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In image restoration, single-step discriminative mappings often lack fine details via expectation learning, whereas generative paradigms suffer from inefficient multi-step sampling and noise-residual coupling. To address this dilemma, we…

Computer Vision and Pattern Recognition · Computer Science 2026-04-22 Zihao Fan , Xin Lu , Jie Xiao , Dong Li , Jie Huang , Xueyang Fu

Molecular generation and molecular property prediction are both crucial for drug discovery, but they are often developed independently. Inspired by recent studies, which demonstrate that diffusion model, a prominent generative approach, can…

Machine Learning · Computer Science 2025-04-07 Shikun Feng , Yuyan Ni , Yan Lu , Zhi-Ming Ma , Wei-Ying Ma , Yanyan Lan

Enzyme design is a critical area in biotechnology, with applications ranging from drug development to synthetic biology. Traditional methods for enzyme function prediction or protein binding pocket design often fall short in capturing the…

Machine Learning · Computer Science 2024-10-02 Chenqing Hua , Yong Liu , Dinghuai Zhang , Odin Zhang , Sitao Luan , Kevin K. Yang , Guy Wolf , Doina Precup , Shuangjia Zheng

Deep generative models offer a powerful alternative to conventional channel estimation by learning complex channel distributions. By integrating the rich environmental information available in modern sensing-aided networks, this paper…

Machine Learning · Computer Science 2026-03-17 Xiaotian Fan , Xingyu Zhou , Le Liang , Xiao Li , Shi Jin

Flow-based generative models have shown remarkable success in text-to-image generation, yet fine-tuning them with intermediate feedback remains challenging, especially for continuous-time flow matching models. Most existing approaches…

Machine Learning · Computer Science 2025-10-22 Jiajun Fan , Chaoran Cheng , Shuaike Shen , Xiangxin Zhou , Ge Liu

Finding a suitable layout represents a crucial task for diverse applications in graphic design. Motivated by simpler and smoother sampling trajectories, we explore the use of Flow Matching as an alternative to current diffusion-based layout…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Julian Jorge Andrade Guerreiro , Naoto Inoue , Kento Masui , Mayu Otani , Hideki Nakayama

Simulation-free methods for training continuous-time generative models construct probability paths that go between noise distributions and individual data samples. Recent works, such as Flow Matching, derived paths that are optimal for each…

MeanFlow offers a promising framework for one-step generative modeling by directly learning a mean-velocity field, bypassing expensive numerical integration. However, we find that the highly curved generative trajectories of existing models…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Xinxi Zhang , Shiwei Tan , Quang Nguyen , Quan Dao , Ligong Han , Xiaoxiao He , Tunyu Zhang , Chengzhi Mao , Dimitris Metaxas , Vladimir Pavlovic

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2018-01-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

Generative models can have distinct mode of failures like mode dropping and low quality samples, which cannot be captured by a single scalar metric. To address this, recent works propose evaluating generative models using precision and…

Machine Learning · Computer Science 2023-02-03 Alexandre Verine , Benjamin Negrevergne , Muni Sreenivas Pydi , Yann Chevaleyre

Flow based generative models have charted an impressive path across multiple visual generation tasks by adhering to a simple principle: learning velocity representations of a linear interpolant. However, we observe that training velocity…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Inkyu Shin , Chenglin Yang , Liang-Chieh Chen

Deep generative models such as diffusion and flow matching are powerful machine learning tools capable of learning and sampling from high-dimensional distributions. They are particularly useful when the training data appears to be…

High Energy Physics - Phenomenology · Physics 2026-04-30 Zachary Bogorad , Ibrahim Elsharkawy , Yonatan Kahn , Andrew J. Larkoski , Noam Levi

Flow matching models have emerged as a powerful method for generative modeling on domains like images or videos, and even on irregular or unstructured data like 3D point clouds or even protein structures. These models are commonly trained…

Machine Learning · Computer Science 2025-05-30 Yuyang Wang , Anurag Ranjan , Josh Susskind , Miguel Angel Bautista

New technologies such as Rectified Flow and Flow Matching have significantly improved the performance of generative models in the past two years, especially in terms of control accuracy, generation quality, and generation efficiency.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-09 Sen Fang , Hongbin Zhong , Yalin Feng , Yanxin Zhang , Dimitris N. Metaxas

Predicting transcriptional responses to genetic perturbations is a central problem in functional genomics. In practice, perturbation responses are rarely gene-independent but instead manifest as coordinated, program-level transcriptional…

Genomics · Quantitative Biology 2026-02-06 Jiafa Ruan , Ruijie Quan , Zongxin Yang , Liyang Xu , Yi Yang

Modeling transformations between arbitrary data distributions is a fundamental scientific challenge, arising in applications like drug discovery and evolutionary simulation. While flow matching offers a natural framework for this task, its…

Machine Learning · Computer Science 2025-10-09 Shiye Su , Yuhui Zhang , Linqi Zhou , Rajesh Ranganath , Serena Yeung-Levy

High-quality power flow datasets are essential for training machine learning models in power systems. However, security and privacy concerns restrict access to real-world data, making statistically accurate and physically consistent…

Machine Learning · Computer Science 2025-08-26 Milad Hoseinpour , Vladimir Dvorkin

Flow matching has emerged as a promising framework for training generative models, demonstrating impressive empirical performance while offering relative ease of training compared to diffusion-based models. However, this method still…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Quan Dao , Hao Phung , Trung Dao , Dimitris Metaxas , Anh Tran

Regional hydrology studies are often supported by high resolution simulations of subsurface flow that require expensive and extensive computations. Efficient usage of the latest high performance parallel computing systems becomes a…

Mathematical Software · Computer Science 2017-10-04 Carsten Burstedde , Jose A. Fonseca , Stefan Kollet

The accurate prediction of small scales in underresolved flows is still one of the main challenges in predictive simulations of complex configurations. Over the last few years, data-driven modeling has become popular in many fields as…

Fluid Dynamics · Physics 2022-10-31 Mathis Bode