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Large vision foundation models have been widely adopted for retinal disease classification without systematic evidence justifying their parameter requirements. In the present work we address two critical questions: First, are large…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 David Isztl , Tahm Spitznagel , Gabor Mark Somfai , Rui Santos

Longitudinal imaging is able to capture both static anatomical structures and dynamic changes in disease progression toward earlier and better patient-specific pathology management. However, conventional approaches rarely take advantage of…

Predictive uncertainty-a model's self awareness regarding its accuracy on an input-is key for both building robust models via training interventions and for test-time applications such as selective classification. We propose a novel…

Machine Learning · Computer Science 2024-01-04 Nishant Jain , Karthikeyan Shanmugam , Pradeep Shenoy

This study proposes a retinal prosthetic simulation framework driven by visual fixations, inspired by the saccade mechanism, and assesses performance improvements through end-to-end optimization in a classification task. Salient patches are…

Computer Vision and Pattern Recognition · Computer Science 2026-02-23 Yuli Wu , Do Dinh Tan Nguyen , Henning Konermann , Rüveyda Yilmaz , Peter Walter , Johannes Stegmaier

Inference-time sparsification is a promising path to deploy large language models (LLMs) on resource-constrained devices, yet existing training-free methods typically estimate feedforward network (FFN) neuron importance from the input…

Supervised fine-tuning (SFT) is fundamental to adapting large language models, yet training on complete datasets incurs prohibitive costs with diminishing returns. Existing data selection methods suffer from severe domain specificity:…

Computation and Language · Computer Science 2026-02-02 Junyou Su , He Zhu , Xiao Luo , Liyu Zhang , Hong-Yu Zhou , Yun Chen , Peng Li , Yang Liu , Guanhua Chen

Diabetic retinopathy (DR), a microvascular complication of diabetes and a leading cause of preventable blindness, is projected to affect more than 130 million individuals worldwide by 2030. Early identification is essential to reduce…

Quantitative Methods · Quantitative Biology 2025-11-12 Jophy Lin

Aligning structured data is a fundamental problem in computer vision and machine learning, underlying tasks such as time series analysis, human action recognition, and visual representation learning. Existing alignment methods, including…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Lei Wang , Syuan-Hao Li , Yongsheng Gao , Piotr Koniusz

Deep neural networks (DNNs) have achieved remarkable empirical success, yet their training dynamics remain understood mainly from optimization rather than statistical principles. Here we develop a statistical framework for DNN training in…

Machine Learning · Statistics 2026-05-28 Minhao Yao , Ruoyu Wang , Xihong Lin , Lin Liu , Zhonghua Liu

In this work, we present a novel application of an uncertainty-quantification framework called Deep Evidential Learning in the domain of radiotherapy dose prediction. Using medical images of the Open Knowledge-Based Planning Challenge…

Machine Learning · Computer Science 2024-09-24 Hai Siong Tan , Kuancheng Wang , Rafe Mcbeth

Direct evaluation of LLMs on benchmarks can be misleading because comparatively strong performance may reflect task familiarity rather than capability. The train-before-test approach controls for task familiarity by giving each model…

Machine Learning · Computer Science 2026-03-16 Kun Wang , Reinhard Heckel

Retinopathy represents a group of retinal diseases that, if not treated timely, can cause severe visual impairments or even blindness. Many researchers have developed autonomous systems to recognize retinopathy via fundus and optical…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Taimur Hassan , Bilal Hassan , Muhammad Usman Akram , Shahrukh Hashmi , Abdel Hakim Taguri , Naoufel Werghi

Prognostic models aim to predict the future course of a disease or condition and are a vital component of personalized medicine. Statistical models make use of longitudinal data to capture the temporal aspect of disease progression;…

Machine Learning · Computer Science 2020-07-13 Joshua Bridge , Simon P. Harding , Yalin Zheng

Early identification of stroke is crucial for intervention, requiring reliable models. We proposed an efficient retinal image representation together with clinical information to capture a comprehensive overview of cardiovascular health,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-11 Yuqing Huang , Bastian Wittmann , Olga Demler , Bjoern Menze , Neda Davoudi

This paper tackles the challenging problem of estimating the intensity of Facial Action Units with few labeled images. Contrary to previous works, our method does not require to manually select key frames, and produces state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2020-11-05 Enrique Sanchez , Adrian Bulat , Anestis Zaganidis , Georgios Tzimiropoulos

There is an increasing number of medical use-cases where classification algorithms based on deep neural networks reach performance levels that are competitive with human medical experts. To alleviate the challenges of small dataset sizes,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-28 Vignesh Srinivasan , Nils Strodthoff , Jackie Ma , Alexander Binder , Klaus-Robert Müller , Wojciech Samek

Functional data is a powerful tool for capturing and analyzing complex patterns and relationships in a variety of fields, allowing for more precise modeling, visualization, and decision-making. For example, in healthcare, functional data…

Methodology · Statistics 2023-04-26 Xiyuan Gao , Jiayi Wang , Guanyu Hu , Jianguo Sun

Retinal blood vessel segmentation can extract clinically relevant information from fundus images. As manual tracing is cumbersome, algorithms based on Convolution Neural Networks have been developed. Such studies have used small publicly…

Image and Video Processing · Electrical Eng. & Systems 2024-06-24 Jeremiah Fadugba , Patrick Köhler , Lisa Koch , Petru Manescu , Philipp Berens

Challenges in the field of retinal prostheses motivate the development of retinal models to accurately simulate Retinal Ganglion Cells (RGCs) responses. The goal of retinal prostheses is to enable blind individuals to solve complex,…

Image and Video Processing · Electrical Eng. & Systems 2022-02-08 Nikolas Papadopoulos , Nikos Melanitis , Antonio Lozano , Cristina Soto-Sanchez , Eduardo Fernandez , Konstantina S Nikita

Clinical time-series learning is routinely constrained by small, heterogeneous cohorts and protocol drift, while its downstream use spans both classification (e.g., pathology diagnosis) and regression (e.g., temporal forecasting). These…

Machine Learning · Computer Science 2026-05-29 Sharmita Dey , Diego Paez-Granados
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