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Optical Chemical Structure Recognition (OCSR) plays a pivotal role in modern chemical informatics, enabling the automated conversion of chemical structure images from scientific literature, patents, and educational materials into…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Wenrui Zhang , Xinggang Wang , Bin Feng , Wenyu Liu

Optical Chemical Structure Recognition (OCSR) is critical for converting 2D molecular diagrams from printed literature into machine-readable formats. While Vision-Language Models have shown promise in end-to-end OCR tasks, their direct…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Haocheng Tang , Xingyu Dang , Junmei Wang

Optical Chemical Structure Recognition (OCSR) is essential for converting molecular images into machine-readable formats. While recent vision-language models (VLMs) have shown promise, their image-captioning approach often struggles with…

Artificial Intelligence · Computer Science 2026-01-14 Jingchao Wang , Yifan He , Haote Yang , Jiang Wu , Lingli Ge , Xingjian Wei , Yinfan Wang , Linye Li , Huijie Ao , Chengjin Liu , Bin Wang , Lijun Wu , Conghui He

Identifying the chemical structure from a graphical representation, or image, of a molecule is a challenging pattern recognition task that would greatly benefit drug development. Yet, existing methods for chemical structure recognition do…

Computer Vision and Pattern Recognition · Computer Science 2024-04-03 Martijn Oldenhof , Edward De Brouwer , Adam Arany , Yves Moreau

Optical chemical structure recognition (OCSR) systems aim to extract the molecular structure information, usually in the form of molecular graph or SMILES, from images of chemical molecules. While many tools have been developed for this…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 Ching Ting Leung , Yufan Chen , Hanyu Gao

Understanding the chemical structure from a graphical representation of a molecule is a challenging image caption task that would greatly benefit molecule-centric scientific discovery. Variations in molecular images and caption subtasks…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Siqi Fan , Yuguang Xie , Bowen Cai , Ailin Xie , Gaochao Liu , Mu Qiao , Jie Xing , Zaiqing Nie

The crucial field of Optical Chemical Structure Recognition (OCSR) aims to transform chemical structure photographs into machine-readable formats so that chemical databases may be efficiently stored and queried. Although a number of OCSR…

Machine Learning · Computer Science 2025-02-25 Zishuo Lin , Jiajie Wang , Zhe Yan , Peiyong Ma

Optical Chemical Structure Recognition (OCSR) aims to translate molecular diagrams in scientific literature into machine-readable formats, but current systems remain unreliable on real-world images due to substantial visual and chemical…

In recent years, self-supervised learning has emerged as a powerful tool to harness abundant unlabelled data for representation learning and has been broadly adopted in diverse areas. However, when applied to molecular representation…

Machine Learning · Computer Science 2024-02-22 Han Tang , Shikun Feng , Bicheng Lin , Yuyan Ni , JIngjing Liu , Wei-Ying Ma , Yanyan Lan

In the field of chemical structure recognition, the task of converting molecular images into machine-readable data formats such as SMILES string stands as a significant challenge, primarily due to the varied drawing styles and conventions…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Yufan Chen , Ching Ting Leung , Yong Huang , Jianwei Sun , Hao Chen , Hanyu Gao

Molecular structures are always depicted as 2D printed form in scientific documents like journal papers and patents. However, these 2D depictions are not machine-readable. Due to a backlog of decades and an increasing amount of these…

Computer Vision and Pattern Recognition · Computer Science 2022-05-24 Youjun Xu , Jinchuan Xiao , Chia-Han Chou , Jianhang Zhang , Jintao Zhu , Qiwan Hu , Hemin Li , Ningsheng Han , Bingyu Liu , Shuaipeng Zhang , Jinyu Han , Zhen Zhang , Shuhao Zhang , Weilin Zhang , Luhua Lai , Jianfeng Pei

In recent decades, chemistry publications and patents have increased rapidly. A significant portion of key information is embedded in molecular structure figures, complicating large-scale literature searches and limiting the application of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Xi Fang , Jiankun Wang , Xiaochen Cai , Shangqian Chen , Shuwen Yang , Haoyi Tao , Nan Wang , Lin Yao , Linfeng Zhang , Guolin Ke

Optical Character Recognition (OCR) is a fundamental task for digitizing information, serving as a critical bridge between visual data and textual understanding. While modern Vision-Language Models (VLM) have achieved high accuracy in this…

Computer Vision and Pattern Recognition · Computer Science 2026-05-28 Sean Man , Gilad Deutch , Roy Ganz , Roi Ronen , Shahar Tsiper , Shai Mazor , Niv Nayman

Compression technology is essential for efficient image transmission and storage. With the rapid advances in deep learning, images are beginning to be used for image recognition as well as for human vision. For this reason, research has…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Takahiro Shindo , Taiju Watanabe , Kein Yamada , Hiroshi Watanabe

Machine learning methods have been used to accelerate the molecule optimization process. However, efficient search for optimized molecules satisfying several properties with scarce labeled data remains a challenge for machine learning…

Biomolecules · Quantitative Biology 2022-12-20 Xin Xia , Yansen Su , Chunhou Zheng , Xiangxiang Zeng

Existing Multimodal Large Language Models (MLLMs) suffer from increased inference costs due to the additional vision tokens introduced by image inputs. In this work, we propose Visual Consistency Learning (ViCO), a novel training algorithm…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Long Cui , Weiyun Wang , Jie Shao , Zichen Wen , Gen Luo , Linfeng Zhang , Yanting Zhang , Yu Qiao , Wenhai Wang

Modern research increasingly relies on automated methods to assist researchers. An example of this is Optical Chemical Structure Recognition (OCSR), which aids chemists in retrieving information about chemicals from large amounts of…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Thomas Jurriaans , Kinga Szarkowska , Eric Nalisnick , Markus Schwoerer , Camilo Thorne , Saber Akhondi

The rise of multi-modal search requests from users has highlighted the importance of multi-modal retrieval (i.e. image-to-text or text-to-image retrieval), yet the more complex task of image-to-multi-modal retrieval, crucial for many…

Information Retrieval · Computer Science 2024-06-11 Zida Cheng , Chen Ju , Shuai Xiao , Xu Chen , Zhonghua Zhai , Xiaoyi Zeng , Weilin Huang , Junchi Yan

Fueled by deep learning, computer-aided diagnosis achieves huge advances. However, out of controlled lab environments, algorithms could face multiple challenges. Open set recognition (OSR), as an important one, states that categories unseen…

Computer Vision and Pattern Recognition · Computer Science 2023-07-24 Mingyuan Liu , Lu Xu , Jicong Zhang

Realizing high-throughput aberration-corrected Scanning Transmission Electron Microscopy (STEM) exploration of atomic structures requires rapid tuning of multipole probe correctors while compensating for the inevitable drift of the optical…

Machine Learning · Computer Science 2026-01-28 Utkarsh Pratiush , Austin Houston , Richard Liu , Gerd Duscher , Sergei Kalinin
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