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Leveraging high-quality joint representations from multimodal data can greatly enhance model performance in various machine-learning based applications. Recent multimodal learning methods, based on the multimodal information bottleneck…

Machine Learning · Computer Science 2025-05-27 Qilong Wu , Yiyang Shao , Jun Wang , Xiaobo Sun

Dynamical systems in the life sciences are often composed of complex mixtures of overlapping behavioral regimes. Cellular subpopulations may shift from cycling to equilibrium dynamics or branch towards different developmental fates. The…

Machine Learning · Computer Science 2025-10-13 Nathan Quiblier , Roy Friedman , Matthew Ricci

Learning multimodal representations is a fundamentally complex research problem due to the presence of multiple heterogeneous sources of information. Although the presence of multiple modalities provides additional valuable information,…

Machine Learning · Computer Science 2019-05-15 Yao-Hung Hubert Tsai , Paul Pu Liang , Amir Zadeh , Louis-Philippe Morency , Ruslan Salakhutdinov

Visual imitation learning (VIL) provides an efficient and intuitive strategy for robotic systems to acquire novel skills. Recent advancements in foundation models, particularly Vision Language Models (VLMs), have demonstrated remarkable…

Robotics · Computer Science 2025-07-29 Guangyan Chen , Meiling Wang , Te Cui , Yao Mu , Haoyang Lu , Zicai Peng , Mengxiao Hu , Tianxing Zhou , Mengyin Fu , Yi Yang , Yufeng Yue

Time series data are valuable but are often inscrutable. Gaining trust in time series classifiers for finance, healthcare, and other critical applications may rely on creating interpretable models. Researchers have previously been forced to…

Machine Learning · Computer Science 2021-11-09 Yuhui Wang , Diane J. Cook

Molecular knowledge resides within three different modalities of information sources: molecular structures, biomedical documents, and knowledge bases. Effective incorporation of molecular knowledge from these modalities holds paramount…

Biomolecules · Quantitative Biology 2023-07-24 Yizhen Luo , Kai Yang , Massimo Hong , Xing Yi Liu , Zaiqing Nie

Unlocking deep and interpretable biological reasoning from complex genomic data remains a major AI challenge limiting scientific progress. While current DNA foundation models excel at representing sequences, they struggle with multi-step…

Interpreting transcriptomic data is one of the most common analytical tasks in modern biology. Yet most current models either consume expression profiles without producing natural-language biological explanations, or reason in language…

Understanding how chemical perturbations propagate through biological systems is essential for robust molecular property prediction. While most existing methods focus on chemical structures alone, recent advances highlight the crucial role…

Machine Learning · Computer Science 2025-11-27 Mengran Li , Zelin Zang , Wenbin Xing , Junzhou Chen , Ronghui Zhang , Jiebo Luo , Stan Z. Li

Building multisensory AI systems that learn from multiple sensory inputs such as text, speech, video, real-world sensors, wearable devices, and medical data holds great promise for impact in many scientific areas with practical benefits,…

Machine Learning · Computer Science 2024-05-01 Paul Pu Liang

Recent advances in large language models (LLMs) have enabled multimodal foundation models to tackle both image understanding and generation within a unified framework. Despite these gains, unified models often underperform compared to…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Zhiyang Xu , Jiuhai Chen , Zhaojiang Lin , Xichen Pan , Lifu Huang , Tianyi Zhou , Madian Khabsa , Qifan Wang , Di Jin , Michihiro Yasunaga , Lili Yu , Xi Victoria Lin , Shaoliang Nie

Multimodal machine learning, mimicking the human brain's ability to integrate various modalities has seen rapid growth. Most previous multimodal models are trained on perfectly paired multimodal input to reach optimal performance. In…

Machine Learning · Computer Science 2026-02-06 Ronghao Lin , Qiaolin He , Sijie Mai , Ying Zeng , Aolin Xiong , Li Huang , Yap-Peng Tan , Haifeng Hu

Human cognition is profoundly shaped by the environments in which it unfolds. Yet, it remains an open question whether learning and decision making can be explained as a principled adaptation to the statistical structure of real-world…

Neurons and Cognition · Quantitative Biology 2025-09-04 Akshay K. Jagadish , Mirko Thalmann , Julian Coda-Forno , Marcel Binz , Eric Schulz

Large language models (LLMs) have shown remarkable capabilities in general domains, but their application to multi-omics biology remains underexplored. To address this gap, we introduce Biology-Instructions, the first large-scale…

We present a foundation model for brain MRI that can work with different combinations of imaging sequences. The model uses one encoder with learnable modality embeddings, conditional layer normalization, and a masked autoencoding objective…

Computer Vision and Pattern Recognition · Computer Science 2025-11-06 Minh Sao Khue Luu , Bair N. Tuchinov

Current generative models for drug discovery primarily use molecular docking to evaluate the quality of generated compounds. However, such models are often not useful in practice because even compounds with high docking scores do not…

Biomolecules · Quantitative Biology 2024-02-19 Peter Eckmann , Dongxia Wu , Germano Heinzelmann , Michael K Gilson , Rose Yu

A person's demonstration often serves as a key reference for others learning the same task. However, RGB video, the dominant medium for representing these demonstrations, often fails to capture fine-grained contextual cues such as intent,…

Computer Vision and Pattern Recognition · Computer Science 2025-05-06 Gabriel Sarch , Balasaravanan Thoravi Kumaravel , Sahithya Ravi , Vibhav Vineet , Andrew D. Wilson

Goal-directed molecular generation requires satisfying heterogeneous constraints such as protein--ligand compatibility and multi-objective drug-like properties, yet existing methods often optimize these constraints in isolation, failing to…

Machine Learning · Computer Science 2026-04-14 Yanting Li , Zhuoyang Jiang , Enyan Dai , Lei Wang , Wen-Cai Ye , Li Liu

Reliable medical image classification requires accurate predictions and well-calibrated uncertainty estimates, especially in high-stakes clinical settings. This work presents MedSymmFlow, a generative-discriminative hybrid model built on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Francisco Caetano , Lemar Abdi , Christiaan Viviers , Amaan Valiuddin , Fons van der Sommen

Chemical reactions are the fundamental building blocks of drug design and organic chemistry research. In recent years, there has been a growing need for a large-scale deep-learning framework that can efficiently capture the basic rules of…

Machine Learning · Computer Science 2024-03-08 Bo Qiang , Yiran Zhou , Yuheng Ding , Ningfeng Liu , Song Song , Liangren Zhang , Bo Huang , Zhenming Liu