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Genome variants which re-occur independently across evolutionary lineages are key molecular signatures of adaptation. Inferring the dynamics of such genetic changes from pandemic-scale genomic datasets is now possible, which opens up…

We now need more than ever to make genome analysis more intelligent. We need to read, analyze, and interpret our genomes not only quickly, but also accurately and efficiently enough to scale the analysis to population level. There currently…

It is estimated that approximately 15% of cancers worldwide can be linked to viral infections. The viruses that can cause or increase the risk of cancer include human papillomavirus, hepatitis B and C viruses, Epstein-Barr virus, and human…

Genomics · Quantitative Biology 2023-08-30 Shorya Consul , John Robertson , Haris Vikalo

In this paper we present VART, a tool for automatically revealing regression faults missed by regression test suites. Interestingly, VART is not limited to faults causing crashing or exceptions, but can reveal faults that cause the…

Software Engineering · Computer Science 2017-08-08 Fabrizio Pastore , Leonardo Mariani

Multimodal learning combining pathology images and genomic sequences enhances cancer survival analysis but faces clinical implementation barriers due to limited access to genomic sequencing in under-resourced regions. To enable survival…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Zizhi Chen , Minghao Han , Xukun Zhang , Shuwei Ma , Tao Liu , Xing Wei , Lihua Zhang

The Third-Generation in DNA sequencing has emerged in the last few years using new technologies that allow the production of long-read sequences. Applications of the Third-Generation sequencing enable real-time and on-site data production,…

Populations and Evolution · Quantitative Biology 2019-02-26 Hyunjin Shim

In order to prevent detection and evade signature-based scanning methods, which are normally exploited by antivirus software, metamorphic viruses use several various obfuscation approaches. They transform their code in new instances as look…

Cryptography and Security · Computer Science 2011-04-19 Babak Bashari Rad , Maslin Masrom

RNA viruses form genetically diverse populations structured as mutant spectra, or quasispecies, whose internal organization influences their evolutionary and adaptive dynamics. While genetic diversity has been extensively characterized, the…

Variant calling is a fundamental task in genomic research, essential for detecting genetic variations such as single nucleotide polymorphisms (SNPs) and insertions or deletions (indels). This paper presents an enhancement to DeepChem, a…

Quantitative Methods · Quantitative Biology 2025-07-29 Ankita Vaishnobi Bisoi , Shreyas V , Jose Siguenza , Bharath Ramsundar

This study presents a novel approach at the intersection of genomic analysis and artificial intelligence (AI) to predict viral mutations and assess the risks of future pandemics. Through comprehensive genomic analysis, genetic markers…

Other Quantitative Biology · Quantitative Biology 2023-09-29 Fadhil G. Al-Amran , Abbas M. Hezam , Salman Rawaf , Maitham G. Yousif

Variational inference provides approximations to the computationally intractable posterior distribution in Bayesian networks. A prominent medical application of noisy-or Bayesian network is to infer potential diseases given observed…

Machine Learning · Computer Science 2016-05-23 Yusheng Xie , Nan Du , Wei Fan , Jing Zhai , Weicheng Zhu

Pattern detection and string matching are fundamental problems in computer science and the accelerated expansion of bioinformatics and computational biology have made them a core topic for both disciplines. The SARS-CoV-2 pandemic has made…

Genomics · Quantitative Biology 2025-05-14 Konstantinos Xylogiannopoulos

DNA read mapping is a ubiquitous task in bioinformatics, and many tools have been developed to solve the read mapping problem. However, there are two trends that are changing the landscape of readmapping: First, new sequencing technologies…

Genomics · Quantitative Biology 2017-02-09 Jens Quedenfeld , Sven Rahmann

It is well known that anti-malware scanners depend on malware signatures to identify malware. However, even minor modifications to malware code structure results in a change in the malware signature thus enabling the variant to evade…

Cryptography and Security · Computer Science 2025-05-27 Ritwik Murali , C Shunmuga Velayutham

Vision Transformers (ViTs) have emerged as the state-of-the-art architecture in representation learning, leveraging self-attention mechanisms to excel in various tasks. ViTs split images into fixed-size patches, constraining them to a…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Aswathi Varma , Suprosanna Shit , Chinmay Prabhakar , Daniel Scholz , Hongwei Bran Li , Bjoern Menze , Daniel Rueckert , Benedikt Wiestler

SARS-CoV-2 is an upper respiratory system RNA virus that has caused over 3 million deaths and infecting over 150 million worldwide as of May 2021. With thousands of strains sequenced to date, SARS-CoV-2 mutations pose significant challenges…

Quantitative Methods · Quantitative Biology 2021-11-15 Yanyi Ding , Zhiyi Kuang , Yuxin Pei , Jeff Tan , Ziyu Zhang , Joseph Konan

Online scanners analyze user-submitted files with a large number of security tools and provide access to the analysis results. As the most popular online scanner, VirusTotal (VT) is often used for determining if samples are malicious,…

Cryptography and Security · Computer Science 2022-11-01 Kevin van Liebergen , Juan Caballero , Platon Kotzias , Chris Gates

We propose a Vision-Language Transformer (VLT) framework for referring segmentation to facilitate deep interactions among multi-modal information and enhance the holistic understanding to vision-language features. There are different ways…

Computer Vision and Pattern Recognition · Computer Science 2022-11-28 Henghui Ding , Chang Liu , Suchen Wang , Xudong Jiang

Variation graphs, which represent genetic variation within a population, are replacing sequences as reference genomes. Path indexes are one of the most important tools for working with variation graphs. They generalize text indexes to…

Data Structures and Algorithms · Computer Science 2017-01-13 Jouni Sirén

The accurate identification of antiviral peptides (AVPs) is crucial for novel drug development. However, existing methods still have limitations in capturing complex sequence dependencies and distinguishing confusing samples with high…

Machine Learning · Computer Science 2026-01-19 Xinru Wen , Weizhong Lin , zi liu , Xuan Xiao