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Dormancy is an essential strategy for microorganisms to cope with environmental stress. However, global ecosystem models typically ignore microbial dormancy, resulting in major model uncertainties. To facilitate the consideration of…

Quantitative Methods · Quantitative Biology 2014-02-20 Gangsheng Wang , Melanie A. Mayes , Lianhong Gu , Christopher W. Schadt

In this paper, we present a neuro-inspired approach to reservoir computing (RC) in which a network of in vitro cultured cortical neurons serves as the physical reservoir. Rather than relying on artificial recurrent models to approximate…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Luca Ciampi , Ludovico Iannello , Fabrizio Tonelli , Gabriele Lagani , Angelo Di Garbo , Federico Cremisi , Giuseppe Amato

The heterogeneity of reaction fluxes present in a metabolic network within a single flux state can be exploited to construct the so-called backbone as a reduced version of metabolism. The backbone maintains all significant fluxes producing…

Molecular Networks · Quantitative Biology 2016-02-23 Oriol Güell , Francesc Sagués , M. Ángeles Serrano

We study the transport of bacteria in a porous media modeled by a square channel containing one cylindrical obstacle via molecular dynamics simulations coupled to a lattice Boltzmann fluid. Our bacteria model is a rod-shaped rigid body…

Soft Condensed Matter · Physics 2020-11-30 Miru Lee , Christoph Lohrmann , Kai Szuttor , Harold Auradou , Christian Holm

Personalized models of the gut microbiome are valuable for disease prevention and treatment. For this, one requires a mathematical model that predicts microbial community composition and the emergent behavior of microbial communities. We…

Populations and Evolution · Quantitative Biology 2019-10-29 James D. Brunner , Nicholas Chia

Bacteria can spontaneously develop collective motions by aligning their motions in dense systems. Here, we show that bacteria can also respond collectively to an alternating electrical field and form dynamic clusters oscillating at the same…

Soft Condensed Matter · Physics 2022-10-11 Mei Mei Bao , Isaiah Eze Igwe , Kang Chen , Tian Hui Zhang

Microbial communities display extreme diversity. A variety of strains or species coexist even when limited by a single resource. It has been argued that metabolite secretion creates new niches and facilitates such diversity. Nonetheless, it…

Populations and Evolution · Quantitative Biology 2020-02-05 Jumpei F Yamagishi , Nen Saito , Kunihiko Kaneko

Bacterial growth models are commonly used for the prediction of microbial safety and the shelf life of perishable foods. Growth is affected by several environmental factors such as temperature, acidity level and salt concentration. In this…

Applications · Statistics 2014-11-24 A. Paula Palacios , J. Miguel Marín , Emiliano J. Quinto , Michael P. Wiper

DNA and other biopolymers are being investigated as new computing substrates and alternative to silicon-based digital computers. However, the established top-down design of biomolecular interaction networks remains challenging and does not…

Soft Condensed Matter · Physics 2025-11-19 Tanmay Pandey , Petro Feketa , Jan Steinkühler

This is supplementary information for arXiv:1204.4896, which also appeared in Physical Biology 9, 026008 (2012). Main text abstract: Evolutionary experiments with microbes are a powerful tool to study mutations and natural selection. These…

Populations and Evolution · Quantitative Biology 2012-05-01 Kirill S Korolev , Melanie J I Müller , Nilay Karahan , Andrew W Murray , Oskar Hallatschek , David R Nelson

Physical reservoir computing is a computational framework that offers an energy- and computation-efficient alternative to conventional training of neural networks. In reservoir computing, input signals are mapped into the high-dimensional…

Soft Condensed Matter · Physics 2026-01-12 Veit-Lorenz Heuthe , Lukas Seemann , Samuel Tovey , Clemens Bechinger

We study the propagation and distribution of information-carrying signals injected in dynamical systems serving as a reservoir computers. A multivariate correlation analysis in tailored replica tests reveals consistency spectra and…

Disordered Systems and Neural Networks · Physics 2021-05-31 Thomas Jüngling , Thomas Lymburn , Michael Small

This study harnesses the embodied intelligence of mechanical metamaterials to sense and process environmental vibrations with minimal digital computation. Using physical reservoir computing (PRC), we turn the metamaterial and its nonlinear…

Emerging Technologies · Computer Science 2026-05-20 Shan He , Steven Kiyabu , Philip R. Buskohl , Patrick Musgrave

Cell cultures exhibit rich and complex behaviors driven by dynamic metabolic interactions among cells. In this work, we present a model that captures these interactions through a framework inspired by statistical mechanics. Using Monte…

Biological Physics · Physics 2025-09-25 A. R. Batista-Tomás , C. Díaz-Faloh , R. Mulet

Machine learning has become a fundamental approach for modeling, prediction, and control, enabling systems to learn from data and perform complex tasks. Reservoir computing is a machine learning tool that leverages high-dimensional…

Systems and Control · Electrical Eng. & Systems 2026-05-12 Sahand Tangerami , Nicholas A. Mecholsky , Francesco Sorrentino

Reservoir Computing is a machine learning approach that uses the rich repertoire of complex system dynamics for function approximation. Current approaches to reservoir computing use a network of coupled integrating neurons that require a…

Neural and Evolutionary Computing · Computer Science 2025-07-30 Alexander Yeung , Peter DelMastro , Arjun Karuvally , Hava Siegelmann , Edward Rietman , Hananel Hazan

A computational revolution unleashed the power of artificial neural networks. At the heart of that revolution is automatic differentiation, which calculates the derivative of a performance measure relative to a large number of parameters.…

Quantitative Methods · Quantitative Biology 2023-12-27 Steven A. Frank

Resistive switches are a class of emerging nanoelectronics devices that exhibit a wide variety of switching characteristics closely resembling behaviors of biological synapses. Assembled into random networks, such resistive switches produce…

Emerging Technologies · Computer Science 2015-07-15 Jens Burger , Alireza Goudarzi , Darko Stefanovic , Christof Teuscher

Predictive modelling is vital to guide preventive efforts. Whilst large-scale prospective cohort studies and a diverse toolkit of available machine learning (ML) algorithms have facilitated such survival task efforts, choosing the…

Numerous studies have shown that microbial metabolites, which represent the products of bacteria in the human gut, play a key role in shaping cancer risk and response to treatment. However, metabolite data typically contain a large…

Applications · Statistics 2026-05-19 Kai Jiang , Satabdi Saha , Christine B. Peterson
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