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Tuberculosis (TB) remains a global health threat, ranking among the leading causes of mortality worldwide. In this context, machine learning (ML) has emerged as a transformative force, providing innovative solutions to the complexities…

Neural Ordinary Differential Equations (NODEs) use a neural network to model the instantaneous rate of change in the state of a system. However, despite their apparent suitability for dynamics-governed time-series, NODEs present a few…

Machine Learning · Computer Science 2021-08-18 Alexander Norcliffe , Cristian Bodnar , Ben Day , Jacob Moss , Pietro Liò

Random networks with specified degree distributions have been proposed as realistic models of population structure, yet the problem of dynamically modeling SIR-type epidemics in random networks remains complex. I resolve this dilemma by…

Populations and Evolution · Quantitative Biology 2007-05-23 Erik Volz

We propose a learning method well-suited to infer the presence of Tuberculosis (TB) manifestations on Computer Tomography (CT) scans mimicking the radiologist reports. Latent features are extracted from the CT volumes employing the V-Net…

Image and Video Processing · Electrical Eng. & Systems 2019-07-30 Pedro M. Gordaliza , Juan José Vaquero , Sally Sharpe , Fergus Gleeson , Arrate Muñoz-Barrutia

Parkinson's disease (PD) shows heterogeneous, evolving brain-morphometry patterns. Modeling these longitudinal trajectories enables mechanistic insight, treatment development, and individualized 'digital-twin' forecasting. However, existing…

Machine Learning · Computer Science 2025-11-10 Xiaoda Wang , Yuji Zhao , Kaiqiao Han , Xiao Luo , Sanne van Rooij , Jennifer Stevens , Lifang He , Liang Zhan , Yizhou Sun , Wei Wang , Carl Yang

We propose a new model that describes the dynamics of epidemic spreading on connected graphs. Our model consists in a PDE-ODE system where at each vertex of the graph we have a standard SIR model and connexions between vertices are given by…

Analysis of PDEs · Mathematics 2020-11-25 Christophe Besse , Grégory Faye

Modeling dynamical systems is crucial across the science and engineering fields for accurate prediction, control, and decision-making. Recently, machine learning (ML) approaches, particularly neural ordinary differential equations (NODEs),…

Systems and Control · Electrical Eng. & Systems 2026-04-20 Fatima Al-Janahi , Min-Seung Ko , Hao Zhu

Mathematical models are traditionally used to analyze the long-term global evolution of epidemics, to determine the potential and severity of an outbreak, and to provide critical information for identifying the type of disease interventions…

Numerical Analysis · Mathematics 2020-04-28 Ognyan Kounchev , Georgi Simeonov , Zhana Kuncheva

Neural differential equations offer a powerful framework for modeling continuous-time dynamics, but forecasting stiff biophysical systems remains unreliable. Standard Neural ODEs and physics informed variants often require orders of…

Machine Learning · Computer Science 2025-11-18 Kamalpreet Singh Kainth , Prathamesh Dinesh Joshi , Raj Abhijit Dandekar , Rajat Dandekar , Sreedat Panat

Graph neural Ordinary Differential Equations (ODE) combine neural ODE with the message passing mechanism of Graph Neural Networks (GNN), providing a continuous-time modeling method for graph representation learning. However, in dynamic…

Machine Learning · Computer Science 2026-04-29 Xiaoyi Wang , Zhiqiang Wang , Jianqing Liang , Xingwang Zhao , Chuangyin Dang , Zhen Jin , Jiye Liang

Neural PDE solvers are increasingly used as learned surrogates for families of partial differential equations, where the key machine learning challenge is not only interpolation on a fixed benchmark distribution but generalization under…

Machine Learning · Computer Science 2026-05-26 Lennon Shikhman

Automated insulin delivery for Type 1 Diabetes must balance glucose control and safety under uncertain meals and physiological variability. While reinforcement learning (RL) enables adaptive personalization, existing approaches struggle to…

Machine Learning · Computer Science 2026-01-23 Yushen Liu , Yanfu Zhang , Xugui Zhou

This paper introduces a novel hybrid model combining Partial Differential Equations (PDEs) and Ordinary Differential Equations (ODEs) to simulate infectious disease dynamics across geographic regions. By leveraging the spatial detail of…

Dynamical Systems · Mathematics 2025-11-18 Kristina Kehrer , Martin Weiser , Tim Conrad

Tuberculosis (TB), an infectious bacterial disease, is a significant cause of death, especially in low-income countries, with an estimated ten million new cases reported globally in $2020$. While TB is treatable, non-adherence to the…

The duration, type and structure of connections between individuals in real-world populations play a crucial role in how diseases invade and spread. Here, we incorporate the aforementioned heterogeneities into a model by considering a…

Physics and Society · Physics 2018-04-05 Rosanna C Barnard , Istvan Z Kiss , Luc Berthouze , Joel C Miller

In most models of the spread of disease over contact networks it is assumed that the probabilities per unit time of disease transmission and recovery from disease are constant, implying exponential distributions of the time intervals for…

Physics and Society · Physics 2010-07-23 Brian Karrer , M. E. J. Newman

Tuberculosis (TB) is a major global health threat, causing millions of deaths annually. Although early diagnosis and treatment can greatly improve the chances of survival, it remains a major challenge, especially in developing countries.…

Computer Vision and Pattern Recognition · Computer Science 2023-12-06 Yun Liu , Yu-Huan Wu , Shi-Chen Zhang , Li Liu , Min Wu , Ming-Ming Cheng

The outbreaks of Coronavirus Disease 2019 (COVID-19) have impacted the world significantly. Modeling the trend of infection and real-time forecasting of cases can help decision making and control of the disease spread. However, data-driven…

Populations and Evolution · Quantitative Biology 2020-09-18 Zhijian Li , Yunling Zheng , Jack Xin , Guofa Zhou

Irregularly measured time series are common in many of the applied settings in which time series modelling is a key statistical tool, including medicine. This provides challenges in model choice, often necessitating imputation or similar…

Neural networks are one tool for approximating non-linear differential equations used in scientific computing tasks such as surrogate modeling, real-time predictions, and optimal control. PDE foundation models utilize neural networks to…

Machine Learning · Computer Science 2025-02-11 Elisa Negrini , Yuxuan Liu , Liu Yang , Stanley J. Osher , Hayden Schaeffer