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Medical Decision-Making (MDM) is a multi-faceted process that requires clinicians to assess complex multi-modal patient data patient, often collaboratively. Large Language Models (LLMs) promise to streamline this process by synthesizing…

Recently, multimodal large language models (MLLMs) have been widely applied to reasoning tasks. However, they suffer from limited multi-rationale semantic modeling, insufficient logical robustness, and are susceptible to misleading…

Artificial Intelligence · Computer Science 2025-12-08 Chuang Yu , Jinmiao Zhao , Mingxuan Zhao , Yunpeng Liu , Xiujun Shu , Yuanhao Feng , Bo Wang , Xiangyu Yue

While reasoning-enhanced large language models perform strongly on English medical tasks, a persistent multilingual gap remains, with substantially weaker reasoning in local languages, limiting equitable global medical deployment. To bridge…

Large Language Models (LLMs) are increasingly deployed for knowledge synthesis, yet their capacity for compositional generalization in scientific knowledge remains under-characterized. Existing benchmarks primarily focus on single-turn…

Artificial Intelligence · Computer Science 2026-05-15 Gong Zhiren , Tiantong Wu , Jiaming Zhang , Fuyao Zhang , Che Wang , Yurong Hao , Yikun Hou , Foo Ping , Yilei Zhao , Fei Huang , Chau Yuen , Wei Yang Bryan Lim

Large language models (LLMs) are increasingly used for diagnostic tasks in medicine. In clinical practice, the correct diagnosis can rarely be immediately inferred from the initial patient presentation alone. Rather, reaching a diagnosis…

Artificial Intelligence · Computer Science 2026-02-20 Hui Min Wong , Philip Heesen , Pascal Janetzky , Martin Bendszus , Stefan Feuerriegel

Large language models (LLMs) show promise in medical diagnosis, but real-world deployment remains challenging due to high-stakes clinical decisions and imperfect reasoning reliability. As a result, careful inspection of model behavior is…

Computation and Language · Computer Science 2026-04-28 Yurui Xiang , Xingyi Mao , Rui Sheng , Zixin Chen , Zelin Zang , Yuyang Wu , Haipeng Zeng , Huamin Qu , Yushi Sun , Yanna Lin

Recent progress in multimodal large language models (MLLMs) has demonstrated promising performance on medical benchmarks and in preliminary trials as clinical assistants. Yet, our pilot audit of diagnostic cases uncovers a critical failure…

Artificial Intelligence · Computer Science 2025-09-30 Hongjun Liu , Yinghao Zhu , Yuhui Wang , Yitao Long , Zeyu Lai , Lequan Yu , Chen Zhao

Despite significant progress in Multi-modal Large Language Models (MLLMs), their clinical reasoning capacity for multi-modal diagnosis remains largely unexamined. Current benchmarks, mostly single-modality data, can't evaluate progressive…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Gui Wang , Zehao Zhong , YongSong Zhou , Yudong Li , Ende Wu , Wooi Ping Cheah , Rong Qu , Jianfeng Ren , Linlin Shen

The emergence of advanced reasoning capabilities in Large Language Models (LLMs) marks a transformative development in healthcare applications. Beyond merely expanding functional capabilities, these reasoning mechanisms enhance decision…

Artificial Intelligence · Computer Science 2025-08-27 Armin Berger , Sarthak Khanna , David Berghaus , Rafet Sifa

The application of large language models (LLMs) in clinical decision support faces significant challenges of "tunnel vision" and diagnostic hallucinations present in their processing unstructured electronic health records (EHRs). To address…

Artificial Intelligence · Computer Science 2026-04-28 Zhiqi Lv , Duofan Tu , Jun Li , Mingyue Zhao , Heqin Zhu , Wenliang Li , Shaohua Kevin Zhou

Understanding the contents of multimodal documents is essential to accurately extract relevant evidence and use it for reasoning. Existing document understanding models tend to generate answers with a single word or phrase directly,…

Information Retrieval · Computer Science 2024-08-15 Jinxu Zhang

Clinical practice guidelines (CPGs) encode evidence-based decision logic that clinicians apply by evaluating patient variables, conditional criteria, and recommendation rules. However, existing methods often use CPGs as free-text training…

Artificial Intelligence · Computer Science 2026-05-27 Yuhao Shen , Lang Cao , Simo Du , Yuqing Wang , Juexiao Zhou , Hao Peng , Yue Guo

Empowered by vast internal knowledge reservoir, the new generation of large language models (LLMs) demonstrate untapped potential to tackle medical tasks. However, there is insufficient effort made towards summoning up a synergic effect…

Computation and Language · Computer Science 2025-05-23 Kexin Shang , Chia-Hsuan Chang , Christopher C. Yang

Large Language Models (LLMs) are increasingly deployed in critical applications requiring reliable reasoning, yet their internal reasoning processes remain difficult to evaluate systematically. Existing methods focus on final-answer…

Machine Learning · Computer Science 2026-02-03 Shaima Ahmad Freja , Ferhat Ozgur Catak , Betul Yurdem , Chunming Rong

While large language models (LLMs) leverage both knowledge and reasoning during inference, the capacity to distinguish between them plays a pivotal role in model analysis, interpretability, and development. Inspired by dual-system cognitive…

Artificial Intelligence · Computer Science 2025-07-25 Mutian Yang , Jiandong Gao , Ji Wu

Large language models (LLMs) have excelled across domains, also delivering notable performance on the medical evaluation benchmarks, such as MedQA. However, there still exists a significant gap between the reported performance and the…

Computation and Language · Computer Science 2024-06-06 Yuxuan Zhou , Xien Liu , Chen Ning , Ji Wu

The adoption of large language models (LLMs) in healthcare has attracted significant research interest. However, their performance in healthcare remains under-investigated and potentially limited, due to i) they lack rich domain-specific…

Artificial Intelligence · Computer Science 2024-05-21 Zishan Gu , Fenglin Liu , Changchang Yin , Ping Zhang

Intrinsic image decomposition aims to separate images into physical components such as albedo, depth, normals, and illumination. While recent diffusion- and transformer-based models benefit from paired supervision from synthetic datasets,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-05 Alara Dirik , Tuanfeng Wang , Duygu Ceylan , Stefanos Zafeiriou , Anna Frühstück

Large Language Models (LLMs) have made significant progress in various fields. However, challenges remain in Multi-Disciplinary Team (MDT) medical consultations. Current research enhances reasoning through role assignment, task…

Artificial Intelligence · Computer Science 2025-03-19 Kai Chen , Xinfeng Li , Tianpei Yang , Hewei Wang , Wei Dong , Yang Gao

Large Language Models (LLMs) are evolving at an unprecedented pace and have exhibited considerable capability in the realm of natural language processing (NLP) with world knowledge. Benefiting from ultra-large-scale training corpora, a…

Artificial Intelligence · Computer Science 2024-08-22 Qiushi Sun , Zhangyue Yin , Xiang Li , Zhiyong Wu , Xipeng Qiu , Lingpeng Kong