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Medical image denoising is considered among the most challenging vision tasks. Despite the real-world implications, existing denoising methods have notable drawbacks as they often generate visual artifacts when applied to heterogeneous…

Image and Video Processing · Electrical Eng. & Systems 2025-03-11 S M A Sharif , Rizwan Ali Naqvi , Woong-Kee Loh

Nowadays, modern electron microscopes deliver images at atomic scale. The precise atomic structure encodes information about material properties. Thus, an important ingredient in the image analysis is to locate the centers of the atoms…

Computer Vision and Pattern Recognition · Computer Science 2017-09-13 Benjamin Berkels , Benedikt Wirth

Objective: Electrocardiogram (ECG) signals commonly suffer noise interference, such as baseline wander. High-quality and high-fidelity reconstruction of the ECG signals is of great significance to diagnosing cardiovascular diseases.…

Signal Processing · Electrical Eng. & Systems 2023-01-19 Huayu Li , Gregory Ditzler , Janet Roveda , Ao Li

Scanning acoustic microscopy (SAM) has been employed since microscopic images are widely used for biomedical or materials research. Acoustic imaging is an important and well-established method used in nondestructive testing (NDT),…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Shubham Kumar Gupta , Azeem Ahmad , Prakhar Kumar , Frank Melandso , Anowarul Habib

Cryo-electron tomography enables 3D visualization of cells in a near native state at molecular resolution. The produced cellular tomograms contain detailed information about all macromolecular complexes, their structures, their abundances…

Quantitative Methods · Quantitative Biology 2019-04-30 Min Xu , Elitza I Tocheva , Yi-Wei Chang , Grant J Jensen , Frank Alber

Computed tomography is widely used as an imaging tool to visualize three-dimensional structures with expressive bone-soft tissue contrast. However, CT resolution and radiation dose are tightly entangled, highlighting the importance of…

We present a geometry-aware method for heterogeneous single-particle cryogenic electron microscopy (cryo-EM) reconstruction that predicts atomic backbone conformations. To incorporate protein-structure priors, we represent the backbone as a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Jonathan Krook , Axel Janson , Joakim Andén , Melanie Weber , Ozan Öktem

Although defocus can be used to generate partial phase contrast in transmission electron microscope images, cryo-electron microscopy (cryo-EM) can be further improved by the development of phase plates which increase contrast by applying a…

Quantitative Methods · Quantitative Biology 2024-03-14 Jeremy J. Axelrod , Jessie T. Zhang , Petar N. Petrov , Robert M. Glaeser , Holger Mueller

Deep-learning (DL)-based methods have shown significant promise in denoising myocardial perfusion SPECT images acquired at low dose. For clinical application of these methods, evaluation on clinical tasks is crucial. Typically, these…

Image and Video Processing · Electrical Eng. & Systems 2023-03-02 Md Ashequr Rahman , Zitong Yu , Barry A. Siegel , Abhinav K. Jha

The scanning electron microscope (SEM) produces an image of a sample by scanning it with a focused beam of electrons. The electrons interact with the atoms in the sample, which emit secondary electrons that contain information about the…

Computer Vision and Pattern Recognition · Computer Science 2017-09-08 Shahar Tsiper , Or Dicker , Idan Kaizerman , Zeev Zohar , Mordechai Segev , Yonina C. Eldar

Long lasting efforts have been made to reduce radiation dose and thus the potential radiation risk to the patient for computed tomography acquisitions without severe deterioration of image quality. To this end, numerous reconstruction and…

Medical Physics · Physics 2024-10-07 Elias Eulig , Björn Ommer , Marc Kachelrieß

Point cloud denoising task aims to recover the clean point cloud from the scanned data coupled with different levels or patterns of noise. The recent state-of-the-art methods often train deep neural networks to update the point locations…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Zhaonan Wang , Manyi Li , ShiQing Xin , Changhe Tu

Message passing algorithms have been tailored for compressive imaging applications by plugging in different types of off-the-shelf image denoisers. These off-the-shelf denoisers mostly rely on some generic or hand-crafted priors for…

Image and Video Processing · Electrical Eng. & Systems 2025-12-16 Chang Cai , Xiaojun Yuan , Ying-Jun Angela Zhang

We present a novel method for training score-based generative models which uses nonlinear noising dynamics to improve learning of structured distributions. Generalizing to a nonlinear drift allows for additional structure to be incorporated…

Machine Learning · Statistics 2025-07-10 Jeremiah Birrell , Markos A. Katsoulakis , Luc Rey-Bellet , Benjamin J. Zhang , Wei Zhu

One of the difficulties in 3D reconstruction of molecules from images in single particle Cryo-Electron Microscopy (Cryo-EM), in addition to high levels of noise and unknown image orientations, is heterogeneity in samples: in many cases, the…

Computer Vision and Pattern Recognition · Computer Science 2016-07-13 Roy R. Lederman , Amit Singer

Magnetic resonance imaging (MRI) is a powerful noninvasive diagnostic imaging tool that provides unparalleled soft tissue contrast and anatomical detail. Noise contamination, especially in accelerated and/or low-field acquisitions, can…

Image and Video Processing · Electrical Eng. & Systems 2025-05-12 Jiachen Tu , Yaokun Shi , Fan Lam

The CryoEM single particle imaging method has recently received broad attention in the field of structural biology for determining the structures of biological molecules. The structures can be resolved to near-atomic resolutions after…

Biomolecules · Quantitative Biology 2017-12-27 Yihua Wang , Daqi Yu , Qi Ouyang , Haiguang Liu

Structural dynamics of macromolecules is critical to their structural-function relationship. Cryogenic electron microscopy (CryoEM) provides snapshots of vitrified protein at different compositional and conformational states, and the…

Quantitative Methods · Quantitative Biology 2026-01-27 Muyuan Chen , Muchen Li , Renjie Liao

Biomedical images are noisy. The imaging equipment itself has physical limitations, and the consequent experimental trade-offs between signal-to-noise ratio, acquisition speed, and imaging depth exacerbate the problem. Denoising is,…

Image and Video Processing · Electrical Eng. & Systems 2020-11-11 Mikhail Papkov , Kenny Roberts , Lee Ann Madissoon , Omer Bayraktar , Dmytro Fishman , Kaupo Palo , Leopold Parts

While adversarial training is considered as a standard defense method against adversarial attacks for image classifiers, adversarial purification, which purifies attacked images into clean images with a standalone purification model, has…

Machine Learning · Computer Science 2021-06-14 Jongmin Yoon , Sung Ju Hwang , Juho Lee