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Whole-slide images (WSIs) are an important data modality in computational pathology, yet their gigapixel resolution and lack of fine-grained annotations challenge conventional deep learning models. Multiple instance learning (MIL) offers a…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Qian Zeng , Yihui Wang , Shu Yang , Yingxue Xu , Fengtao Zhou , Jiabo Ma , Dejia Cai , Zhengyu Zhang , Lijuan Qu , Yu Wang , Li Liang , Hao Chen

In computational pathology, extracting spatial features from gigapixel whole slide images (WSIs) is a fundamental task, but due to their large size, WSIs are typically segmented into smaller tiles. A critical aspect of this analysis is…

Image and Video Processing · Electrical Eng. & Systems 2024-10-23 Ruiwen Ding , Kha-Dinh Luong , Erika Rodriguez , Ana Cristina Araujo Lemos da Silva , William Hsu

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with…

Image and Video Processing · Electrical Eng. & Systems 2026-03-23 Lubin Gan , Jing Zhang , Heng Zhang , Xin Di , Zhifeng Wang , Wenke Huang , Xiaoyan Sun

Recently, pathological diagnosis has achieved superior performance by combining deep learning models with the multiple instance learning (MIL) framework using whole slide images (WSIs). However, the giga-pixeled nature of WSIs poses a great…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Zijie Fang , Yifeng Wang , Ye Zhang , Zhi Wang , Jian Zhang , Xiangyang Ji , Yongbing Zhang

Efficiently modeling large 2D contexts is essential for various fields including Giga-Pixel Whole Slide Imaging (WSI) and remote sensing. Transformer-based models offer high parallelism but face challenges due to their quadratic complexity…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Jingwei Zhang , Anh Tien Nguyen , Xi Han , Vincent Quoc-Huy Trinh , Hong Qin , Dimitris Samaras , Mahdi S. Hosseini

Whole Slide Images (WSIs) in histopathology pose a significant challenge for extensive medical image analysis due to their ultra-high resolution, massive scale, and intricate spatial relationships. Although existing Multiple Instance…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Jiaxuan Lu , Yuhui Lin , Junyan Shi , Fang Yan , Dongzhan Zhou , Yue Gao , Xiaosong Wang

Histopathology plays a critical role in medical diagnostics, with whole slide images (WSIs) offering valuable insights that directly influence clinical decision-making. However, the large size and complexity of WSIs may pose significant…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Zhongwei Qiu , Hanqing Chao , Tiancheng Lin , Wanxing Chang , Zijiang Yang , Wenpei Jiao , Yixuan Shen , Yunshuo Zhang , Yelin Yang , Wenbin Liu , Hui Jiang , Yun Bian , Ke Yan , Dakai Jin , Le Lu

Advances in computational pathology increasingly rely on extracting meaningful representations from Whole Slide Images (WSIs) to support various clinical and biological tasks. In this study, we propose a generalizable deep learning…

Computer Vision and Pattern Recognition · Computer Science 2025-09-26 Shakib Khan , Fariba Dambandkhameneh , Nazim Shaikh , Yao Nie , Raghavan Venugopal , Xiao Li

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

The effectiveness and efficiency of modeling complex spectral-spatial relations are both crucial for Hyperspectral image (HSI) classification. Most existing methods based on CNNs and transformers still suffer from heavy computational…

Computer Vision and Pattern Recognition · Computer Science 2024-06-12 Jiamu Sheng , Jingyi Zhou , Jiong Wang , Peng Ye , Jiayuan Fan

Multiple Instance Learning (MIL) has emerged as a dominant paradigm to extract discriminative feature representations within Whole Slide Images (WSIs) in computational pathology. Despite driving notable progress, existing MIL approaches…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Shu Yang , Yihui Wang , Hao Chen

Survival analysis using whole-slide images (WSIs) is crucial in cancer research. Despite significant successes, pathology images typically only provide slide-level labels, which hinders the learning of discriminative representations from…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Chengsheng Zhang , Linhao Qu , Xiaoyu Liu , Zhijian Song

Computational pathology (CPath) has significantly advanced the clinical practice of pathology. Despite the progress made, Multiple Instance Learning (MIL), a promising paradigm within CPath, continues to face challenges, particularly…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Yuqi Zhang , Xiaoqian Zhang , Jiakai Wang , Yuancheng Yang , Taiying Peng , Chao Tong

Hyperspectral image (HSI) classification constitutes the fundamental research in remote sensing fields. Convolutional Neural Networks (CNNs) and Transformers have demonstrated impressive capability in capturing spectral-spatial contextual…

Computer Vision and Pattern Recognition · Computer Science 2024-08-09 Yan He , Bing Tu , Bo Liu , Jun Li , Antonio Plaza

Whole-slide image (WSI) analysis is challenging due to the gigapixel scale of slides and their inherent hierarchical multi-resolution structure. Existing multiple instance learning (MIL) approaches often model WSIs as unordered collections…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Dongqing Xie , Yonghuang Wu

Mamba, a State Space Model (SSM) that accelerates training by recasting recurrence as a parallel scan, has recently emerged as a linearly-scaling alternative to self-attention. Because of its unidirectional nature, each state in Mamba only…

Computer Vision and Pattern Recognition · Computer Science 2025-11-13 Jingwei Zhang , Xi Han , Hong Qin , Mahdi S. Hosseini , Dimitris Samaras

Mamba, a special case of the State Space Model, is gaining popularity as an alternative to template-based deep learning approaches in medical image analysis. While transformers are powerful architectures, they have drawbacks, including…

3D object detection is critical for autonomous driving, yet it remains fundamentally challenging to simultaneously maximize computational efficiency and capture long-range spatial dependencies. We observed that Mamba-based models, with…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Longhui Zheng , Qiming Xia , Xiaolu Chen , Zhaoliang Liu , Chenglu Wen

In the domain of 3D biomedical image segmentation, Mamba exhibits the superior performance for it addresses the limitations in modeling long-range dependencies inherent to CNNs and mitigates the abundant computational overhead associated…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Weitong Wu , Zhaohu Xing , Jing Gong , Qin Peng , Lei Zhu

Hyperspectral image (HSI) classification has been one of the hot topics in remote sensing fields. Recently, the Mamba architecture based on selective state-space models (S6) has demonstrated great advantages in long sequence modeling.…

Computer Vision and Pattern Recognition · Computer Science 2025-04-23 Hongxing Peng , Kang Lin , Huanai Liu
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