In the domain of 3D biomedical image segmentation, Mamba exhibits the superior performance for it addresses the limitations in modeling long-range dependencies inherent to CNNs and mitigates the abundant computational overhead associated with Transformer-based frameworks when processing high-resolution medical volumes. However, attaching undue importance to global context modeling may inadvertently compromise critical local structural information, thus leading to boundary ambiguity and regional distortion in segmentation outputs. Therefore, we propose the HybridMamba, an architecture employing dual complementary mechanisms: 1) a feature scanning strategy that progressively integrates representations both axial-traversal and local-adaptive pathways to harmonize the relationship between local and global representations, and 2) a gated module combining spatial-frequency analysis for comprehensive contextual modeling. Besides, we collect a multi-center CT dataset related to lung cancer. Experiments on MRI and CT datasets demonstrate that HybridMamba significantly outperforms the state-of-the-art methods in 3D medical image segmentation.
@article{arxiv.2509.14609,
title = {HybridMamba: A Dual-domain Mamba for 3D Medical Image Segmentation},
author = {Weitong Wu and Zhaohu Xing and Jing Gong and Qin Peng and Lei Zhu},
journal= {arXiv preprint arXiv:2509.14609},
year = {2025}
}