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The study of the dynamics of chemical reactions, and in particular phenomena such as oscillating reactions, has led to the recognition that many dynamical properties of a chemical reaction can be predicted from graph theoretical properties…

Dynamical Systems · Mathematics 2022-11-08 J. J. P. Veerman , Tessa Whalen-Wagner , Ewan Kummel

The next generation of force fields for molecular dynamics will be developed using a wealth of data. Training systematically with experimental data remains a challenge, however, especially for machine learning potentials. Differentiable…

Biomolecules · Quantitative Biology 2025-04-16 Joe G Greener

The Turing completeness result for continuous chemical reaction networks (CRN) shows that any computable function over the real numbers can be computed by a CRN over a finite set of formal molecular species using at most bimolecular…

Quantitative Methods · Quantitative Biology 2021-07-01 Mathieu Hemery , François Fages , Sylvain Soliman

The accurate prediction of biological features from genomic data is paramount for precision medicine and sustainable agriculture. For decades, neural network models have been widely popular in fields like computer vision, astrophysics and…

Genomics · Quantitative Biology 2022-03-15 Zhaoyi Zhang , Songyang Cheng , Claudia Solis-Lemus

Neural networks (NNs) have emerged as a state-of-the-art method for modeling nonlinear systems in model predictive control (MPC). However, the robustness of NNs, in terms of sensitivity to small input perturbations, remains a critical…

Systems and Control · Electrical Eng. & Systems 2023-08-29 Wallace Tan Gian Yion , Zhe Wu

In a reversible language, any forward computation can be undone by a finite sequence of backward steps. Reversible computing has been studied in the context of different programming languages and formalisms, where it has been used for…

Programming Languages · Computer Science 2016-08-22 Naoki Nishida , Adrián Palacios , Germán Vidal

Retrosynthesis, of which the goal is to find a set of reactants for synthesizing a target product, is an emerging research area of deep learning. While the existing approaches have shown promising results, they currently lack the ability to…

Machine Learning · Computer Science 2021-06-04 Hankook Lee , Sungsoo Ahn , Seung-Woo Seo , You Young Song , Eunho Yang , Sung-Ju Hwang , Jinwoo Shin

Accurately predicting response properties of molecules such as the dynamic polarizability and hyperpolarizability using quantum mechanics has been a long-standing challenge with widespread applications in material and drug design. Classical…

Chemical Physics · Physics 2020-09-01 Xiaoxia Cai , Wei-Hai Fang , Heng Fan , Zhendong Li

Here we address the challenge of profiling causal properties and tracking the transformation of chemical compounds from an algorithmic perspective. We explore the potential of applying a computational interventional calculus based on the…

Molecular Networks · Quantitative Biology 2018-03-20 Hector Zenil , Narsis A. Kiani , Ming-Mei Shang , Jesper Tegnér

Convolutional neural networks (CNN) have been successful in machine learning applications. Their success relies on their ability to consider space invariant local features. We consider the use of CNN to fit nuisance models in semiparametric…

Machine Learning · Statistics 2025-09-08 Mohammad Ghasempour , Niloofar Moosavi , Xavier de Luna

Dynamical systems in biology are complex, and one often does not have comprehensive knowledge about the interactions involved. Chemical reaction network (CRN) inference aims to identify, from observing species concentrations over time, the…

Methodology · Statistics 2026-04-15 Yong See Foo , Adriana Zanca , Jennifer A. Flegg , Ivo Siekmann

The ability of a chemical reaction network to generate itself by catalyzed reactions from constantly present environmental food sources is considered a fundamental property in origin-of-life research. Based on Kaufmann's autocatalytic sets,…

Molecular Networks · Quantitative Biology 2023-08-16 Dimitri Loutchko

In this work we present an efficient and practically implementable approach for the application of reinforcement learning (RL)-based control in chemical process systems. This is an area that has yet to widely adopt RL-based control largely…

Systems and Control · Electrical Eng. & Systems 2026-05-21 Austin Braniff , Yuhe Tian

With the recent advances in machine learning for quantum chemistry, it is now possible to predict the chemical properties of compounds and to generate novel molecules. Existing generative models mostly use a string- or graph-based…

Biomolecules · Quantitative Biology 2020-10-14 Vitali Nesterov , Mario Wieser , Volker Roth

We mathematically prove that chemical reaction networks without hidden layers can solve tasks for which spiking neural networks require hidden layers. Our proof uses the deterministic mass-action kinetics formulation of chemical reaction…

Machine Learning · Computer Science 2026-03-13 Sophie Jaffard , Ivo F. Sbalzarini

We present a computational method for performing structural translation, which has been studied recently in the context of analyzing the steady states and dynamical behavior of mass-action systems derived from biochemical reaction networks.…

Optimization and Control · Mathematics 2018-08-29 Matthew D. Johnston , Evan Burton

In recent studies [1][13][12] Recurrent Neural Networks were used for generative processes and their surprising performance can be explained by their ability to create good predictions. In addition, data compression is also based on…

Computation and Language · Computer Science 2017-05-03 Juan Andrés Laura , Gabriel Masi , Luis Argerich

We identify the thermodynamic conditions necessary to observe indefinite growth in homogeneous open chemical reaction networks (CRNs) satisfying mass action kinetics. We also characterize the thermodynamic efficiency of growth by…

Molecular Networks · Quantitative Biology 2024-12-05 Shesha Gopal Marehalli Srinivas , Francesco Avanzini , Massimiliano Esposito

In both mobile and web applications, speeding up user interface response times can often lead to significant improvements in user engagement. A common technique to improve responsiveness is to precompute data ahead of time for specific…

Machine Learning · Computer Science 2020-03-04 Hanson Wang , Zehui Wang , Yuanyuan Ma

The difficult problem of relating the static structure of glassy liquids and their dynamics is a good target for Machine Learning, an approach which excels at finding complex patterns hidden in data. Indeed, this approach is currently a hot…

Soft Condensed Matter · Physics 2024-05-29 Francesco Saverio Pezzicoli , Guillaume Charpiat , François P. Landes
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