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Going beyond correlations, the understanding and identification of causal relationships in observational time series, an important subfield of Causal Discovery, poses a major challenge. The lack of access to a well-defined ground truth for…

Machine Learning · Statistics 2021-04-19 Andrew R. Lawrence , Marcus Kaiser , Rui Sampaio , Maksim Sipos

Time-to-event estimands are central to many oncology clinical trials. The estimand framework (addendum to the ICH E9 guideline) calls for precisely defining the treatment effect of interest to align with the clinical question of interest…

Applications · Statistics 2023-07-24 Jonathan Siegel , Hans-Jochen Weber , Stefan Englert , Feng Liu

Embeddings of medical concepts such as medication, procedure and diagnosis codes in Electronic Medical Records (EMRs) are central to healthcare analytics. Previous work on medical concept embedding takes medical concepts and EMRs as words…

Computation and Language · Computer Science 2018-06-11 Xiangrui Cai , Jinyang Gao , Kee Yuan Ngiam , Beng Chin Ooi , Ying Zhang , Xiaojie Yuan

Event temporal reasoning aims at identifying the temporal relations between two or more events from narratives. However, knowledge conflicts arise when there is a mismatch between the actual temporal relations of events in the context and…

Computation and Language · Computer Science 2024-04-09 Tianqing Fang , Zhaowei Wang , Wenxuan Zhou , Hongming Zhang , Yangqiu Song , Muhao Chen

Temporal information extraction from unstructured text is essential for contextualizing events and deriving actionable insights, particularly in the medical domain. We address the task of extracting clinical events and their temporal…

Computation and Language · Computer Science 2026-01-22 Rochana Chaturvedi , Peyman Baghershahi , Sourav Medya , Barbara Di Eugenio

Time series data measure how environments change over time and drive decision-making in critical domains like finance and healthcare. A common goal in analyzing time series data is to understand the underlying events that cause the observed…

Artificial Intelligence · Computer Science 2025-05-26 Mingtian Tan , Mike A. Merrill , Zack Gottesman , Tim Althoff , David Evans , Tom Hartvigsen

Continuous-time event data are common in applications such as individual behavior data, financial transactions, and medical health records. Modeling such data can be very challenging, in particular for applications with many different types…

Machine Learning · Statistics 2020-11-09 Alex Boyd , Robert Bamler , Stephan Mandt , Padhraic Smyth

The times of temporal-network events and their correlations contain information on the function of the network and they influence dynamical processes taking place on it. To extract information out of correlated event times, techniques such…

Physics and Society · Physics 2019-12-10 Jari Saramäki , Mikko Kivelä , Márton Karsai

We explore the hyperparameters and introduce a methodological framework to convert disease patterns from time series data of blood test results into correlation graphs for causal hypothesis exploration. The networks represent hypotheses…

Other Quantitative Biology · Quantitative Biology 2025-12-29 David Patrick Duys Montealegre , Alexander Fulton , Mahta Haghighat Ghahfarokhi , Abicumaran Uthamacumaran , Hector Zenil

The problem of named entity recognition in the medical/clinical domain has gained increasing attention do to its vital role in a wide range of clinical decision support applications. The identification of complete and correct term span is…

Computation and Language · Computer Science 2013-10-03 Azad Dehghan

Modern high-stakes systems, such as healthcare or robotics, often generate vast streaming event sequences. Our goal is to design an efficient, plug-and-play tool to elicit logic tree-based explanations from Large Language Models (LLMs) to…

Machine Learning · Computer Science 2024-07-01 Zitao Song , Chao Yang , Chaojie Wang , Bo An , Shuang Li

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and…

Quantitative Methods · Quantitative Biology 2024-04-25 Alan D. Kaplan , Priyadip Ray , John D. Greene , Vincent X. Liu

Intensity-based multistate models provide a useful framework for characterizing disease processes, the introduction of interventions, loss to follow-up, and other complications arising in the conduct of randomized trials studying complex…

Methodology · Statistics 2022-09-29 Alexandra Bühler , Richard J. Cook , Jerald F. Lawless

Computational modeling is crucial for understanding and analyzing complex systems. In biology, model creation is a human dependent task that requires reading hundreds of papers and conducting wet lab experiments, which would take days or…

Quantitative Methods · Quantitative Biology 2021-10-22 Yasmine Ahmed , Natasa Miskov-Zivanov

Many diseases, including cancer and chronic conditions, require extended treatment periods and long-term strategies. Machine learning and AI research focusing on electronic health records (EHRs) have emerged to address this need. Effective…

Temporal point processes (TPPs) are widely used to model the timing and occurrence of events in domains such as social networks, transportation systems, and e-commerce. In this paper, we introduce TPP-LLM, a novel framework that integrates…

Machine Learning · Computer Science 2025-06-11 Zefang Liu , Yinzhu Quan

Events are fundamental for understanding how people experience their lives. It is challenging, however, to automatically record all events in daily life. An understanding of multimedia signals allows recognizing events of daily living and…

Human-Computer Interaction · Computer Science 2019-05-24 Hyungik Oh , Ramesh Jain

Irregular sampling occurs in many time series modeling applications where it presents a significant challenge to standard deep learning models. This work is motivated by the analysis of physiological time series data in electronic health…

Machine Learning · Computer Science 2021-06-08 Satya Narayan Shukla , Benjamin M. Marlin

Synthetic medical data which preserves privacy while maintaining utility can be used as an alternative to real medical data, which has privacy costs and resource constraints associated with it. At present, most models focus on generating…

Machine Learning · Computer Science 2019-11-28 Saloni Dash , Ritik Dutta , Isabelle Guyon , Adrien Pavao , Andrew Yale , Kristin P. Bennett

Temporal network data are increasingly available in various domains, and often represent highly complex systems with intricate structural and temporal evolutions. Due to the difficulty of processing such complex data, it may be useful to…

Physics and Society · Physics 2023-05-08 Chanon Thongprayoon , Lorenzo Livi , Naoki Masuda