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Heterogeneous graph neural networks (HGNNs) are essential for capturing the structure and semantic information in heterogeneous graphs. However, existing GPU-based solutions, such as PyTorch Geometric, suffer from low GPU utilization due to…

Hardware Architecture · Computer Science 2024-08-19 Meng Wu , Jingkai Qiu , Mingyu Yan , Wenming Li , Yang Zhang , Zhimin Zhang , Xiaochun Ye , Dongrui Fan

As Graph Neural Networks (GNNs) become popular, libraries like PyTorch-Geometric (PyG) and Deep Graph Library (DGL) are proposed; these libraries have emerged as the de facto standard for implementing GNNs because they provide…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-02-29 Yi-Chien Lin , Yuyang Chen , Sameh Gobriel , Nilesh Jain , Gopi Krishna Jha , Viktor Prasanna

Classical molecular dynamics (MD) simulations are important tools in life and material sciences since they allow studying chemical and biological processes in detail. However, the inherent scalability problem of particle-particle…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-08-14 Michael Schaffner , Luca Benini

Graph Convolutional Networks (GCNs) have emerged as the state-of-the-art graph learning model. However, it can be notoriously challenging to inference GCNs over large graph datasets, limiting their application to large real-world graphs and…

Hardware Architecture · Computer Science 2025-03-11 Haoran You , Tong Geng , Yongan Zhang , Ang Li , Yingyan Celine Lin

We present an alternative method for genome-wide association studies (GWAS) that is more powerful than the regular GWAS method for locus detection. The regular GWAS method suffers from a substantial multiple-testing burden because of the…

Applications · Statistics 2018-12-19 William Denault , Håkon K. Gjessing , Julius Juodakis , Bo Jacobsson , Astanand Jugessur

Stochastic simulation techniques employed for the analysis of portfolios of insurance/reinsurance risk, often referred to as `Aggregate Risk Analysis', can benefit from exploiting state-of-the-art high-performance computing platforms. In…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-08-19 A. K. Bahl , O. Baltzer , A. Rau-Chaplin , B. Varghese , A. Whiteway

Assessing the statistical power to detect susceptibility variants plays a critical role in GWA studies both from the prospective and retrospective points of view. Power is empirically estimated by simulating phenotypes under a disease model…

Applications · Statistics 2012-01-25 Vittorio Perduca , Christine Sinoquet , Raphael Mourad , Gregory Nuel

While the advances in synchrotron light sources, together with the development of focusing optics and detectors, allow nanoscale ptychographic imaging of materials and biological specimens, the corresponding experiments can yield…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-04-05 Xiaodong Yu , Viktor Nikitin , Daniel J. Ching , Selin Aslan , Doga Gursoy , Tekin Bicer

Presented here is a simple method for cross-validated genome-wide association studies (cvGWAS). Focusing on phenotype prediction, the method is able to reveal a significant amount of missing heritability by properly selecting a small number…

Quantitative Methods · Quantitative Biology 2013-08-08 Xia Shen

SHAP (SHapley Additive exPlanation) values provide a game theoretic interpretation of the predictions of machine learning models based on Shapley values. While exact calculation of SHAP values is computationally intractable in general, a…

Machine Learning · Computer Science 2022-02-04 Rory Mitchell , Eibe Frank , Geoffrey Holmes

Out-of-focus microscopy lens in digital pathology is a critical bottleneck in high-throughput Whole Slide Image (WSI) scanning platforms, for which pixel-level automated Focus Quality Assessment (FQA) methods are highly desirable to help…

Image and Video Processing · Electrical Eng. & Systems 2020-10-02 Zhongling Wang , Mahdi S. Hosseini , Adyn Miles , Konstantinos N. Plataniotis , Zhou Wang

Genetic Algorithms (GAs) are used to solve search and optimization problems in which an optimal solution can be found using an iterative process with probabilistic and non-deterministic transitions. However, depending on the problem's…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-01-23 Matheus F. Torquato , Marcelo A. C. Fernandes

Packet classification is a core function in software-defined networks, and learning-based methods have recently shown significant throughput gains on large-scale rulesets. However, existing learning-based approaches struggle with…

Networking and Internet Architecture · Computer Science 2026-01-07 Zhengyu Liao , Shiyou Qian

GPUs are the dominant platform for many important applications today including deep learning, accelerated computing, and scientific simulation. However, as the complexity of both applications and hardware increases, GPU chip manufacturers…

Hardware Architecture · Computer Science 2025-09-29 Ian McDougall , Michael Davies , Rahul Chatterjee , Somesh Jha , Karthikeyan Sankaralingam

Modern genomics research relies on genome-wide association studies (GWAS) to identify the few genetic variants among potentially millions that are associated with diseases of interest. Only reproducible discoveries of groups of associations…

Methodology · Statistics 2024-10-08 Jasin Machkour , Michael Muma , Daniel P. Palomar

Surface wave tomography is essential for investigating the shear-wave velocity structure of the crust and upper mantle. The direct surface wave tomography method, DSurfTomo, has become one of the most widely adopted packages due to its…

Geophysics · Physics 2026-04-15 Shaohang Zhu , Junlun Li , Guoyi Chen , Hongjian Fang , Huajian Yao

Graph Neural Networks (GNNs) are emerging as a powerful tool for learning from graph-structured data and performing sophisticated inference tasks in various application domains. Although GNNs have been shown to be effective on modest-sized…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-05-29 Jeongmin Brian Park , Vikram Sharma Mailthody , Zaid Qureshi , Wen-mei Hwu

We present GFORS, a GPU-accelerated framework for large binary integer programs. It couples a first-order (PDHG-style) routine that guides the search in the continuous relaxation with a randomized, feasibility-aware sampling module that…

Optimization and Control · Mathematics 2025-11-03 Ningji Wei , Jiaming Liang

We present an improvement of our implementation of the Correlation Technique for the Fourier Domain Acceleration Search (FDAS) algorithm on Graphics Processor Units (GPUs) (Dimoudi & Armour 2015; Dimoudi et al. 2017). Our new improved…

Instrumentation and Methods for Astrophysics · Physics 2017-11-30 Karel Adámek , Sofia Dimoudi , Mike Giles , Wesley Armour

Modern deep learning workloads often consist of many small tensor operations, especially in inference, attention, and micro-batched training. In these settings, kernel launch overhead can become a major bottleneck, sometimes exceeding the…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-21 Yiwei Yang , Xiangyu Gao , Yuan Zhou , Yuhang Gan , Yusheng Zheng , Andi Quinn