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Accurate image registration is essential in many medical imaging applications, yet most deep registration networks provide little indication of when or where their predictions are unreliable. Existing uncertainty estimation approaches, such…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Lin Tian , Xiaoling Hu , Juan Eugenio Iglesias

Measuring uncertainties in the output of a deep learning method is useful in several ways, such as in assisting with interpretation of the outputs, helping build confidence with end users, and for improving the training and performance of…

Machine Learning · Computer Science 2022-09-20 Luke Whitbread , Mark Jenkinson

In the last decade, research on artificial intelligence has seen rapid growth with deep learning models, especially in the field of medical image segmentation. Various studies demonstrated that these models have powerful prediction…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Dominik Müller , Iñaki Soto-Rey , Frank Kramer

In the field of semi-supervised medical image segmentation, the shortage of labeled data is the fundamental problem. How to effectively learn image features from unlabeled images to improve segmentation accuracy is the main research…

Computer Vision and Pattern Recognition · Computer Science 2023-10-11 Zhanhong Qiu , Haitao Gan , Ming Shi , Zhongwei Huang , Zhi Yang

Medical image segmentation has advanced rapidly over the past two decades, largely driven by deep learning, which has enabled accurate and efficient delineation of cells, tissues, organs, and pathologies across diverse imaging modalities.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-29 Guoping Xu , Jayaram K. Udupa , Jax Luo , Songlin Zhao , Yajun Yu , Scott B. Raymond , Hao Peng , Lipeng Ning , Yogesh Rathi , Wei Liu , You Zhang

Deep neural networks are increasingly being used for the analysis of medical images. However, most works neglect the uncertainty in the model's prediction. We propose an uncertainty-aware deep kernel learning model which permits the…

Machine Learning · Computer Science 2021-06-11 Zhiliang Wu , Yinchong Yang , Jindong Gu , Volker Tresp

Each year, numerous segmentation and classification algorithms are invented or reused to solve problems where machine vision is needed. Generally, the efficiency of these algorithms is compared against the results given by one or many human…

Computer Vision and Pattern Recognition · Computer Science 2008-12-18 Arnaud Martin , Hicham Laanaya , Andreas Arnold-Bos

In the domain of medical imaging, many supervised learning based methods for segmentation face several challenges such as high variability in annotations from multiple experts, paucity of labelled data and class imbalanced datasets. These…

Computer Vision and Pattern Recognition · Computer Science 2025-05-15 Soumick Chatterjee , Franziska Gaidzik , Alessandro Sciarra , Hendrik Mattern , Gábor Janiga , Oliver Speck , Andreas Nürnberger , Sahani Pathiraja

We propose a new optimization framework for aleatoric uncertainty estimation in regression problems. Existing methods can quantify the error in the target estimation, but they tend to underestimate it. To obtain the predictive uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2021-03-12 Takumi Kawashima , Qing Yu , Akari Asai , Daiki Ikami , Kiyoharu Aizawa

Objective: Accurate probability estimates are essential for the safe deployment of medical image segmentation models in clinical decision-making. However, modern deep segmentation networks are often poorly calibrated, a problem exacerbated…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Meritxell Riera-Marín , Javier García López , Júlia Rodríguez-Comas , Miguel A. González Ballester , Adrian Galdran

Organ segmentation in CT volumes is an important pre-processing step in many computer assisted intervention and diagnosis methods. In recent years, convolutional neural networks have dominated the state of the art in this task. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-12-08 Roger D. Soberanis-Mukul , Nassir Navab , Shadi Albarqouni

Equipping predicted segmentation with calibrated uncertainty is essential for safety-critical applications. In this work, we focus on capturing the data-inherent uncertainty (aka aleatoric uncertainty) in segmentation, typically when…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Zhitong Gao , Yucong Chen , Chuyu Zhang , Xuming He

Medical Image Foundation Models have proven to be powerful tools for mask prediction across various datasets. However, accurately assessing the uncertainty of their predictions remains a significant challenge. To address this, we propose a…

Image and Video Processing · Electrical Eng. & Systems 2025-01-20 Xin Wang , Xiaoyu Liu , Peng Huang , Pu Huang , Shu Hu , Hongtu Zhu

Transfer learning is a critical technique in training deep neural networks for the challenging medical image segmentation task that requires enormous resources. With the abundance of medical image data, many research institutions release…

Computer Vision and Pattern Recognition · Computer Science 2023-07-25 Yuncheng Yang , Meng Wei , Junjun He , Jie Yang , Jin Ye , Yun Gu

Image segmentation is often performed on medical images for identifying diseases in clinical evaluation. Hence it has become one of the major research areas. Conventional image segmentation techniques are unable to provide satisfactory…

Computer Vision and Pattern Recognition · Computer Science 2017-02-13 Pratik Kalshetti , Manas Bundele , Parag Rahangdale , Dinesh Jangra , Chiranjoy Chattopadhyay , Gaurav Harit , Abhay Elhence

Over recent years, deep learning based image registration has achieved impressive accuracy in many domains, including medical imaging and, specifically, human neuroimaging with magnetic resonance imaging (MRI). However, the uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Xiaoling Hu , Karthik Gopinath , Peirong Liu , Malte Hoffmann , Koen Van Leemput , Oula Puonti , Juan Eugenio Iglesias

Foundation models for segmentation such as the Segment Anything Model (SAM) family exhibit strong zero-shot performance, but remain vulnerable in shifted or limited-knowledge domains. This work investigates whether uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Jesse Brouwers , Xiaoyan Xing , Alexander Timans

Organ segmentation in CT volumes is an important pre-processing step in many computer assisted intervention and diagnosis methods. In recent years, convolutional neural networks have dominated the state of the art in this task. However,…

Image and Video Processing · Electrical Eng. & Systems 2020-08-25 Roger D. Soberanis-Mukul , Nassir Navab , Shadi Albarqouni

Based on the Denoising Diffusion Probabilistic Model (DDPM), medical image segmentation can be described as a conditional image generation task, which allows to compute pixel-wise uncertainty maps of the segmentation and allows an implicit…

Image and Video Processing · Electrical Eng. & Systems 2022-11-01 Xutao Guo , Yanwu Yang , Chenfei Ye , Shang Lu , Yang Xiang , Ting Ma

Despite the remarkable progress in generative modelling, current diffusion models lack a quantitative approach to assess image quality. To address this limitation, we propose to estimate the pixel-wise aleatoric uncertainty during the…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Michele De Vita , Vasileios Belagiannis