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Early diagnosis of Alzheimer's disease (AD) remains a major challenge due to the subtle and temporally irregular progression of structural brain changes in the prodromal stages. Existing deep learning approaches require large longitudinal…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Maxx Richard Rahman , Mostafa Hammouda , Wolfgang Maass

Seizure detection from EEGs is a challenging and time consuming clinical problem that would benefit from the development of automated algorithms. EEGs can be viewed as structural time series, because they are multivariate time series where…

Machine Learning · Computer Science 2019-05-07 Ian Covert , Balu Krishnan , Imad Najm , Jiening Zhan , Matthew Shore , John Hixson , Ming Jack Po

Over the past decade a wide spectrum of machine learning models have been developed to model the neurodegenerative diseases, associating biomarkers, especially non-intrusive neuroimaging markers, with key clinical scores measuring the…

Machine Learning · Computer Science 2018-03-02 Mengying Sun , Inci M. Baytas , Liang Zhan , Zhangyang Wang , Jiayu Zhou

Major depressive disorder (MDD) requires study of brain functional connectivity alterations for patients, which can be uncovered by resting-state functional magnetic resonance imaging (rs-fMRI) data. We consider the problem of identifying…

Machine Learning · Statistics 2022-06-10 Shuai Liu , Yixuan Qiu , Baojuan Li , Huaning Wang , Xiangyu Chang

Time series generation (TSG) is widely used across domains, yet most existing methods assume regular sampling and fixed output resolutions. These assumptions are often violated in practice, where observations are irregular and sparse, while…

Machine Learning · Computer Science 2026-02-02 Xu Zhang , Junwei Deng , Chang Xu , Hao Li , Jiang Bian

With the increasing demand for real-time Electrocardiogram (ECG) classification on edge devices, existing models face challenges of high computational cost and limited accuracy on imbalanced datasets.This paper presents Multi-task DFNet, a…

Signal Processing · Electrical Eng. & Systems 2025-11-19 Lehuai Xu , Zirui Lu , Haoran Yang , Yina Zhou

Brain network analysis plays a crucial role in diagnosing and monitoring neurodegenerative disorders such as Alzheimer's disease (AD). Existing approaches for constructing structural brain networks from diffusion tensor imaging (DTI) often…

Neurons and Cognition · Quantitative Biology 2025-05-30 Xuhang Chen , Michael Kwok-Po Ng , Kim-Fung Tsang , Chi-Man Pun , Shuqiang Wang

Longitudinal neuroimaging is essential for modeling disease progression in Alzheimer's disease (AD), yet irregular sampling and missing visits pose substantial challenges for learning reliable temporal representations. To address this…

Machine Learning · Computer Science 2026-03-24 Ruiying Chen , Yutong Wang , Houliang Zhou , Wei Liang , Yong Chen , Lifang He

Predicting the effect of amino acid mutations on enzyme thermodynamic stability (DDG) is fundamental to protein engineering and drug design. While recent deep learning approaches have shown promise, they often process sequence and structure…

Machine Learning · Computer Science 2025-11-10 Abigail Lin

Electroencephalography (EEG) signal decoding is a key technology that translates brain activity into executable commands, laying the foundation for direct brain-machine interfacing and intelligent interaction. To address the inherent…

Machine Learning · Computer Science 2026-01-05 Xiangrui Cai , Shaocheng Ma , Lei Cao , Jie Li , Tianyu Liu , Yilin Dong

Recommendation systems in AI-based medical diagnostics and treatment constitute a critical component of AI in healthcare. Although some studies have explored this area and made notable progress, healthcare recommendation systems remain in…

Information Retrieval · Computer Science 2025-05-13 Jianan Li , Yangtao Zhou , Zhifu Zhao , Qinglan Huang , Jian Qi , Xiao He , Hua Chu , Fu Li

Medical time series has been playing a vital role in real-world healthcare systems as valuable information in monitoring health conditions of patients. Accurate classification for medical time series, e.g., Electrocardiography (ECG)…

Machine Learning · Computer Science 2025-02-10 Wei Fan , Jingru Fei , Dingyu Guo , Kun Yi , Xiaozhuang Song , Haolong Xiang , Hangting Ye , Min Li

Alzheimer's Disease is a progressive neurological disorder that is one of the most common forms of dementia. It leads to a decline in memory, reasoning ability, and behavior, especially in older people. The cause of Alzheimer's Disease is…

Machine Learning · Computer Science 2025-04-03 Jing Wang , Jun-En Ding , Feng Liu , Elisa Kallioniemi , Shuqiang Wang , Wen-Xiang Tsai , Albert C. Yang

Alzheimer's disease (AD) and sleep disorders exhibit a close association, where disruptions in sleep patterns often precede the onset of Mild Cognitive Impairment (MCI) and early-stage AD. This study delves into the potential of utilizing…

Spiking Neural Networks (SNNs), with their brain-inspired spatiotemporal dynamics and spike-driven computation, have emerged as promising energy-efficient alternatives to Artificial Neural Networks (ANNs). However, existing SNNs typically…

Computer Vision and Pattern Recognition · Computer Science 2025-12-03 Fan Luo , Zeyu Gao , Xinhao Luo , Kai Zhao , Yanfeng Lu

Lung cancer continues to be the leading cause of cancer-related deaths globally. Early detection and diagnosis of pulmonary nodules are essential for improving patient survival rates. Although previous research has integrated multimodal and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-25 Xiao Yu , Zhaojie Fang , Guanyu Zhou , Yin Shen , Huoling Luo , Ye Li , Ahmed Elazab , Xiang Wan , Ruiquan Ge , Changmiao Wang

A vast majority of spiking neural networks (SNNs) are trained based on inductive biases that are not necessarily a good fit for several critical tasks that require low-latency and power efficiency. Inferring brain behavior based on the…

Neural and Evolutionary Computing · Computer Science 2023-04-20 Xi Chen , Siwei Mai , Konstantinos Michmizos

In real-world applications of noninvasive electroencephalography (EEG), specialized decoders often show limited generalizability across diverse tasks under subject-independent settings. One central challenge is that task-relevant EEG…

Artificial Intelligence · Computer Science 2026-04-21 Zhiyuan Ma , Zeyuan Li , Zihao Qiu , Jinhao Li , Lingqin Meng , Xinche Zhang , Yixuan Liu , Xinke Shen , Sen Song

Recently, researchers have begun to experiment with deep learning-based methods for detecting major depressive disor-der (MDD) using electroencephalogram (EEG) signals in search of a more objective means of diagnosis. However, exist-ing…

Machine Learning · Computer Science 2026-02-02 Chen-Yang Xu , Han-Guang Wang , Lan Zhang , Yong-Hui Zhang , Hui-Rang Hou , Qing-Hao Meng

Surface electromyography (sEMG)-based gesture recognition plays a critical role in human-machine interaction (HMI), particularly for rehabilitation and prosthetic control. However, sEMG-based systems often suffer from the scarcity of…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Chen Liu , Can Han , Weishi Xu , Yaqi Wang , Dahong Qian
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