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In digital pathology, many image analysis tasks are challenged by the need for large and time-consuming manual data annotations to cope with various sources of variability in the image domain. Unsupervised domain adaptation based on…

Image and Video Processing · Electrical Eng. & Systems 2022-05-18 Nassim Bouteldja , Barbara Mara Klinkhammer , Tarek Schlaich , Peter Boor , Dorit Merhof

Semantic segmentation under domain shift remains a fundamental challenge in computer vision, particularly when labelled training data is scarce. This challenge is particularly exemplified in histopathology image analysis, where the same…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Zeeshan Nisar , Friedrich Feuerhake , Thomas Lampert

The variation in histologic staining between different medical centers is one of the most profound challenges in the field of computer-aided diagnosis. The appearance disparity of pathological whole slide images causes algorithms to become…

Image and Video Processing · Electrical Eng. & Systems 2024-04-05 Martin J. Hetz , Tabea-Clara Bucher , Titus J. Brinker

Unsupervised and unpaired domain translation using generative adversarial neural networks, and more precisely CycleGAN, is state of the art for the stain translation of histopathology images. It often, however, suffers from the presence of…

Computer Vision and Pattern Recognition · Computer Science 2022-07-04 Nicolas Brieu , Felix J. Segerer , Ansh Kapil , Philipp Wortmann , Guenter Schmidt

Virtual stain transfer is a promising area of research in Computational Pathology, which has a great potential to alleviate important limitations when applying deeplearningbased solutions such as lack of annotations and sensitivity to a…

Computer Vision and Pattern Recognition · Computer Science 2022-10-19 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert

Digitized Histological diagnosis is in increasing demand. However, color variations due to various factors are imposing obstacles to the diagnosis process. The problem of stain color variations is a well-defined problem with many proposed…

Computer Vision and Pattern Recognition · Computer Science 2018-04-06 M Tarek Shaban , Christoph Baur , Nassir Navab , Shadi Albarqouni

In whole slide imaging, commonly used staining techniques based on hematoxylin and eosin (H&E) and immunohistochemistry (IHC) stains accentuate different aspects of the tissue landscape. In the case of detecting metastases, IHC provides a…

Image and Video Processing · Electrical Eng. & Systems 2022-08-30 Joseph Boyd , Irène Villa , Marie-Christine Mathieu , Eric Deutsch , Nikos Paragios , Maria Vakalopoulou , Stergios Christodoulidis

Automatic segmentation of white matter hyperintensities in magnetic resonance images is of paramount clinical and research importance. Quantification of these lesions serve as a predictor for risk of stroke, dementia and mortality. During…

Image and Video Processing · Electrical Eng. & Systems 2020-09-11 Julian Alberto Palladino , Diego Fernandez Slezak , Enzo Ferrante

This work proves that semantic segmentation on minimally invasive surgical instruments can be improved by using training data that has been augmented through domain adaptation. The benefit of this method is twofold. Firstly, it suppresses…

Computer Vision and Pattern Recognition · Computer Science 2020-06-08 Iñigo Azqueta-Gavaldon , Florian Fröhlich , Klaus Strobl , Rudolph Triebel

Computational histopathology image diagnosis becomes increasingly popular and important, where images are segmented or classified for disease diagnosis by computers. While pathologists do not struggle with color variations in slides,…

Image and Video Processing · Electrical Eng. & Systems 2020-07-27 Hanwen Liang , Konstantinos N. Plataniotis , Xingyu Li

Domain Adaptation is a technique to address the lack of massive amounts of labeled data in unseen environments. Unsupervised domain adaptation is proposed to adapt a model to new modalities using solely labeled source data and unlabeled…

Computer Vision and Pattern Recognition · Computer Science 2021-11-19 Thong Vo , Naimul Khan

Domain adaptation is of huge interest as labeling is an expensive and error-prone task, especially when labels are needed on pixel-level like in semantic segmentation. Therefore, one would like to be able to train neural networks on…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Annika Mütze , Matthias Rottmann , Hanno Gottschalk

Generalization is one of the main challenges of computational pathology. Slide preparation heterogeneity and the diversity of scanners lead to poor model performance when used on data from medical centers not seen during training. In order…

Image and Video Processing · Electrical Eng. & Systems 2024-01-09 Nicolas Nerrienet , Rémy Peyret , Marie Sockeel , Stéphane Sockeel

In recent years, semantic segmentation has taken benefit from various works in computer vision. Inspired by the very versatile CycleGAN architecture, we combine semantic segmentation with the concept of cycle consistency to enable a…

Computer Vision and Pattern Recognition · Computer Science 2022-01-19 Jonas Löhdefink , Tim Fingscheidt

Digital pathology has made significant advances in tumor diagnosis and segmentation, but image variability due to differences in organs, tissue preparation, and acquisition - known as domain shift - limits the effectiveness of current…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Ho Heon Kim , Won Chan Jeong , Young Shin Ko , Young Jin Park

With the FDA approval of Artificial Intelligence (AI) for point-of-care clinical diagnoses, model generalizability is of the utmost importance as clinical decision-making must be domain-agnostic. A method of tackling the problem is to…

Image and Video Processing · Electrical Eng. & Systems 2021-07-07 Ricky Chen , Timothy T. Yu , Gavin Xu , Da Ma , Marinko V. Sarunic , Mirza Faisal Beg

Background and objectives. Domain shift is a generalisation problem of machine learning models that occurs when the data distribution of the training set is different to the data distribution encountered by the model when it is deployed.…

Computer Vision and Pattern Recognition · Computer Science 2022-07-28 Manuel García-Domínguez , César Domínguez , Jónathan Heras , Eloy Mata , Vico Pascual

Lightweight deep learning models offer substantial reductions in computational cost and environmental impact, making them crucial for scientific applications. We present a lightweight CycleGAN for modality transfer in fluorescence…

Computer Vision and Pattern Recognition · Computer Science 2025-10-20 Mohammad Soltaninezhad , Yashar Rouzbahani , Jhonatan Contreras , Rohan Chippalkatti , Daniel Kwaku Abankwa , Christian Eggeling , Thomas Bocklitz

Magnetic Resonance Imaging (MRI) scans acquired from different scanners or institutions often suffer from domain shifts owing to variations in hardware, protocols, and acquisition parameters. This discrepancy degrades the performance of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Mohd Usama , Belal Ahmad , Faleh Menawer R Althiyabi

The application of supervised deep learning methods in digital pathology is limited due to their sensitivity to domain shift. Digital Pathology is an area prone to high variability due to many sources, including the common practice of…

Image and Video Processing · Electrical Eng. & Systems 2020-12-24 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert
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