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Turing patterns are a central paradigm for describing spatial patterns in nature. The corresponding theory of reaction-diffusion dynamics combines ideal diffusion with nonlinear reactions, resulting in patterns when species diffuse at…

Biological Physics · Physics 2026-01-28 Cathelijne ter Burg , David Zwicker

Modern materials are often synthesized or operated in complex chemical environments, where there can be numerous elemental species, competing phases, and reaction pathways. When analyzing reactions using the Gibbs free energy, which has a…

Materials Science · Physics 2024-04-10 Jiadong Chen , Matthew J. Powell-Palm , Wenhao Sun

Rule-based modelling allows to represent molecular interactions in a compact and natural way. The underlying molecular dynamics, by the laws of stochastic chemical kinetics, behaves as a continuous-time Markov chain. However, this Markov…

Other Computer Science · Computer Science 2018-12-27 Tatjana Petrov

Much of the theory on chemical-reaction networks (CRNs) has been developed in the ideal-solution limit, where interactions between the solutes are negligible. However, there is a large variety of phenomena in biological cells and…

Biological Physics · Physics 2022-12-09 Ander Movilla Miangolarra , Michele Castellana

Phase separation drives the formation of biomolecular condensates in cells, which comprise many components and sometimes possess multiple phases. The equilibrium physics of phase separation is well understood, but many components in…

Soft Condensed Matter · Physics 2025-08-14 Yicheng Qiang , Chengjie Luo , David Zwicker

Equations of motion that recognize biochemical patterns are described. The equations are partial differential equations in a continuous multiple component system in which adequate initial and boundary conditions are given. The biochemical…

Biological Physics · Physics 2010-03-25 Eisuke Chikayama

In a companion paper, we put forth a thermodynamic model for complex formation via a chemical reaction involving multiple macromolecular species, which may subsequently undergo liquid-liquid phase separation and a further transition into a…

Biological Physics · Physics 2024-07-26 Ruoyao Zhang , Sheng Mao , Mikko P. Haataja

Multicomponent systems are ubiquitous in nature and industry. While the physics of few-component liquid mixtures (i.e., binary and ternary ones) is well-understood and routinely taught in undergraduate courses, the thermodynamic and kinetic…

Soft Condensed Matter · Physics 2019-10-07 Sheng Mao , Derek Kuldinow , Mikko P. Haataja , Andrej Kosmrlj

For different phases to coexist in equilibrium at constant temperature $T$ and pressure $P$, the condition of equal chemical potential $\mu$ must be satisfied. This condition dictates that, for a single-component system, the maximum number…

Soft Condensed Matter · Physics 2016-11-23 Kenji Akahane , John Russo , Hajime Tanaka

A class of systems is considered, where immobile species associated to distinct patches, the nodes of a network, interact both locally and at a long-range, as specified by an (interaction) adjacency matrix. Non local interactions are…

Pattern Formation and Solitons · Physics 2020-06-30 Giulia Cencetti , Federico Battiston , Timoteo Carletti , Duccio Fanelli

Collectives of actively-moving particles can spontaneously segregate into dilute and dense phases through a process known as motility-induced phase separation (MIPS). This captivating phenomenon is well-studied for randomly-moving particles…

Soft Condensed Matter · Physics 2026-03-04 Hongbo Zhao , Qiwei Yu , Andrej Košmrlj , Sujit S. Datta

Linear conjugacy offers a new perspective to broaden the scope of stable biochemical reaction networks to the systems linearly conjugated to the well-established complex balanced mass action systems ($\ell$cCBMASs). This paper addresses the…

Dynamical Systems · Mathematics 2024-05-27 Xiaoyu Zhang , Shibo He , Chuanhou Gao , Denis Dochain

We demonstrate that active rotations in chemically signalling particles, such as autochemotactic {\it E. coli} close to walls, create a route for pattern formation based on a nonlinear yet deterministic instability mechanism. For slow…

Soft Condensed Matter · Physics 2016-08-19 Benno Liebchen , Michael E. Cates , Davide Marenduzzo

We consider a phase field crystal modeling approach for binary mixtures of interacting active and passive particles. The approach allows to describe generic properties for such systems within a continuum model. We validate the approach by…

Soft Condensed Matter · Physics 2018-09-19 Francesco Alaimo , Axel Voigt

We establish the criterion for the phase coexistence in a mixture of nonreciprocally interacting scalar densities. For an arbitrary number of components the active pressure exists for a specific class of interactions, and when the free…

Soft Condensed Matter · Physics 2024-02-16 Suropriya Saha

In living cells, chemical reactions form a complex network. Complicated dynamics arising from such networks are the origins of biological functions. We propose a novel mathematical method to analyze bifurcation behaviors of a reaction…

Molecular Networks · Quantitative Biology 2018-08-08 Takashi Okada , Je-Chiang Tsai , Atsushi Mochizuki

Theoretical work has shed light on the phase behavior of idealized mixtures of many components with random interactions. But typical mixtures interact through particular physical features, leading to a structured, non-random interaction…

Statistical Mechanics · Physics 2022-09-05 Isabella R. Graf , Benjamin B. Machta

Self-organized emergent patterns can be widely seen in particle interactions producing complex structures such as chemical elements and molecules. Inspired by these interactions, this work presents a novel stochastic approach that allows a…

Robotics · Computer Science 2022-09-01 Paulo Rezeck , Luiz Chaimowicz

Phase separation has emerged as an essential concept for the spatial organization inside biological cells. However, despite the clear relevance to virtually all physiological functions, we understand surprisingly little about what phases…

Biological Physics · Physics 2022-08-10 David Zwicker , Liedewij Laan

Mixtures of several macromolecular species can lead to the formation of higher-order structures that often display non-ideal mixing behavior. In this work, we propose a minimal model of a quaternary system which considers the formation of a…

Soft Condensed Matter · Physics 2022-12-14 Ruoyao Zhang , Sheng Mao , Mikko Haataja