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Generating synthetic tabular health data is challenging, and evaluating their quality is equally, if not more, complex. This systematic review highlights the critical importance of rigorous evaluation of synthetic health data to ensure…

Machine Learning · Computer Science 2026-05-15 Nazia Nafis , Inaki Esnaola , Alvaro Martinez-Perez , Maria-Cruz Villa-Uriol , Venet Osmani

Generative models have been found effective for data synthesis due to their ability to capture complex underlying data distributions. The quality of generated data from these models is commonly evaluated by visual inspection for image…

Machine Learning · Computer Science 2022-10-18 Emily Muller , Xu Zheng , Jer Hayes

Recent advances in deep generative models have greatly expanded the potential to create realistic synthetic health datasets. These synthetic datasets aim to preserve the characteristics, patterns, and overall scientific conclusions derived…

Machine Learning · Computer Science 2024-07-04 Jennifer A Bartell , Sander Boisen Valentin , Anders Krogh , Henning Langberg , Martin Bøgsted

Faced with the challenges of patient confidentiality and scientific reproducibility, research on machine learning for health is turning towards the conception of synthetic medical databases. This article presents a brief overview of…

Synthetic health data have the potential to mitigate privacy concerns when sharing data to support biomedical research and the development of innovative healthcare applications. Modern approaches for data generation based on machine…

Machine Learning · Computer Science 2023-01-11 Chao Yan , Yao Yan , Zhiyu Wan , Ziqi Zhang , Larsson Omberg , Justin Guinney , Sean D. Mooney , Bradley A. Malin

Synthetic data has emerged as a powerful resource in life sciences, offering solutions for data scarcity, privacy protection and accessibility constraints. By creating artificial datasets that mirror the characteristics of real data, allows…

Ensuring safe adoption of AI tools in healthcare hinges on access to sufficient data for training, testing and validation. In response to privacy concerns and regulatory requirements, using synthetic data has been suggested. Synthetic data…

Ensuring the generalisability of clinical machine learning (ML) models across diverse healthcare settings remains a significant challenge due to variability in patient demographics, disease prevalence, and institutional practices. Existing…

Machine Learning · Computer Science 2025-04-30 Bradley Segal , Joshua Fieggen , David Clifton , Lei Clifton

Synthetic tabular data generation has emerged as a promising method to address limited data availability and privacy concerns. With the sharp increase in the performance of large language models in recent years, researchers have been…

Machine Learning · Computer Science 2025-03-28 Reilly Cannon , Nicolette M. Laird , Caesar Vazquez , Andy Lin , Amy Wagler , Tony Chiang

Evaluating the quality of synthetic data remains a key challenge for ensuring privacy and utility in data-driven research. In this work, we present an evaluation framework that quantifies how well synthetic data replicates original…

Machine Learning · Computer Science 2025-04-03 Andrey Sidorenko , Michael Platzer , Mario Scriminaci , Paul Tiwald

Class imbalance can often degrade predictive performance of supervised learning algorithms. Balanced classes can be obtained by oversampling exact copies, with noise, or interpolation between nearest neighbours (as in traditional SMOTE…

Machine Learning · Computer Science 2022-01-17 Emily Muller , Xu Zheng , Jer Hayes

Tabular data is common yet typically incomplete, small in volume, and access-restricted due to privacy concerns. Synthetic data generation offers potential solutions. Many metrics exist for evaluating the quality of synthetic tabular data;…

Machine Learning · Computer Science 2024-04-01 Scott Cheng-Hsin Yang , Baxter Eaves , Michael Schmidt , Ken Swanson , Patrick Shafto

Data synthesis has been advocated as an important approach for utilizing data while protecting data privacy. In recent years, a plethora of tabular data synthesis algorithms (i.e., synthesizers) have been proposed. Some synthesizers satisfy…

Cryptography and Security · Computer Science 2025-09-09 Yuntao Du , Ninghui Li

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Since technology is advancing so quickly in the modern era of information, data is becoming an essential resource in many fields. Correct data collection, organization, and analysis make it a potent tool for successful decision-making,…

Machine Learning · Computer Science 2024-05-28 Dilsat Berin Aytar , Semra Gunduc

Healthcare research and development face significant obstacles due to data scarcity and stringent privacy regulations, such as HIPAA and the GDPR, restricting access to essential real-world medical data. These limitations impede innovation,…

Machine Learning · Computer Science 2025-10-17 Md Ibrahim Shikder Mahin , Md Shamsul Arefin , Md Tanvir Hasan

Synthetic data serves as an alternative in training machine learning models, particularly when real-world data is limited or inaccessible. However, ensuring that synthetic data mirrors the complex nuances of real-world data is a challenging…

Machine Learning · Computer Science 2023-10-27 Lasse Hansen , Nabeel Seedat , Mihaela van der Schaar , Andrija Petrovic

Tabular data is one of the most prevalent and important data formats in real-world applications such as healthcare, finance, and education. However, its effective use in machine learning is often constrained by data scarcity, privacy…

Machine Learning · Computer Science 2025-07-18 Ruxue Shi , Yili Wang , Mengnan Du , Xu Shen , Yi Chang , Xin Wang

The availability of genomic data is essential to progress in biomedical research, personalized medicine, etc. However, its extreme sensitivity makes it problematic, if not outright impossible, to publish or share it. As a result, several…

Genomics · Quantitative Biology 2022-01-19 Bristena Oprisanu , Georgi Ganev , Emiliano De Cristofaro

The rapid growth in data availability has facilitated research and development, yet not all industries have benefited equally due to legal and privacy constraints. The healthcare sector faces significant challenges in utilizing patient data…

Methodology · Statistics 2025-11-18 Katariina Perkonoja , Kari Auranen , Joni Virta
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