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Recent progress in multimodal large language models (MLLMs) has demonstrated promising performance on medical benchmarks and in preliminary trials as clinical assistants. Yet, our pilot audit of diagnostic cases uncovers a critical failure…

Artificial Intelligence · Computer Science 2025-09-30 Hongjun Liu , Yinghao Zhu , Yuhui Wang , Yitao Long , Zeyu Lai , Lequan Yu , Chen Zhao

Large Language Models (LLMs) suffer from hallucinations and factual inaccuracies, especially in complex reasoning and fact verification tasks. Multi-Agent Debate (MAD) systems aim to improve answer accuracy by enabling multiple LLM agents…

Computation and Language · Computer Science 2026-01-09 Seyeon Jeong , Yeonjun Choi , JongWook Kim , Beakcheol Jang

Clinical diagnosis is a complex reasoning process in which clinicians gather evidence, form hypotheses, and test them against alternative explanations. In medical training, this reasoning is explicitly developed through counterfactual…

Computation and Language · Computer Science 2026-04-24 Zhiwen You , Xi Chen , Aniket Vashishtha , Simo Du , Gabriel Erion-Barner , Hongyuan Mei , Hao Peng , Yue Guo

The integration of deep learning-based glaucoma detection with large language models (LLMs) presents an automated strategy to mitigate ophthalmologist shortages and improve clinical reporting efficiency. However, applying general LLMs to…

Multiagent Systems · Computer Science 2025-12-18 Philip R. Liu , Sparsh Bansal , Jimmy Dinh , Aditya Pawar , Ramani Satishkumar , Shail Desai , Neeraj Gupta , Xin Wang , Shu Hu

Answering complex medical questions requires not only domain expertise and patient-specific information, but also structured and multi-perspective reasoning. Existing multi-agent approaches often rely on fixed roles or shallow interaction…

Artificial Intelligence · Computer Science 2026-03-04 Siqi Ma , Jiajie Huang , Fan Zhang , Yue Shen , Jinlin Wu , Guohui Fan , Zhu Zhang , Zelin Zang

The advent of large language models (LLMs) has facilitated the development of natural language text generation. It also poses unprecedented challenges, with content hallucination emerging as a significant concern. Existing solutions often…

Computation and Language · Computer Science 2024-06-06 Xiaoxi Sun , Jinpeng Li , Yan Zhong , Dongyan Zhao , Rui Yan

Background: Cognitive biases in clinical decision-making significantly contribute to errors in diagnosis and suboptimal patient outcomes. Addressing these biases presents a formidable challenge in the medical field. Objective: This study…

Computation and Language · Computer Science 2024-05-14 Yu He Ke , Rui Yang , Sui An Lie , Taylor Xin Yi Lim , Hairil Rizal Abdullah , Daniel Shu Wei Ting , Nan Liu

Hallucination continues to pose a major obstacle in the reasoning capabilities of large language models (LLMs). Although the Multi-Agent Debate (MAD) paradigm offers a promising solution by promoting consensus among multiple agents to…

Artificial Intelligence · Computer Science 2025-11-17 Dayong Liang , Xiao-Yong Wei , Changmeng Zheng

MLLMs often generate outputs that are inconsistent with the visual content, a challenge known as hallucination. Previous methods focus on determining whether a generated output is hallucinated, without identifying which image region leads…

Computer Vision and Pattern Recognition · Computer Science 2024-07-31 Zheng Lin , Zhenxing Niu , Zhibin Wang , Yinghui Xu

Multimodal large language models (MLLMs) that integrate visual and textual reasoning leverage chain-of-thought (CoT) prompting to tackle complex visual tasks, yet continue to exhibit visual hallucinations and an over-reliance on textual…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Jing Bi , Guangyu Sun , Ali Vosoughi , Chen Chen , Chenliang Xu

Large Language Models (LLMs) excel in various natural language processing tasks but struggle with hallucination issues. Existing solutions have considered utilizing LLMs' inherent reasoning abilities to alleviate hallucination, such as…

Computation and Language · Computer Science 2025-01-16 Yi Fang , Moxin Li , Wenjie Wang , Hui Lin , Fuli Feng

There are two main barriers to using large language models (LLMs) in clinical reasoning. Firstly, while LLMs exhibit significant promise in Natural Language Processing (NLP) tasks, their performance in complex reasoning and planning falls…

Artificial Intelligence · Computer Science 2024-12-31 Shengxin Hong , Liang Xiao , Xin Zhang , Jianxia Chen

Recent advancements in multimodal large language models (MLLMs) have shown unprecedented capabilities in advancing various vision-language tasks. However, MLLMs face significant challenges with hallucinations, and misleading outputs that do…

Computer Vision and Pattern Recognition · Computer Science 2024-12-24 Shengqiong Wu , Hao Fei , Liangming Pan , William Yang Wang , Shuicheng Yan , Tat-Seng Chua

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings…

Computation and Language · Computer Science 2026-05-28 Zhuohan Ge , Haoyang Li , Yubo Wang , Nicole Hu , Chen Jason Zhang , Qing Li

Large Language Models (LLMs) still face challenges when dealing with complex reasoning tasks, often resulting in hallucinations, which limit the practical application of LLMs. To alleviate this issue, this paper proposes a new method that…

Artificial Intelligence · Computer Science 2024-11-26 Zhihua Duan , Jialin Wang

Medical Large Language Models (MLLMs) play a crucial role in ophthalmic diagnosis, holding significant potential to address vision-threatening diseases. However, their accuracy is constrained by hallucinations stemming from limited…

Computation and Language · Computer Science 2025-10-02 Xiaoyu Pan , Yang Bai , Ke Zou , Yang Zhou , Jun Zhou , Huazhu Fu , Yih-Chung Tham , Yong Liu

Dermatological diagnosis requires integrating fine-grained visual perception with expert clinical knowledge. Although Multimodal Large Language Models (MLLMs) facilitate interactive medical image analysis, their application in dermatology…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Yize Liu , Siyuan Yan , Ming Hu , Lie Ju , Xieji Li , Feilong Tang , Wei Feng , Zongyuan Ge

Multimodal large language models (MLLMs) excel at generating highly detailed captions but often produce hallucinations. Our analysis reveals that existing hallucination detection methods struggle with detailed captions. We attribute this to…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Saehyung Lee , Seunghyun Yoon , Trung Bui , Jing Shi , Sungroh Yoon

While multimodal large language models (MLLMs) have achieved rapid progress in vision-language understanding, they remain prone to multimodal hallucinations, producing responses that are inconsistent with the visual input. Existing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-29 Shizhe Zhou , Bohan Jia , Kai Wu , Yan Shen , Tongyun Li , Yuyang Wu , Shaohui Lin

Large Language Models (LLMs) have demonstrated advanced capabilities but often suffer from factual inaccuracies (hallucinations) and systematic biases. These issues, sometimes amplified in specific architectures like Mixture-of-Experts…

Computation and Language · Computer Science 2026-04-28 Shuai Wu , Xue Li , Yanna Feng , Yufang Li , Zhijun Wang , Ran Wang
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