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Large language models (LLMs) have demonstrated remarkable advances in reasoning capabilities. However, their performance remains constrained by limited access to explicit and structured domain knowledge. Retrieval-Augmented Generation (RAG)…

Computation and Language · Computer Science 2025-10-20 Junlin Wu , Xianrui Zhong , Jiashuo Sun , Bolian Li , Bowen Jin , Jiawei Han , Qingkai Zeng

This paper presents an experience report on the development of Retrieval Augmented Generation (RAG) systems using PDF documents as the primary data source. The RAG architecture combines generative capabilities of Large Language Models…

Software Engineering · Computer Science 2024-10-22 Ayman Asad Khan , Md Toufique Hasan , Kai Kristian Kemell , Jussi Rasku , Pekka Abrahamsson

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge, where the LLM's ability to generate responses based on the combination of a given query and retrieved documents is crucial.…

Computation and Language · Computer Science 2025-08-01 Zhehao Tan , Yihan Jiao , Dan Yang , Lei Liu , Jie Feng , Duolin Sun , Yue Shen , Jian Wang , Peng Wei , Jinjie Gu

Large language models (LLMs) have recently become the leading source of answers for users' questions online. Despite their ability to offer eloquent answers, their accuracy and reliability can pose a significant challenge. This is…

Computation and Language · Computer Science 2024-07-09 Bojana Bašaragin , Adela Ljajić , Darija Medvecki , Lorenzo Cassano , Miloš Košprdić , Nikola Milošević

Protein--ligand docking is widely used in structure-based discovery, but routine studies often fail at the workflow level rather than at the scoring level. Receptor cleaning, ligand preparation, file conversion, box definition, run…

Quantitative Methods · Quantitative Biology 2026-04-24 Tieu-Long Phan , Lai Hoang Son Le , Thanh-An Pham , Nhu-Ngoc Nguyen Song , Tuyet-Minh Phan , Tuyen Ngoc Truong

Biomedical semantic question answering rooted in information retrieval can play a crucial role in keeping up to date with vast, rapidly evolving and ever-growing biomedical literature. A robust system can help researchers, healthcare…

Information Retrieval · Computer Science 2025-07-09 Shashank Verma , Fengyi Jiang , Xiangning Xue

Millions of people in African countries face barriers to accessing healthcare due to language and literacy gaps. This research tackles this challenge by transforming complex medical documents -- in this case, prosthetic device user manuals…

The global demand for sustainable protein sources has accelerated the need for intelligent tools that can rapidly process and synthesise domain-specific scientific knowledge. In this study, we present a proof-of-concept multi-agent…

Artificial Intelligence · Computer Science 2025-06-26 Alexander D. Kalian , Jaewook Lee , Stefan P. Johannesson , Lennart Otte , Christer Hogstrand , Miao Guo

Retrieval-Augmented Generation (RAG) has established itself as the standard paradigm for grounding Large Language Models (LLMs) in domain-specific, up-to-date data. However, the prevailing architecture for RAG has evolved into a complex,…

Information Retrieval · Computer Science 2026-02-27 Ahmed Bin Khalid

Retrieval-Augmented Generation (RAG) systems using Multimodal Large Language Models (MLLMs) show great promise for complex document understanding, yet their development is critically hampered by inadequate evaluation. Current benchmarks…

Computation and Language · Computer Science 2025-08-06 Wenxuan Shen , Mingjia Wang , Yaochen Wang , Dongping Chen , Junjie Yang , Yao Wan , Weiwei Lin

Purpose: Large Language Models (LLMs) hold significant promise for medical applications. Retrieval Augmented Generation (RAG) emerges as a promising approach for customizing domain knowledge in LLMs. This case study presents the development…

The question-answering system for Life science research, which is characterized by the rapid pace of discovery, evolving insights, and complex interactions among knowledge entities, presents unique challenges in maintaining a comprehensive…

Computation and Language · Computer Science 2024-08-15 Chengrui Wang , Qingqing Long , Meng Xiao , Xunxin Cai , Chengjun Wu , Zhen Meng , Xuezhi Wang , Yuanchun Zhou

This study develops a question-answering system based on Retrieval-Augmented Generation (RAG) using Chinese Wikipedia and Lawbank as retrieval sources. Using TTQA and TMMLU+ as evaluation datasets, the system employs BGE-M3 for dense vector…

Information Retrieval · Computer Science 2025-01-17 Te-Lun Yang , Jyi-Shane Liu , Yuen-Hsien Tseng , Jyh-Shing Roger Jang

The Protein Data Bank (PDB) contains more than 135 000 entries today. From these, relatively few amyloid structures can be identified, since amyloids are insoluble in water. Therefore, mostly solid state NMR-recorded amyloid structures are…

Biomolecules · Quantitative Biology 2018-05-28 Kristof Takacs , Balint Varga , Vince Grolmusz

Retrieval-Augmented Generation (RAG) integrates external knowledge with Large Language Models (LLMs) to enhance factual correctness and mitigate hallucination. However, dense retrievers often become the bottleneck of RAG systems due to…

Computation and Language · Computer Science 2025-10-27 Yuan Li , Qi Luo , Xiaonan Li , Bufan Li , Qinyuan Cheng , Bo Wang , Yining Zheng , Yuxin Wang , Zhangyue Yin , Xipeng Qiu

Electronic logbooks contain valuable information about activities and events concerning their associated particle accelerator facilities. However, the highly technical nature of logbook entries can hinder their usability and automation. As…

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Terpenoids are a crucial class of natural products that have been studied for over 150 years, but their interdisciplinary nature (spanning chemistry, pharmacology, and biology) complicates knowledge integration. To address this, the authors…

Information Retrieval · Computer Science 2025-05-28 Xu Kang , Siqi Jiang , Kangwei Xu , Jiahao Li , Ruibo Wu

This paper summarizes our work on the first track of the ninth Dialog System Technology Challenge (DSTC 9), "Beyond Domain APIs: Task-oriented Conversational Modeling with Unstructured Knowledge Access". The goal of the task is to generate…

Computation and Language · Computer Science 2021-02-10 David Thulke , Nico Daheim , Christian Dugast , Hermann Ney

Structural drawings are widely used in many fields, e.g., mechanical engineering, civil engineering, etc. In civil engineering, structural drawings serve as the main communication tool between architects, engineers, and builders to avoid…

Machine Learning · Computer Science 2025-07-29 Xin Zhang , Lissette Iturburu , Juan Nicolas Villamizar , Xiaoyu Liu , Manuel Salmeron , Shirley J. Dyke , Julio Ramirez