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Multimodal imaging has transformed neuroscience research. While it presents unprecedented opportunities, it also imposes serious challenges. Particularly, it is difficult to combine the merits of the interpretability attributed to a simple…

Methodology · Statistics 2021-11-25 Xiaowu Dai , Lexin Li

Reliability in Neural Networks (NNs) is crucial in safety-critical applications like healthcare, and uncertainty estimation is a widely researched method to highlight the confidence of NNs in deployment. In this work, we propose an…

Machine Learning · Computer Science 2020-11-20 Utkarsh Sarawgi , Wazeer Zulfikar , Rishab Khincha , Pattie Maes

Limited DXA access hinders osteoporosis screening. This proof-of-concept study proposes using widely available knee X-rays for opportunistic Bone Mineral Density (BMD) estimation via deep learning, emphasizing robust uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Long Hui , Wai Lok Yeung

Knee osteoarthritis (KOA) is a prevalent musculoskeletal disorder, often diagnosed using X-rays due to its cost-effectiveness. While Magnetic Resonance Imaging (MRI) provides superior soft tissue visualization and serves as a valuable…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Zhe Wang , Yung Hsin Chen , Aladine Chetouani , Fabian Bauer , Yuhua Ru , Fang Chen , Liping Zhang , Rachid Jennane , Mohamed Jarraya

This proof-of-concept study introduces a novel multimodal framework combining synchronized EEG-fNIRS modalities with neuronal avalanche analysis to identify early network dysfunction in Alzheimer's disease. The approach leverages…

Neurons and Cognition · Quantitative Biology 2026-03-25 Eva Guttmann-Flury , Yun-Hsuan Chen , Qiaoyuan Xiang , Hao Zhang , Mohamad Sawan

Predicting stroke risk is a complex challenge that can be enhanced by integrating diverse clinically available data modalities. This study introduces a self-supervised multimodal framework that combines 3D brain imaging, clinical data, and…

Computer Vision and Pattern Recognition · Computer Science 2025-07-09 Camille Delgrange , Olga Demler , Samia Mora , Bjoern Menze , Ezequiel de la Rosa , Neda Davoudi

This paper considers making active learning more sensible from a medical perspective. In practice, a disease manifests itself in different forms across patient cohorts. Existing frameworks have primarily used mathematical constructs to…

Image and Video Processing · Electrical Eng. & Systems 2022-06-28 Yash-yee Logan , Ryan Benkert , Ahmad Mustafa , Gukyeong Kwon , Ghassan AlRegib

Normative modelling is an emerging method for understanding the underlying heterogeneity within brain disorders like Alzheimer Disease (AD) by quantifying how each patient deviates from the expected normative pattern that has been learned…

Image and Video Processing · Electrical Eng. & Systems 2026-02-06 Sayantan Kumar , Philip Payne , Aristeidis Sotiras

We propose a deep neural architecture that performs uncertainty-aware multi-view classification of arrhythmia from ECG. Our method learns two different views (1D and 2D) of single-lead ECG to capture different types of information. We use a…

Signal Processing · Electrical Eng. & Systems 2025-06-10 Mohd Ashhad , Sana Rahmani , Mohammed Fayiz , Ali Etemad , Javad Hashemi

Musculoskeletal and neurological disorders are the most common causes of walking problems among older people, and they often lead to diminished quality of life. Analyzing walking motion data manually requires trained professionals and the…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Manli Zhu , Qianhui Men , Edmond S. L. Ho , Howard Leung , Hubert P. H. Shum

Alzheimer's disease and Frontotemporal dementia are common forms of neurodegenerative dementia. Behavioral alterations and cognitive impairments are found in the clinical courses of both diseases and their differential diagnosis is…

Image and Video Processing · Electrical Eng. & Systems 2023-09-12 Huy-Dung Nguyen , Michaël Clément , Vincent Planche , Boris Mansencal , Pierrick Coupé

Early detection of neurodegenerative disorders is an important open problem, since early diagnosis and treatment may yield a better prognosis. Researchers have recently sought to leverage advances in machine learning algorithms to detect…

Machine Learning · Computer Science 2024-09-23 Abhishek Jaiswal , Nisheeth Srivastava

Knee osteoarthritis (OA) is very common progressive and degenerative musculoskeletal disease worldwide creates a heavy burden on patients with reduced quality of life and also on society due to financial impact. Therefore, any attempt to…

Image and Video Processing · Electrical Eng. & Systems 2020-05-26 Neslihan Bayramoglu , Miika T. Nieminen , Simo Saarakkala

Purpose: To organize a knee MRI segmentation challenge for characterizing the semantic and clinical efficacy of automatic segmentation methods relevant for monitoring osteoarthritis progression. Methods: A dataset partition consisting of 3D…

This study evaluates a multimodal machine learning framework for predicting treatment outcomes in intracranial aneurysms (IAs). Combining angiographic parametric imaging (API), patient biomarkers, and disease morphology, the framework aims…

In open data sets of functional magnetic resonance imaging (fMRI), the heterogeneity of the data is typically attributed to a combination of factors, including differences in scanning procedures, the presence of confounding effects, and…

Machine Learning · Computer Science 2026-04-17 Xin Wen , Shijie Guo , Wenbo Ning , Rui Cao , Yan Niu , Bin Wan , Peng Wei , Xiaobo Liu , Jie Xiang

The integrity of articular cartilage is a crucial aspect in the early diagnosis of osteoarthritis (OA). Many novel MRI techniques have the potential to assess compositional changes of the cartilage extracellular matrix. Among these…

Computer Vision and Pattern Recognition · Computer Science 2019-12-05 Alejandra Duarte , Chaitra V. Hegde , Aakash Kaku , Sreyas Mohan , José G. Raya

Knee osteoarthritis (OA) is the most common osteoarthritis and a leading cause of disability. Cartilage defects are regarded as major manifestations of knee OA, which are visible by magnetic resonance imaging (MRI). Thus early detection and…

Image and Video Processing · Electrical Eng. & Systems 2022-01-13 Zixu Zhuang , Liping Si , Sheng Wang , Kai Xuan , Xi Ouyang , Yiqiang Zhan , Zhong Xue , Lichi Zhang , Dinggang Shen , Weiwu Yao , Qian Wang

Conventional imaging diagnostics frequently encounter bottlenecks due to manual inspection, which can lead to delays and inconsistencies. Although deep learning offers a pathway to automation and enhanced accuracy, foundational models in…

Computer Vision and Pattern Recognition · Computer Science 2024-03-18 Aymen Sekhri , Marouane Tliba , Mohamed Amine Kerkouri , Yassine Nasser , Aladine Chetouani , Alessandro Bruno , Rachid Jennane

Deep neural networks have been widely studied for predicting a medical condition, such as total knee replacement (TKR). It has shown that data of different modalities, such as imaging data, clinical variables and demographic information,…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Xinwen Liu , Jing Wang , S. Kevin Zhou , Craig Engstrom , Shekhar S. Chandra