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We reframe clinician overrides of clinical AI recommendations as implicit preference data - the same signal structure exploited by reinforcement learning from human feedback (RLHF), but richer: the annotator is a domain expert, the…

Machine Learning · Computer Science 2026-05-19 Prabhjot Singh , Abhishek Gupta , Chris Betz , Abe Flansburg , Brett Ives , Sudeep Lama , Jung Hoon Son

The current reward learning from human preferences could be used to resolve complex reinforcement learning (RL) tasks without access to a reward function by defining a single fixed preference between pairs of trajectory segments. However,…

Artificial Intelligence · Computer Science 2020-12-29 Zehong Cao , KaiChiu Wong , Chin-Teng Lin

Dynamic Treatment Regimes (DTRs) provide a systematic approach for making sequential treatment decisions that adapt to individual patient characteristics, particularly in clinical contexts where survival outcomes are of interest.…

Machine Learning · Computer Science 2025-03-11 Animesh Kumar Paul , Russell Greiner

Process-supervised reward models (PRMs) excel at providing step-by-step verification for large language model (LLM) outputs in domains like mathematics and coding. However, their application to fields lacking ground-truth answers, such as…

Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited. This is likely due to their insufficient exposure to…

Sepsis is a leading cause of death in the ICU. It is a disease requiring complex interventions in a short period of time, but its optimal treatment strategy remains uncertain. Evidence suggests that the practices of currently used treatment…

Machine Learning · Computer Science 2022-07-15 Zeyu Wang , Huiying Zhao , Peng Ren , Yuxi Zhou , Ming Sheng

Traditional recommendation systems estimate user preference on items from past interaction history, thus suffering from the limitations of obtaining fine-grained and dynamic user preference. Conversational recommendation system (CRS) brings…

Information Retrieval · Computer Science 2020-07-02 Wenqiang Lei , Gangyi Zhang , Xiangnan He , Yisong Miao , Xiang Wang , Liang Chen , Tat-Seng Chua

Existing studies on reinforcement learning (RL) for sepsis management have mostly followed an established problem setup, in which patient data are aggregated into 4-hour time steps. Although concerns have been raised regarding the…

Machine Learning · Computer Science 2025-11-27 Yingchuan Sun , Shengpu Tang

Guideline-based treatment for sepsis and septic shock is difficult because sepsis is a disparate range of life-threatening organ dysfunctions whose pathophysiology is not fully understood. Early intervention in sepsis is crucial for patient…

Machine Learning · Computer Science 2021-09-24 Ran Liu , Joseph L. Greenstein , James C. Fackler , Jules Bergmann , Melania M. Bembea , Raimond L. Winslow

Reinforcement Learning (RL) has recently been applied to sequential estimation and prediction problems identifying and developing hypothetical treatment strategies for septic patients, with a particular focus on offline learning with…

Machine Learning · Computer Science 2020-11-24 Taylor W. Killian , Haoran Zhang , Jayakumar Subramanian , Mehdi Fatemi , Marzyeh Ghassemi

Sepsis is a syndrome that develops in the body in response to the presence of an infection. Characterized by severe organ dysfunction, sepsis is one of the leading causes of mortality in Intensive Care Units (ICUs) worldwide. These…

Machine Learning · Computer Science 2023-11-20 Tucker Stewart , Katherine Stern , Grant O'Keefe , Ankur Teredesai , Juhua Hu

Sepsis, a life-threatening inflammatory response to infection, causes organ dysfunction, making early detection and optimal management critical. Previous reinforcement learning (RL) approaches to sepsis management rely primarily on…

Machine Learning · Computer Science 2025-08-12 Yooseok Lim , ByoungJun Jeon , Seong-A Park , Jisoo Lee , Sae Won Choi , Chang Wook Jeong , Ho-Geol Ryu , Hongyeol Lee , Hyun-Lim Yang

Standard reinforcement learning (RL) aims to find an optimal policy that identifies the best action for each state. However, in healthcare settings, many actions may be near-equivalent with respect to the reward (e.g., survival). We…

Machine Learning · Computer Science 2020-07-27 Shengpu Tang , Aditya Modi , Michael W. Sjoding , Jenna Wiens

In session-based or sequential recommendation, it is important to consider a number of factors like long-term user engagement, multiple types of user-item interactions such as clicks, purchases etc. The current state-of-the-art supervised…

Machine Learning · Computer Science 2020-06-12 Xin Xin , Alexandros Karatzoglou , Ioannis Arapakis , Joemon M. Jose

Foundation models in healthcare have largely adopted self supervised pretraining objectives inherited from natural language processing and computer vision, emphasizing reconstruction and large scale representation learning prior to…

Machine Learning · Computer Science 2026-03-24 Yang Zhang , Li Fan , Samuel Lawrence , Shi Li

Personalized alignment is crucial for enabling Large Language Models (LLMs) to engage effectively in user-centric interactions. However, current methods face a dual challenge: they fail to infer users' deep implicit preferences (including…

Artificial Intelligence · Computer Science 2026-04-29 Peiming Li , Zhiyuan Hu , Yang Tang , Shiyu Li , Xi Chen

As a subfield of machine learning, reinforcement learning (RL) aims at empowering one's capabilities in behavioural decision making by using interaction experience with the world and an evaluative feedback. Unlike traditional supervised…

Machine Learning · Computer Science 2020-04-27 Chao Yu , Jiming Liu , Shamim Nemati

Recent advances in medical large language models have explored Test-Time Reinforcement Learning (TTRL) to enhance reasoning. However, standard TTRL often relies on majority voting (MV) as a heuristic supervision signal, which can be…

Machine Learning · Computer Science 2026-03-11 Kailong Fan , Anqi Pu , Yichen Wu , Wanhua Li , Yicong Li , Hanspeter Pfister , Huafeng Liu , Xiang Li , Quanzheng Li , Ning Guo

Preference-based reinforcement learning (PbRL) aligns a robot behavior with human preferences via a reward function learned from binary feedback over agent behaviors. We show that dynamics-aware reward functions improve the sample…

Artificial Intelligence · Computer Science 2024-02-29 Katherine Metcalf , Miguel Sarabia , Natalie Mackraz , Barry-John Theobald

Reinforcement Learning (RL) is a computational approach to reward-driven learning in sequential decision problems. It implements the discovery of optimal actions by learning from an agent interacting with an environment rather than from…

Methodology · Statistics 2022-10-06 Mauricio Tec , Yunshan Duan , Peter Müller