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There is widespread optimism that frontier Large Language Models (LLMs) and LLM-augmented systems have the potential to rapidly accelerate scientific discovery across disciplines. Today, many benchmarks exist to measure LLM knowledge and…

Retrieval-Augmented Generation (RAG) offers a promising solution to address various limitations of Large Language Models (LLMs), such as hallucination and difficulties in keeping up with real-time updates. This approach is particularly…

Randomized experiments or randomized controlled trials (RCTs) are gold standards for causal inference, yet cost and sample-size constraints limit power. We introduce CALM (Causal Analysis leveraging Language Models), a statistical framework…

The recent paradigm shift toward large reasoning models (LRMs) as autonomous agents has intensified the demand for sophisticated, multi-turn tool-use capabilities. Yet, existing datasets and data-generation approaches are limited by static,…

This paper investigates whether Large Language Models (LLMs), fine-tuned on synthetic but domain-representative data, can perform the twofold task of (i) slot and intent detection and (ii) natural language response generation for a smart…

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Today, large language models (LLMs) are taught to use new tools by providing a few demonstrations of the tool's usage. Unfortunately, demonstrations are hard to acquire, and can result in undesirable biased usage if the wrong demonstration…

Large Language Models (LLMs) exhibit a unique phenomenon known as emergent abilities, demonstrating adeptness across numerous tasks, from text summarization to code generation. While these abilities open up novel avenues in software design…

Recent advancements in single-cell multi-omics, particularly RNA-seq, have provided profound insights into cellular heterogeneity and gene regulation. While pre-trained language model (PLM) paradigm based single-cell foundation models have…

We propose eXtensible Prompt (X-Prompt) for prompting a large language model (LLM) beyond natural language (NL). X-Prompt instructs an LLM with not only NL but also an extensible vocabulary of imaginary words. Registering new imaginary…

Clinical reasoning agents based on large language models (LLMs) aim to automate tasks such as intensive care unit (ICU) monitoring and patient state tracking from electronic health records (EHRs). Existing systems typically rely on manually…

Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction. Radiation oncology is particularly well suited for LLM…

Recent advancements in large language models (LLMs) have exhibited promising performance in solving sequential decision-making problems. By imitating few-shot examples provided in the prompts (i.e., in-context learning), an LLM agent can…

Human-robot collaboration in industrial settings requires precise and reliable communication to enhance operational efficiency. While Large Language Models (LLMs) understand general language, they often lack the domain-specific rigidity…

Retrieval-Augmented Generation (RAG) has emerged as a key paradigm for enhancing large language models (LLMs) by incorporating external knowledge. However, current RAG methods face two limitations: (1) they only cover limited RAG scenarios.…

Retrieval-augmented generation (RAG) with large language models (LLMs) is especially valuable in specialized domains, where precision is critical. To more specialize the LLMs into a target domain, domain-specific RAG has recently been…

Large Language Models (LLMs) excel in data synthesis but can be inaccurate in domain-specific tasks, which retrieval-augmented generation (RAG) systems address by leveraging user-provided data. However, RAGs require optimization in both…

Training large language models (LLMs) with synthetic reasoning data has become a popular approach to enhancing their reasoning capabilities, while a key factor influencing the effectiveness of this paradigm is the quality of the generated…

Although DNA foundation models have advanced the understanding of genomes, they still face significant challenges in the limited scale and diversity of genomic data. This limitation starkly contrasts with the success of natural language…

Large language models (LLMs) are now deployed worldwide, inspiring a surge of benchmarks that measure their multilingual and multicultural abilities. However, these benchmarks prioritize generic language understanding or superficial…