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Biological structure and function depend on complex regulatory interactions between many genes. A wealth of gene expression data is available from high-throughput genome-wide measurement technologies, but effective gene regulatory network…

Molecular Networks · Quantitative Biology 2016-03-28 Arwen Vanice Bradley , Ye Henry Li , Bokyung Choi , Wing Hung Wong

Large language models (LLMs) often suffer from hallucination, generating factually incorrect statements when handling questions beyond their knowledge and perception. Retrieval-augmented generation (RAG) addresses this by retrieving…

Computation and Language · Computer Science 2025-11-18 Shengyuan Chen , Chuang Zhou , Zheng Yuan , Qinggang Zhang , Zeyang Cui , Hao Chen , Yilin Xiao , Jiannong Cao , Xiao Huang

Large Vision-Language Models (LVLMs) exhibit strong multimodal capabilities but remain vulnerable to hallucinations from intrinsic errors and adversarial attacks from external exploitations, limiting their reliability in real-world…

Computer Vision and Pattern Recognition · Computer Science 2026-05-20 Chung-En Johnny Yu , Brian Jalaian , Nathaniel D. Bastian

Analytical reasoning is an essential and challenging task that requires a system to analyze a scenario involving a set of particular circumstances and perform reasoning over it to make conclusions. In this paper, we study the challenge of…

Computation and Language · Computer Science 2021-04-16 Wanjun Zhong , Siyuan Wang , Duyu Tang , Zenan Xu , Daya Guo , Jiahai Wang , Jian Yin , Ming Zhou , Nan Duan

Memory-Augmented Generation (MAG) extends Large Language Models with external memory to support long-context reasoning, but existing approaches largely rely on semantic similarity over monolithic memory stores, entangling temporal, causal,…

Artificial Intelligence · Computer Science 2026-04-17 Dongming Jiang , Yi Li , Guanpeng Li , Bingzhe Li

Visual Question Answering systems face reliability issues due to hallucinations, where models generate answers misaligned with visual input or factual knowledge. While Retrieval Augmented Generation frameworks mitigate this issue by…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ruoshuang Du , Xin Sun , Qiang Liu , Bowen Song , Zhongqi Chen , Weiqiang Wang , Liang Wang

Association Rule Mining (ARM) aims to discover patterns between features in datasets in the form of propositional rules, supporting both knowledge discovery and interpretable machine learning in high-stakes decision-making. However, in…

Machine Learning · Computer Science 2026-01-06 Erkan Karabulut , Daniel Daza , Paul Groth , Victoria Degeler

Procedural activity assistants potentially support humans in a variety of settings, from our daily lives, e.g., cooking or assembling flat-pack furniture, to professional situations, e.g., manufacturing or biological experiments. Despite…

Computation and Language · Computer Science 2025-10-02 Kimihiro Hasegawa , Wiradee Imrattanatrai , Masaki Asada , Ken Fukuda , Teruko Mitamura

We present Athena-PRM, a multimodal process reward model (PRM) designed to evaluate the reward score for each step in solving complex reasoning problems. Developing high-performance PRMs typically demands significant time and financial…

Machine Learning · Computer Science 2026-05-27 Shuai Wang , Zhenhua Liu , Jiaheng Wei , Xuanwu Yin , Dong Li , Emad Barsoum

Recent advances in large language models (LLMs) have opened new avenues for multimodal reasoning. Yet, most existing methods still rely on pretrained vision-language models (VLMs) to encode image-text pairs in isolation, ignoring the…

Computer Vision and Pattern Recognition · Computer Science 2026-03-27 Yuanfu Sun , Kang Li , Pengkang Guo , Jiajin Liu , Qiaoyu Tan

Large Language Models (LLMs) have achieved significant success in complex reasoning but remain bottlenecked by reliance on expert-annotated data and external verifiers. While existing self-evolution paradigms aim to bypass these…

Computation and Language · Computer Science 2026-02-05 Zhitao Gao , Jie Ma , Xuhong Li , Pengyu Li , Ning Qu , Yaqiang Wu , Hui Liu , Jun Liu

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we…

Machine Learning · Computer Science 2023-04-26 Payam Dibaeinia , Saurabh Sinha

Two-stage adaptive robust optimization (ARO) is a powerful approach for planning under uncertainty, balancing first-stage decisions with recourse decisions made after uncertainty is realized. To account for uncertainty, modelers typically…

Systems and Control · Electrical Eng. & Systems 2025-04-10 Aron Brenner , Rahman Khorramfar , Jennifer Sun , Saurabh Amin

Chromosome analysis is vital for diagnosing genetic disorders and guiding cancer therapy decisions through the identification of somatic clonal aberrations. However, developing an AI model are hindered by the overwhelming complexity and…

Quantitative Methods · Quantitative Biology 2025-05-23 Changchun Yang , Weiqian Dai , Yilan Zhang , Siyuan Chen , Jingdong Hu , Junkai Su , Yuxuan Chen , Ao Xu , Na Li , Xin Gao , Yongguo Yu

Complex visual reasoning and question answering (VQA) is a challenging task that requires compositional multi-step processing and higher-level reasoning capabilities beyond the immediate recognition and localization of objects and events.…

Machine Learning · Computer Science 2024-11-22 Shantanu Jaiswal , Debaditya Roy , Basura Fernando , Cheston Tan

Videos offer rich audiovisual information that can support people in performing activities of daily living (ADLs), but they remain largely inaccessible to blind or low-vision (BLV) individuals. In cooking, BLV people often rely on…

Human-Computer Interaction · Computer Science 2025-07-16 Zheng Ning , Leyang Li , Daniel Killough , JooYoung Seo , Patrick Carrington , Yapeng Tian , Yuhang Zhao , Franklin Mingzhe Li , Toby Jia-Jun Li

Existing automated attack suites operate as static ensembles with fixed sequences, lacking strategic adaptation and semantic awareness. This paper introduces the Agentic Reasoning for Methods Orchestration and Reparameterization (ARMOR)…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Gabriel Lee Jun Rong , Christos Korgialas , Dion Jia Xu Ho , Pai Chet Ng , Xiaoxiao Miao , Konstantinos N. Plataniotis

The ability to organically reason over and with both text and images is a pillar of human intelligence, yet the ability of Multimodal Large Language Models (MLLMs) to perform such multimodal reasoning remains under-explored. Existing…

Computer Vision and Pattern Recognition · Computer Science 2025-01-10 Yunzhuo Hao , Jiawei Gu , Huichen Will Wang , Linjie Li , Zhengyuan Yang , Lijuan Wang , Yu Cheng

Recent advances in Vision-Language Models (VLMs) have demonstrated impressive capabilities in perception and reasoning. However, the ability to perform causal inference -- a core aspect of human cognition -- remains underexplored,…

Computation and Language · Computer Science 2025-08-14 Keummin Ka , Junhyeong Park , Jaehyun Jeon , Youngjae Yu

The BioModels database is one of the premier databases for computational models in systems biology. The database contains over 1000 curated models and an even larger number of non-curated models. All the models are stored in the…

Molecular Networks · Quantitative Biology 2026-02-02 Bhavyahshree Navaneetha Krishnan , Adel Heydarabadipour , Herbert Sauro
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