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Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet unsolved question is how resistance evolution affects cell growth at different drug levels. Here we develop a fitness model that predicts growth rates of…

Populations and Evolution · Quantitative Biology 2020-07-03 Fernanda Pinheiro , Omar Warsi , Dan I. Andersson , Michael Lässig

Metabolic models condense biochemical knowledge about organisms in a structured and standardised way. As large-scale network reconstructions are readily available for many organisms, genome-scale models are being widely used among modellers…

Molecular Networks · Quantitative Biology 2025-10-15 Marco Corrao , Hai He , Wolfram Liebermeister , Elad Noor , Arren Bar-Even

Plants rarely occur in isolated systems. Bacteria can inhabit either the endosphere, the region inside the plant root, or the rhizosphere, the soil region just outside the plant root. Our goal is to understand if using genomic data and…

Genomics · Quantitative Biology 2017-01-13 Jennifer Chien , Peter Larsen

We present a model for a biological reactor in which bacteria tend to aggregate in flocs, as encountered in wastewater treatment plants. The influence of this flocculation on the growth dynamics of the bacteria is studied. We argue that a…

Populations and Evolution · Quantitative Biology 2007-05-23 Bart Haegeman , Claude Lobry , Jerome Harmand

A fundamental challenge in microbial ecology is determining whether bacteria compete or cooperate in different environmental conditions. With recent advances in genome-scale metabolic models, we are now capable of simulating interactions…

Quantitative Methods · Quantitative Biology 2025-09-03 Oleksandr Cherendichenko , Josephine Solowiej-Wedderburn , Laura M. Carroll , Eric Libby

Radical shifts in the genetic composition of large cell populations are rare events with quite low probabilities, which direct numerical simulations generally fail to evaluate accurately. In this paper, we develop a theoretical large…

Probability · Mathematics 2024-09-16 Robert Azencott , Brett Geiger , Ilya Timofeyev

Biological networks have evolved to be highly functional within uncertain environments while remaining extremely adaptable. One of the main contributors to the robustness and evolvability of biological networks is believed to be their…

Molecular Networks · Quantitative Biology 2008-02-14 Arend Hintze , Christoph Adami

Computers are deterministic dynamical systems (CHAOS 19:033124, 2009). Among other things, that implies that one should be able to use deterministic forecast rules to predict their behavior. That statement is sometimes-but not always-true.…

Chaotic Dynamics · Physics 2013-05-24 Joshua Garland , Ryan James , Elizabeth Bradley

Reservoir computing is a popular approach to design recurrent neural networks, due to its training simplicity and approximation performance. The recurrent part of these networks is not trained (e.g., via gradient descent), making them…

Neural and Evolutionary Computing · Computer Science 2021-02-15 Pietro Verzelli , Cesare Alippi , Lorenzo Livi , Peter Tino

Microbial communities are ubiquitous in nature and come in a multitude of forms, ranging from communities dominated by a handful of species to communities containing a wide variety of metabolically distinct organisms. This huge range in…

Biological Physics · Physics 2021-11-02 Amir Erez , Jaime G. Lopez , Yigal Meir , Ned S. Wingreen

In nature, microorganisms must often cope with hostile environmental conditions. To do so they have developed sophisticated cooperative behavior and intricate communication capabilities, such as: direct cell-cell physical interactions via…

Condensed Matter · Physics 2007-05-23 Eshel Ben-Jacob , Inon Cohen , Ido Golding , Yonathan Kozlovsky

Devices based on arrays of interconnected magnetic nano-rings with emergent magnetization dynamics have recently been proposed for use in reservoir computing applications, but for them to be computationally useful it must be possible to…

Reservoir computing (RC) is a computational framework known for its training efficiency, making it ideal for physical hardware implementations. However, realizing the complex interconnectivity of traditional reservoirs in physical systems…

Machine Learning · Computer Science 2026-04-14 Smita Deb , Shirin Panahi , Mulugeta Haile , Ying-Cheng Lai

Reservoir computing is a recently introduced brain-inspired machine learning paradigm capable of excellent performances in the processing of empirical data. We focus in a particular kind of time-delay based reservoir computers that have…

Dynamical Systems · Mathematics 2014-11-11 Lyudmila Grigoryeva , Julie Henriques , Laurent Larger , Juan-Pablo Ortega

Biological systems are governed by coupled interactions between intracellular metabolism and bioreactor operation that span multiple time scales. Constraint-based metabolic models are widely used to describe intracellular metabolism, but…

Quantitative Methods · Quantitative Biology 2026-03-30 Peter E. Carstensen , Teddy Groves , Lars K. Nielsen , Ulrich Krühne , Krist V. Gernaey , John B. Jørgensen

A minimal model for reservoir computing is studied. We demonstrate that a reservoir computer exists that emulates given coupled maps by constructing a modularized network. We describe a possible mechanism for collapses of the emulation in…

Adaptation and Self-Organizing Systems · Physics 2024-05-15 Yuzuru Sato , Miki Kobayashi

Reservoir Computing is an emerging machine learning framework which is a versatile option for utilising physical systems for computation. In this paper, we demonstrate how a single node reservoir, made of a simple electronic circuit, can be…

Machine Learning · Computer Science 2022-12-23 N. Rasha Shanaz , K. Murali , P. Muruganandam

Reservoir computers, based on large recurrent neural networks with fixed random connections, are known to perform a wide range of information processing tasks. However, the nature of data transformations within the reservoir, the interplay…

Neural and Evolutionary Computing · Computer Science 2025-11-24 Claus Metzner , Achim Schilling , Thomas Kinfe , Andreas Maier , Patrick Krauss

Transformer architectures have recently surged as promising solutions for nonlinear dynamical systems, proposed as foundation models capable of zero-shot dynamics reconstruction and forecasting. Despite this success, it remains unclear…

Chaotic Dynamics · Physics 2026-05-06 Zheng-Meng Zhai , Celso Grebogi , Ying-Cheng Lai

Non-equilibrium molecular-scale dynamics, where fast electron transport couples with slow chemical state evolution, underpins the complex behaviors of molecular memristors, yet a general model linking these dynamics to neuromorphic…

Chemical Physics · Physics 2026-05-19 Yueqi Chen , Xuan Ji , Xi Yu
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