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Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

Ultrasound localization microscopy offers new radiation-free diagnostic tools for vascular imaging deep within the tissue. Sequential localization of echoes returned from inert microbubbles with low-concentration within the bloodstream…

Medical Physics · Physics 2018-04-11 Oren Solomon , Ruud J. G. van Sloun , Hessel Wijkstra , Massimo Mischi , Yonina C. Eldar

Super-resolution is the process of obtaining a high-resolution image from one or more low-resolution images. Single image super-resolution (SISR) and multi-frame super-resolution (MFSR) methods have been evolved almost independently for…

Computer Vision and Pattern Recognition · Computer Science 2023-03-07 Mohammad Mahdi Afrasiabi , Reshad Hosseini , Aliazam Abbasfar

Deep learning-based image processing algorithms, including image super-resolution methods, have been proposed with significant improvement in performance in recent years. However, their implementations and evaluations are dispersed in terms…

Image and Video Processing · Electrical Eng. & Systems 2020-06-03 Jun-Ho Choi , Jun-Hyuk Kim , Jong-Seok Lee

This paper showcases the theoretical and numerical performance of the Sliding Frank-Wolfe, which is a novel optimization algorithm to solve the BLASSO sparse spikes super-resolution problem. The BLASSO is a continuous (i.e. off-the-grid or…

Numerical Analysis · Mathematics 2018-11-16 Quentin Denoyelle , Vincent Duval , Gabriel Peyré , Emmanuel Soubies

Particle filtering is a recursive Bayesian estimation technique that has gained popularity recently for tracking and localization applications. It uses Monte Carlo simulation and has proven to be a very reliable technique to model…

Robotics · Computer Science 2020-10-23 Adithya Krishna , André van Schaik , Chetan Singh Thakur

Recent developments in image acquisition literature have miniaturized the confocal laser endomicroscopes to improve usability and flexibility of the apparatus in actual clinical settings. However, miniaturized devices collect less light and…

Image and Video Processing · Electrical Eng. & Systems 2019-07-24 Saeed Izadi , Darren Sutton , Ghassan Hamarneh

In this study, we investigate the inverse source problem arising in bioluminescence tomography, the objective of which is to reconstruct both the support and the intensity of an internal light source from boundary measurements governed by…

Numerical Analysis · Mathematics 2025-11-25 Qianqian Wu , Rongfang Gong , Wei Gong , Ziyi Zhang , Shengfeng Zhu

Single-shot volumetric fluorescence (SVF) imaging offers a significant advantage over traditional imaging methods that require scanning across multiple axial planes as it can capture biological processes with high temporal resolution. The…

Recently, super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) has received much attention. However, ULM relies on low concentrations of microbubbles in the blood vessels, ultimately resulting in long…

Plenoptic cameras offer a cost effective solution to capture light fields by multiplexing multiple views on a single image sensor. However, the high angular resolution is achieved at the expense of reducing the spatial resolution of each…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Reuben A. Farrugia , C. Guillemot

Single particle reconstruction has recently emerged in 3D fluorescence microscopy as a powerful technique to improve the axial resolution and the degree of fluorescent labeling. It is based on the reconstruction of an average volume of a…

Image and Video Processing · Electrical Eng. & Systems 2023-01-24 Thibaut Eloy , Etienne Baudrier , Marine Laporte , Virginie Hamel , Paul Guichard , Denis Fortun

Confocal microscopy has long been a cornerstone technique for visualizing complex interactions and processes within cellular structures. However, achieving super-resolution imaging of multiple organelles and their interactions…

Optics · Physics 2025-08-19 Qinglin Chen , Luwei Wang , Jia Li , Dan Shao , Xiaoyu Weng , Liwei Liu , Dayong Jin , Junle Qu

Existing object localization methods are tailored to locate specific classes of objects, relying heavily on abundant labeled data for model optimization. However, acquiring large amounts of labeled data is challenging in many real-world…

Computer Vision and Pattern Recognition · Computer Science 2024-06-06 Yunhan Ren , Bo Li , Chengyang Zhang , Yong Zhang , Baocai Yin

Sound source localization (SSL) is a critical technology for determining the position of sound sources in complex environments. However, existing methods face challenges such as high computational costs and precise calibration requirements,…

Sound · Computer Science 2025-05-28 Yiyuan Yang , Shitong Xu , Niki Trigoni , Andrew Markham

We consider simultaneously identifying the membership and locations of point sources that are convolved with different band-limited point spread functions, from the observation of their superpositions. This problem arises in…

Information Theory · Computer Science 2017-03-22 Yuanxin Li , Yuejie Chi

Fluorescence imaging is an essential diagnostic tool in many fields, but diffraction-limited optical imaging at depth is limited by scattering. Here, we present a method based on multiple random illuminations, combined with a computational…

Optics · Physics 2026-03-30 Lei Zhu , Tengfei Wu , Bernhard Rauer , Hilton B. de Aguiar , Sylvain Gigan

Holographic displays promise several benefits including high quality 3D imagery, accurate accommodation cues, and compact form-factors. However, holography relies on coherent illumination which can create undesirable speckle noise in the…

Graphics · Computer Science 2023-09-20 Grace Kuo , Florian Schiffers , Douglas Lanman , Oliver Cossairt , Nathan Matsuda

The ability to resolve detail in the object that is being imaged, named by resolution, is the core parameter of an imaging system. Super-resolution is a class of techniques that can enhance the resolution of an imaging system and even…

Data Structures and Algorithms · Computer Science 2022-10-13 Yaonan Jin , Daogao Liu , Zhao Song

Localization microscopy is an imaging technique in which the positions of individual nanoscale point emitters (e.g. fluorescent molecules) are determined at high precision from their images. This is the key ingredient in…

Image and Video Processing · Electrical Eng. & Systems 2020-10-01 Elias Nehme , Daniel Freedman , Racheli Gordon , Boris Ferdman , Lucien E. Weiss , Onit Alalouf , Reut Orange , Tomer Michaeli , Yoav Shechtman
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