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Large language models (LLMs) have recently showcased remarkable capabilities, spanning a wide range of tasks and applications, including those in the medical domain. Models like GPT-4 excel in medical question answering but may face…

Computation and Language · Computer Science 2025-07-02 Bowen Wang , Jiuyang Chang , Yiming Qian , Guoxin Chen , Junhao Chen , Zhouqiang Jiang , Jiahao Zhang , Yuta Nakashima , Hajime Nagahara

As Large Language Models are increasingly deployed in high-stakes domains, their ability to detect false assumptions and reason critically is crucial for ensuring reliable outputs. False-premise questions (FPQs) serve as an important…

Computation and Language · Computer Science 2025-06-05 Mohammadamin Shafiei , Hamidreza Saffari , Nafise Sadat Moosavi

Multimodal large language models (MLLMs) have shown great potential in medical applications, yet existing benchmarks inadequately capture real-world clinical complexity. We introduce MEDSYN, a multilingual, multimodal benchmark of highly…

Computation and Language · Computer Science 2026-04-20 Boqi Chen , Xudong Liu , Jiachuan Peng , Marianne Frey-Marti , Bang Zheng , Kyle Lam , Lin Li , Jianing Qiu

Multimodal Large Language Models (MLLMs) in healthcare suffer from severe confirmation bias, often hallucinating visual details to support initial, potentially erroneous diagnostic hypotheses. Existing Chain-of-Thought (CoT) approaches lack…

Computation and Language · Computer Science 2026-04-14 Zhixiang Lu , Jionglong Su

Recent studies show that deep learning models achieve good performance on medical imaging tasks such as diagnosis prediction. Among the models, multimodality has been an emerging trend, integrating different forms of data such as chest…

Machine Learning · Computer Science 2022-02-10 Haodi Zhang , Chenyu Xu , Peirou Liang , Ke Duan , Hao Ren , Weibin Cheng , Kaishun Wu

Deep search agents have proven effective in enhancing LLMs by retrieving external knowledge during multi-step reasoning. However, existing methods often generate a single query for retrieval at each reasoning step, limiting information…

Artificial Intelligence · Computer Science 2026-05-14 Jiabei Liu , Wenyu Mao , Junfei Tan , Chunxu Shen , Lingling Yi , Jiancan Wu , Xiang Wang

Large language models (LLMs) continue to struggle with knowledge-intensive questions that require up-to-date information and multi-hop reasoning. Augmenting LLMs with hybrid external knowledge, such as unstructured text and structured…

Machine Learning · Computer Science 2026-02-12 Junhong Lin , Bing Zhang , Song Wang , Ziyan Liu , Dan Gutfreund , Julian Shun , Yada Zhu

The automation of the medical evidence acquisition and diagnosis process has recently attracted increasing attention in order to reduce the workload of doctors and democratize access to medical care. However, most works proposed in the…

Computation and Language · Computer Science 2022-10-14 Arsene Fansi Tchango , Rishab Goel , Julien Martel , Zhi Wen , Gaetan Marceau Caron , Joumana Ghosn

Multimodal Large Language Models (MLLMs) have demonstrated impressive capabilities in understanding common visual elements, largely due to their large-scale datasets and advanced training strategies. However, their effectiveness in medical…

Medicine is rife with high-stakes uncertainty. Doctors routinely make clinical judgments and decisions that juggle many fundamental unknowns, like predictions about what might be causing a patients' symptoms or decisions about what…

Public health reasoning requires population level inference grounded in scientific evidence, expert consensus, and safety constraints. However, it remains underexplored as a structured machine learning problem with limited supervised…

Computation and Language · Computer Science 2026-05-27 Zhaokun Yan , Shan Xu , Wuzheng Dong , Zhaohan Liu , Lijie Feng , Chengxiao Dai , Chen Tianqi , Binfan Liu , Yunpu Ma , Wenting Wei , Yingting Li , Yi Zhang , Tongning Wu

Accurate diagnosis of Alzheimer's disease (AD) requires effectively integrating multimodal data and clinical expertise. However, existing methods often struggle to fully utilize multimodal information and lack structured mechanisms to…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Qiuhui Chen , Jintao Wang , Gang Wang , Yi Hong

While Large language models (LLMs) have proved able to address some complex reasoning tasks, we also know that they are highly sensitive to input variation, which can lead to different solution paths and final answers. Answer consistency…

Computation and Language · Computer Science 2025-03-05 Huiyuan Lai , Xiao Zhang , Malvina Nissim

Long-form mental health assessments pose unique challenges for large language models (LLMs), which often exhibit hallucinations or inconsistent reasoning when handling extended, domain-specific contexts. We introduce Stacked Multi-Model…

Computation and Language · Computer Science 2025-09-22 Jinwen Tang , Qiming Guo , Wenbo Sun , Yi Shang

Building effective clinical decision support systems requires the synthesis of complex heterogeneous multimodal data. Such modalities include temporal electronic health records data, medical images, radiology reports, and clinical notes.…

Artificial Intelligence · Computer Science 2026-05-12 Baraa Al Jorf , Farah E. Shamout

Multimodal large language models (MLLMs) have recently demonstrated remarkable reasoning abilities with reinforcement learning paradigm. Although several multimodal reasoning models have been explored in the medical domain, most of them…

Artificial Intelligence · Computer Science 2025-09-11 Ruiqi Wu , Yuang Yao , Tengfei Ma , Chenran Zhang , Na Su , Tao Zhou , Geng Chen , Wen Fan , Yi Zhou

Incentivizing the reasoning ability of Multimodal Large Language Models (MLLMs) is essential for medical applications to transparently analyze medical scans and provide reliable diagnosis. However, existing medical MLLMs rely solely on…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Lehan Wang , Yi Qin , Honglong Yang , Xiaomeng Li

Large language models (LLMs) are increasingly envisioned as decision-support tools in clinical practice, yet safe clinical reasoning demands integrating heterogeneous knowledge bases -- trials, primary studies, regulatory documents, and…

Computation and Language · Computer Science 2025-05-22 Shan Chen , Pedro Moreira , Yuxin Xiao , Sam Schmidgall , Jeremy Warner , Hugo Aerts , Thomas Hartvigsen , Jack Gallifant , Danielle S. Bitterman

Clinical reasoning refers to the cognitive process that physicians employ in evaluating and managing patients. This process typically involves suggesting necessary examinations, diagnosing patients' diseases, and deciding on appropriate…

Computation and Language · Computer Science 2024-06-11 Jiageng WU , Xian Wu , Jie Yang

Automatic detection of multimodal misinformation has gained a widespread attention recently. However, the potential of powerful Large Language Models (LLMs) for multimodal misinformation detection remains underexplored. Besides, how to…

Computation and Language · Computer Science 2024-04-09 Longzheng Wang , Xiaohan Xu , Lei Zhang , Jiarui Lu , Yongxiu Xu , Hongbo Xu , Minghao Tang , Chuang Zhang