sami Ben Ali , Silviu-Ioan Filip , Olivier Sentieys

The use of reduced and mixed precision computing has gained increasing attention in high-performance computing (HPC) as a means to improve computational efficiency, particularly on modern hardware architectures like GPUs. In this work, we…

Computational Engineering, Finance, and Science · Computer Science 2025-05-28 Bálint Siklósi , Pushpender K. Sharma , David J. Lusher , István Z. Reguly , Neil D. Sandham

Variance reduction has been commonly used in stochastic optimization. It relies crucially on the assumption that the data set is finite. However, when the data are imputed with random noise as in data augmentation, the perturbed data set…

Machine Learning · Computer Science 2018-06-11 Shuai Zheng , James T. Kwok

We consider the problem of efficiently simulating stochastic models of chemical kinetics. The Gillespie Stochastic Simulation algorithm (SSA) is often used to simulate these models, however, in many scenarios of interest, the computational…

Molecular Networks · Quantitative Biology 2024-07-10 Thomas Trigo Trindade , Konstantinos C. Zygalakis
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